DSS-induced colitis
TREM-1-dependent M1 macrophage polarization restores intestinal epithelium damaged by DSS-induced colitis by activating IL-22-producing innate lymphoid cells
... of DSS-induced colitis, we injected recom- binant IL-22 into the peritoneal cavities of TREM-1- deficient mice every other day, starting 1 day prior to DSS ...in DSS-treated TREM-1 KO ...
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Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice
... receptor (TCR). This reaction damages the conformational flexibility of TCR complex, and inhibits its binding with peptide-loaded MHC and leads to the unresponsiveness of T cells to antigen-specific stimulation [8, 15, ...
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rSj16 Protects against DSS-Induced Colitis by Inhibiting the PPAR-α Signaling Pathway
... be induced by Chil1 and Chil3 [12, ...on DSS-induced colitis in mice were associated with the ability of rSj16 to regulate the production of inflammatory mediators and ...
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KARANJIN AMELIORATE DSS INDUCED COLITIS IN C57BL/6 MICE
... DSS induced colitis histologically shows mucosal and submucosal lymphocyte, macrophages, polymorphonuclear leukocyte, tissue mast cell infiltration, destruction of epithelial architecture with loss ...
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Bifidobacterium infantisstrains with and without a combination of Oligofructose and Inulin (OFI) attenuate inflammation in DSS-induced colitis in rats
... the colitis control group. Colitis was induced by 5% (w/v) DSS (MW = 36,000–50,000; ICN Biomedicals ...of colitis was assessed daily using a disease activ- ity index ...
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Intraluminal Injection of Mesenchymal Stromal Cells in Spheroids Attenuates Experimental Colitis
... with GFP-positive MSCs and injected them intraluminally in mice with DSS-induced colitis, and these MSCs were not found in the mucosa [Supplementary Figure 3]. In addition, for confirmation, we ...
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Article: Dextran sulfate sodium-induced colitis mice up-regulated extracellular matrix tenascin-C
... and DSS-inflamed ...colon. DSS-induced colon showed a huge number of positive cells particularly in the inflamed areas including mucosal and muscular layer (Figure ...in DSS-induced ...
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Mak'Anyengo, Rachel (2017): Role of the NIrp3 inflammasome in regulation of the tolerogenic function of CD103+ dendritic cells in CD4+CD45RbHigh T cell transfer colitis and in steady state. Dissertation, LMU München: Medizinische Fakultät
... (DSS)-induced colitis is an important model for the study of mucosal damage and innate immunity in ...up DSS, leading to activation of the Nlrp3 ...
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Intestinal barrier regulates immune responses in the liver via IL-10–producing macrophages
... of colitis and subsequent liver injury, mice were pre- treated with DSS for 3–7 ...of DSS-induced colitis was correlated with the duration of DSS administration (Figure ...with ...
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Possible Effects of Moringa oleifera versus Ginger (Zingiber officinalis) on Experimental Colitis in Mice
... of colitis in mice by DDS (5%) was obvious with increased DAI (loss of weight, diarrhea and blood in ...between DSS induced colitis group and control ...with DSS induced ...
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Protective effects of Huangqin Decoction against ulcerative colitis and associated cancer in mice
... baicalin induced Foxp3 protein expression in cultured T cells, and stimulated Treg cells to decrease Th17 cells in inflammatory tissues [27, ...in DSS-induced colitis and ...
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An Inhibitor of Casein Kinase 1ε/δ (PF670462) Prevents the Deterioration of Dextran Sodium Sulfate-induced Ulcerative Colitis Caused by UVB Eye Irradiation
... (CK1ε/δ inhibitor: PF670462) was accompanied by increased expression of PER2. The expression of the clock gene did not change with single administrations of CK1ε/δ inhibitor (data not shown). However, the period of the ...
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Oral iron exacerbates colitis and influences the intestinal microbiome
... of colitis induced using dextran sulfate sodium (DSS), on (i) clinical and histological severity of acute DSS-induced colitis, and (ii) faecal microbial diversity, as assessed by ...
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Adiponectin and adiponectin receptor 1 overexpression enhance inflammatory bowel disease
... It is well known that the cox2/PGE2 pathway plays an important role in inflammation. Our data showed that ADN and AdipoR1 enhanced the expression of colonic cox2, like to Arsenescu’s previous report [17]. However, ...
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Fermented herbal formula KIOM MA 128 protects against acute colitis induced by dextran sodium sulfate in mice
... of colitis and the effects of our formula, we examined the histological changes in the large intestine after the administration of DSS with K- ...of DSS-induced damage in colon tissues, and ...
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MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation
... ameliorate colitis remains ...experimental colitis in mice, followed by mechanistic analysis on NF-κB and NLRP3 inflammasome ...of colitis in mice, evidenced by reduction in the elevated disease ...
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The Influence of Genetic Background on Experimentally-Induced Colitis in Murine Models of Inflammatory Bowel Disease.
... of DSS administration or the recovery ...Because DSS is toxic to the epithelial cells lining the intestine, administration of DSS in susceptible strains disrupts this barrier allowing entry of ...
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Invitro and invivo pharmacological studies using chitosan
... As DSS is a large and negatively charged molecule that cannot easily cross the membranes, it is poorly absorbed after oral ...administration. DSS causes a toxic effect on the colon epithelial cells ...
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TSG-6 released from intraperitoneally injected canine adipose tissue-derived mesenchymal stem cells ameliorate inflammatory bowel disease by inducing M2 macrophage switch in mice
... of DSS-induced colitis compared with local anal injection, suggesting that systemic immunomodulation rather than reducing local inflammation is required for effective therapy ...
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Original Article The effects of Qing Hua Chang Yin on the epithelial tight junctions of mice with inflammatory bowel disease
... ulcerative colitis mouse model. Colitis was induced by the administration of ...of DSS-induced colitis was monitored daily in a blinded manner, including the observation of ...
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