Dual Role
Dual role of the integrated stress response in medulloblastoma tumorigenesis
... models [27]. Importantly, our previous study showed that PERK haploinsufficiency reduces the incidence of medulloblastoma in Ptch1+/− mice. Intriguingly, PERK haploinsufficiency enhances apoptosis of pre-malignant GCPs ...
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A dual role typology of multinational subsidiaries
... Since different types of multinational subsidiaries can play different roles in improving efficiency at both the subsidiary and corporate level, as well as in enhancing local capability development in the host-country ...
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Forensic psychology, the dual role issue and informed consent
... In spite of any checklists, forms or interventions that can be developed, perhaps the root of the problem is the way the Criminal Justice System views forensic psychologists. It would appear that the dual ...
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MicroRNA-375 plays a dual role in prostate carcinogenesis
... a dual role in PCa, acting either as an oncomiR or a tumor- suppressor miRNA, depending on the cellular ...that dual role in the same tumor model, depending on the stage of tumor progression ...
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The dual role of Escherichia coli in the course of ulcerative colitis
... Background: This study examines the dual role of Escherichia coli in the course of ulcerative colitis (UC). The intestinal microbiota is considered to play an important role in UC pathogenesis, but ...
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A servant of two masters: The dual role of the budget in nonprofits
... managerial role. A properly designed budget should have a dual role: it should provide the organization's management with tools for decision making and at the same time should serve as a fund raising ...
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Title: Loss of total phenol in two shrub leaf litter species: the dual role of alpine forest gap disturbance
... Furthermore, our data also showed the dual role of forest gap disturbance on the abundances of fungi and bacteria across the gap location properties well (Fig. 3). During the winter, abundant fungi and ...
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The dual role of silver during silicon etching in HF solution
... During metal-assisted etching experiences, some researchers reported that silver protects silicon. How- ever, others confirmed that silver catalyzes the silicon underneath. In this paper, we give experimental results ...
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The dual role of asporin in breast cancer progression
... Asporin has been reported as a tumor suppressor in breast cancer, while asporin- activated invasion has been described in gastric cancer. According to our in silico search, high asporin expresion associates with ...
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Dual role of nNOS in ischemic injury and preconditioning
... a dual role so that its presence is necessary to afford cardioprotection by IP, but at the same time its inhibi- tion reduces myocardial ischemic/reoxygenation induced ...
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Dual role of nanoparticles as drug carrier and drug
... Abstract The conventional chemotherapeutic agents used in the treatment of human malignancies are directed nonspecifically against both malignant and nonmalignant cells, often limiting their efficacy with having serious ...
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Once a clinician, always a clinician: a systematic review to develop a typology of clinician-researcher dual-role experiences in health research with patient-participants
... of dual-role occur dur- ing data collection, and some are ...which dual-role shows up, whenever it ...of dual-role [2, 46] and cannot predict the ...a dual role ...
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The dual role of tetraspanin CD63 in HIV 1 replication
... the role of CD63 in late stage HIV-1 replication, CD63 siRNA was transfected into U1/HIV-1 cells, which are chronically infected monocytoid cells harboring 2 integrated copies of provirus per cell ...a role ...
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Dual Role of a Viral Polymerase in Viral Genome Replication and Particle Self Assembly
... potential role of ⌽ 6 RdRp in PC formation in the self-assembly system and analyzed the replication and transcription activities of the self-assembled ...the role of the specific P1-P2 ...a role not ...
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Dual role of autophagy in HIV-1 replication and pathogenesis
... The clearance of misfolded and aggregate proteins via autophagy plays a protective role against neurodegenera- tive disorders such as Huntington ’ s and Parkinson ’ s dis- ease [97,98]. Defects in this ...
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Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii
... a role for caspase-1 and IL-18 in murine ...pivotal role in mediating acute toxoplas- mosis, with the cytokine playing an important early role in the control of parasite replication ...
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Collagen VII plays a dual role in wound healing
... Although a host of intracellular signals is known to contribute to wound healing, the role of the cell microen- vironment in tissue repair remains elusive. Here we employed 2 different mouse models of genetic skin ...
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Undergraduate Honors Theses Theses, Dissertations, Capstones and Projects 1985 The dual role of cadmium on leucine transport in human erythrocytes
... carcinogen in animals (Furst and Schlauder, 1977; Rivedal and Sanner, 1981; Rubin and Kroll, 1981; Takenaka et al., 1983), and a potential carcinogen causing lung and renal cancer in humans (Potts, 1965; Kolonel, 1976). ...
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A dual role for ErbB2 signaling in cardiac trabeculation
... Prior studies have shown that mouse embryos deficient in Neuregulin 1 (Nrg1), ErbB2 or ErbB4 do not develop cardiac trabeculation and consequently die at mid-gestation (Gassmann et al., 1995; Lee et al., 1995; Meyer and ...
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Dual role of Miro protein clusters in mitochondrial cristae organisation and ER Mitochondria Contact Sites
... To further explore the effects of depleting Miro proteins on mitochondrial structure and morphology, we carried out ultra- structural analysis of MEF cells using transmission electron microscopy (TEM). In WT MEFs, the ...
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