Drug target
The influence of drug distribution and drug-target binding on target occupancy: The rate-limiting step approximation
... the target vicinity and the bulk solution (Goldstein and Dembo, 1995; Coombs and Goldstein, ...of target binding that could not be explained by drug-target binding from bulk/tissue ...
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Predicting the Reliability of Drug-target Interaction Predictions with Maximum Coverage of Target Space
... false-positive target predictions are for five query drugs: Solifenacin, Citalopram, Escitalopram, Neostigmine and ...predicted target, whereas the hits are annotated with the murine homologue of that ...
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Drug-Target Interaction Networks Prediction Using Short-linear Motifs
... predict drug-target interaction which firstly introduces short-linear motifs (SLiMs) as protein features into this ...Concerning drug features, we select two kinds of chemical substructure ...
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Similarity based learning method for drug target interaction prediction
... known drug compounds systematically is considered as obsolete, superfluous amount of human genome data available publicly altered the industry’s internal working ...screening drug data to identify ...
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Leptin signaling molecular actions and drug target in hepatocellular carcinoma
... Abstract: Previous reports indicate that over 13 different tumors, including hepatocellular carcinoma (HCC), are related to obesity. Obesity-associated inflammatory, metabolic, and endo- crine mediators, as well as the ...
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ROLE OF BIOINFORMATICS, CHEMOINFORMATICS AND PROTEOMIC IN BIOMARKER IDENTIFICATION AND DRUG TARGET VALIDATION IN DRUG DISCOVERY PROCESSES
... and drug target validation are highly complex and resource-intensive processes, requiring an integral use of various tools, approaches and ...of target candidates and correlating this information to ...
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Supervised prediction of drug target interactions by ensemble learning
... In general, the classification-based models may benefit from the sophisticated binary classification algorithms. However, there are much more non-interaction drug-target pairs than interaction pairs. In ...
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Drug target ontology to classify and integrate drug discovery data
... sures drug binding using a panel of ~440 recombinant purified kinases, namely, KINOMEscan ...the drug-target ...curated target metadata table were analyzed by ontologists to create kinase ...
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The Response Regulator BfmR Is a Potential Drug Target for Acinetobacter baumannii
... of drug and drug-like virtual ...elaborate drug-like small molecules was further evaluated through a blind docking ...binding drug-like molecules ...
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Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target
... potential target for development of new drugs that alter spindle function ...interfering drug paclitaxel or vinblastine induces more cytoskeleton defects in HeLa cells depleted of MCAK ...good target ...
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FOXM1: A novel drug target in gastroenteropancreatic neuroendocrine tumors
... Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are heterogeneous tumors that need to be molecularly defined to obtain novel therapeutic options. Forkheadbox protein M1 (FOXM1) is a crucial transcription ...
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Cyclin dependent kinase 12, a novel drug target for visceral leishmaniasis
... Extended Data Table 6: Sensitivity of WT and compound 5-resistant intramacrophage amastigotes INMAC to the compound series... Host cell pXC50..[r] ...
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Hedgehog pathway as a drug target: Smoothened inhibitors in development
... Abstract: Emerging laboratory and clinical investigations demonstrate that Hedgehog signaling (Hh) represents a novel therapeutic target in various human cancers. This conserved signaling pathway precisely ...
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RAS GTPase AS THE DRUG TARGET FOR ANTI CANCER DESIGNING OF DRUG FROM TEMPLATE
... RESULTS AND DISCUSSIONS: Eight ras GTPase complexes, 1K8R, 2KE5, 2UZI, 2VH5, 4GZL, 4GZM, 3GFT and 3TSO have been identified from the repository. By sequence analysis, the properties such as instability index, aliphatic ...
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DASPfind: new efficient method to predict drug–target interactions
... current drug targets [9, ...a target protein [11, ...a drug two-dimensional (2D) structural similarity is pre- sented in [11], and is known as the similarity ensemble approach ...lar target ...
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IRAK 4: a new drug target in inflammation, sepsis and autoimmunity
... Another intriguing possibility arises from the amino acid sequence of sigma receptors (7). The sigma-1 receptor, which is the isoform used in the studies of potassium channel regulation described above, shares some ...
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Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba
... many drugs do not work so well against cysts or even induce Acanthamoeba to encyst. GAE is almost always fatal despite extreme measures including multiple drug combinations combined with surgical procedures or ...
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Notch signaling in glioblastoma: a developmental drug target?
... GBM is the most prevalent and the most aggressive brain tumor against which conventional therapies, that is, radiotherapy, chemotherapy and surgery have led until now to only transient clinical response followed by tumor ...
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The trypanosome alternative oxidase : a potential drug target?
... Expression of the Alternative Oxidase in the Procyclic Forms of Trypanosoma.. World Health Organization.[r] ...
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Fibromyalgia pathogenesis provides drug target clues
... 16. Field MJ, Cox PJ, Stott E, Melrose H, Offord J, Su TZ, Bramwell S, Corradini L, England S, Winks J, Kinloch RA, Hendrich J, Dolphin AC, Webb T & Williams D. Identification of the alpha2-delta-1 subunit of ...
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