E2 ubiquitin-conjugating enzyme
Functional Characterization of Residues Required for the Herpes Simplex Virus 1 E3 Ubiquitin Ligase ICP0 To Interact with the Cellular E2 Ubiquitin-Conjugating Enzyme UBE2D1 (UbcH5a)
... E3 ubiquitin ligases counteract multiple aspects of antiviral immunity using a variety of ...specific E2 ubiquitin-conjugating enzymes to induce both monoubiquitination and K63-linked ...
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The Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein Requires the Ubiquitin-Conjugating Enzyme Ubc13 for NF-κB Activation
... Ubiquitination of the human T-cell leukemia virus 1 Tax oncoprotein provides an important regulatory mechanism that promotes the Tax-mediated activation of NF- B. However, the type of polyubiquitin chain linkages and ...
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Cdc34p Ubiquitin-Conjugating Enzyme Is a Component of the Tombusvirus Replicase Complex and Ubiquitinates p33 Replication Protein
... chaperones, ubiquitin-associated proteins, translation factors, RNA-modifying enzymes, and other proteins with yet-unknown ...Cdc34p E2 ubiquitin-conjugating enzyme, which is one of the ...
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RING-H2 Protein WSSV249 from White Spot Syndrome Virus Sequesters a Shrimp Ubiquitin-Conjugating Enzyme, PvUbc, for Viral Pathogenesis
... low E2 specificity in the ubiquitination ...cancer-related E2 ubiquitin-conjugating ...Both E2 enzymes play key roles in human-related dis- eases, which is of significance to our WSSV ...
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Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3
... of E2 ubiquitin–conjugating enzymes for their ability to cooperate with MuRF1 and MuRF3 to ubiquitinate β/slow MHC and MHCIIa and found that MuRF1 and MuRF3 use the E2 ...
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Effete, a Drosophila Chromatin-Associated Ubiquitin-Conjugating Enzyme That Affects Telomeric and Heterochromatic Position Effect Variegation
... an E2 ubiquitin-conjugating enzyme (see Intro- duction), some of the Eff targets might not be properly mono- or polyubiquitinated, leading to defects in chromatin ...
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Ubiquitin conjugating enzyme involved in the immune response caused by pathogens invasion
... of E2 variant protein, has been shown special interaction with the p6 region of HIV-1 Gag protein in mammalian ...mori E2, involved in antivirus against nucleopolyhedrovirus, has been found by fluo- rescent ...
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Effect of prolonged intravenous glucose and essential amino acid infusion on nitrogen balance, muscle protein degradation and ubiquitin-conjugating enzyme gene expression in calves
... We therefore conducted an in vivo study to examine the hypothesis that co-infusion of glucose and EAA would act synergistically to improve nitrogen balance by decreasing muscle protein degradation in association with ...
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Functional Interaction between Human Herpesvirus 6 Immediate-Early 2 Protein and Ubiquitin-Conjugating Enzyme 9 in the Absence of Sumoylation
... small ubiquitin-related modifier (SUMO) moiety to a target ...a conjugating E2 en- zyme (Ubc9) (14, 22, 36, 68), and one of the many SUMO-1 E3 ligases, such as PIASy or RanBP2 (58, ...of ...
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Modification of Nonstructural Protein 1 of Influenza A Virus by SUMO1
... (small ubiquitin-like modifier) pro- teins was recently discovered as a group of reversible post- translational protein ...with ubiquitin and are covalently attached to target proteins in a similar fashion ...
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The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis
... large-size E2, UBE2O has been reported to modify several important proteins in an atypical ubiquitination manner, such as K63-polyubiquitination [5] and monoubiquitina- tion ...
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The KCTD family of proteins: structure, function, disease relevance
... successful ubiquitination of substrate proteins [26]. Cul3 is one of seven human cullin proteins (Cul1,Cul2,Cul3, Cul4A,Cul4B,Cul5, and Cul7). Most cullins form com- plexes with substrate proteins by interacting with the ...
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lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2
... and E2-C type E2s bind in vitro either to the Apc2 or Apc11 subunit of the cata- lytic subcomplex ...of E2 mutants in yeast and Drosophila suggests that, in vivo, the E2-C type enzymes are required ...
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Ubiquitin control of S phase: a new role for the ubiquitin conjugating enzyme, UbcH7
... Two E2 ligases have been described which are respon- sible for targeting for degradation a number of crucial cell cycle regulatory ...primary E2 that cooper- ates with the Anaphase Promoting ...
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SUMO-Conjugating Enzyme E2 UBC9 Mediates Viral Immediate-Early Protein SUMOylation in Crayfish To Facilitate Reproduction of White Spot Syndrome Virus
... SUMOylation participates in multiple biological processes and plays a significant role in transcriptional regulation (9, 14). The most well-known SUMOylation substrate is p53, which is modi- fied by SUMO at the C ...
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Ubiquitin conjugating enzyme UBE2J1 negatively modulates interferon pathway and promotes RNA virus infection
... of ubiquitin lysines. Different E2 enzymes influence distinct types of ubiquitin ...the E2 en- zyme UBE2N (also known as Ubc13) heterodimerizes with UBE2V1, and mediates K63-linked ...
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Analysis of binary interactions between OTUB1 and E2 ubiquitin-conjugating enzymes
... attached ubiquitin from proteins, either from the polyubiquitin chain or from the substrate (Wilkinson, ...all ubiquitin machineries, the functions, targets and regulation of DUBs are the most poorly ...
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Structure-Function Analysis of Yeast mRNA Cap Methyltransferase and High-Copy Suppression of Conditional Mutants by AdoMet Synthase and the Ubiquitin Conjugating Enzyme Cdc34p
... Bai, C., P. Sen, K. Hofmann, L. Ma, M. Goebl et al., 1996 SKP1 Hu, G., P. D. Gershon, A. E. Hodel and F. A. Quiocho, 1999 mRNA connects cell cycle regulators to the ubiquitin proteolysis machin- cap recognition: ...
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Gene expression in HCV-associated HCC-identification of an up-regulated gene encoding a protein related to ubiquitin conjugating enzyme
... expressed at higher levels in the human malignant cell lines group as compared to the. normal adult and foetal tissues (Figure 4.11)[r] ...
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Microarray-based analysis and clinical validation identify ubiquitin-conjugating enzyme E2E1 (UBE2E1) as a prognostic factor in acute myeloid leukemia
... Results: Microarray-based analysis suggested that expression of eight genes was each associated with 1-year and 3-year AML OS in both GSE12417 and GSE8970 datasets ( p < 0.05). Next, we validated our findings in an ...
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