EAE/MS
Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS
... ence MS susceptibility ...and MS severity was limited to women [9]; however, this has not been described in other studies ...of EAE as well as MS by taking into consideration potential ...
7
Expression of IL-1β in rhesus EAE and MS lesions is mainly induced in the CNS itself
... for MS, has been con- firmed in different studies ...of EAE in both rats and mice [22–25], and mice that are deficient in NLRP3, ASC, or caspase 1 expression are characterized by delayed onset of disease ...
16
Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis
... in MS and EAE [4] is related to two main ...in MS patients [12], and appears in the periven- tricular normal-appearing white matter of MS patients using dynamic contrast-enhanced MRI imaging ...
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Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model
... in EAE, in the animal model of MS [15, 30–34], and in EAE-ON [35] using histo- logical quantification of axons in the optic ...in EAE-ON using in vivo ...in EAE-ON translates to in vivo ...
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Involvement of β-chemokines in the development of inflammatory demyelination
... on EAE and MS suggest that CC chemokine lig- ands (most prominently CCL2, CCL3, CCL5, CCL7, CCL8, but also CCL1, CCL4, CCL19 and CCL21) expressed by residential immune cells in the CNS or by endothelial ...
14
Endogenously regulated Dab2 worsens inflammatory injury in experimental autoimmune encephalomyelitis
... MOG35-55 EAE model is a model of axonal injury and inflammation, with little de- myelination or oligodendrocyte death ...to EAE. Secondly, dab2 -defi- cient EAE mice exhibited smaller inflammatory ...
14
Silencing of Abcc8 or inhibition of newly upregulated Sur1-Trpm4 reduce inflammation and disease progression in experimental autoimmune encephalomyelitis
... 2]. MS has no known cure, and patients suffer from progressive disability due to irreversible neurological ...damage. MS and its principal animal model, experimental autoimmune encephalomyelitis ...
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Treatment of the bone marrow stromal stem cell supernatant by nasal administration—a new approach to EAE therapy
... the EAE model of rMOG immunization, the B cell-mediated EAE ...for MS confirmed in recent years, B lymphocytes from the spleen at peak phase of rMOG-immunized EAE model were cultured in vitro, ...
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Endogenous Erythropoietin as Part of the Cytokine Network in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
... Erythropoietin (EPO) is of great interest as a therapy for many of the central nervous system (CNS) diseases and its adminis- tration is protective in experimental autoimmune encephalomyelitis (EAE), an animal ...
7
Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant
... to EAE mice, no EO6 immunostaining (section C) or immune infiltrates (not shown) could be observed in naïve ...untreated, EAE and naïve mice (section ...with MS, 6 in the Nano-PSO-treated EAE ...
10
Amlexanox attenuates experimental autoimmune encephalomyelitis by inhibiting dendritic cell maturation and reprogramming effector and regulatory T cell responses
... In MS patients, TBK1 expression is upregulated in peripheral blood mono- nuclear cells (PBMCs), indicating its vital role in the occurrence and development of MS [27, ...
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Effects of Bu Shen Yi Sui Capsule on Th17/Treg cytokines in C57BL/6 mice with experimental autoimmune encephalomyelitis
... medicine); MS: Multiple sclerosis; EAE: Experimental autoimmune encephalomyelitis; TGF: Transforming growth factor; ROR: Retinoic acid-related orphan receptor; FoxP3: Forkhead box P3; PA: Prednisone ...
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Effect of catalpol on remyelination through experimental autoimmune encephalomyelitis acting to promote Olig1 and Olig2 expressions in mice
... of MS, although the corticosteroid hormone and interferon beta are widely used in the acute and remission stage [18, ...of MS, with few side-effects [21, ...in EAE have not been extensively ...
15
Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis
... of MS are asso- ciated with changes in cell viability and clinical disease, through processes relevant to pathogenesis in a model of ...of EAE compared to baseline and are lowest at times of peak ...of ...
17
Elevated axonal membrane permeability and its correlation with motor deficits in an animal model of multiple sclerosis
... in EAE mice [5, 12, 15, 17, 54, 56, ...in MS. To further stress the im- portance of axonal degeneration in MS, there is evidence that axonal damage and neurodegeneration may be the main cause of ...
8
Pain in experimental autoimmune encephalitis: a comparative study between different mouse models
... in EAE include regulated glial factors such as those that comprise the chemokine monocyte chemo- attractant protein-1 (MCP-1), which is released from glia cells and can attract various cell types involved in in- ...
15
Endogenous adaptation to low oxygen modulates T-cell regulatory pathways in EAE
... study, we found that pimonidazole staining was restricted to splenocytes and leukocytes infiltrating the spinal cord in MOG-immunized EAE mice. We further show that en- dogenous adaptation to chronic mild hypoxia ...
14
Antibodies to the RNA-binding protein hnRNP A1 contribute to neurodegeneration in a model of central nervous system autoimmune inflammatory disease
... and requires further study, and (3) immune markers in this model have not yet been examined. Recent data sug- gest that dying back axonopathy and Wallerian degener- ation might involve a common pathogenic mechanism. This ...
12
The tale of histone modifications and its role in multiple sclerosis
... ameliorate EAE through sup- pression of inflammatory cells infiltration in the spinal cord ...of EAE in mice ...treating MS with these inhibitors is the lack of specificity, which would cause a ...
12
Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis
... including EAE [14,15,17-19,22]. GFAP-IκBα-dn mice exposed to MOG-induced EAE exhibited a significant functional recovery compared to WT mice and this dir- ectly correlated with the suppression of ...
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