Early Endosomes
Retrograde Transport from Early Endosomes to the trans-Golgi Network Enables Membrane Wrapping and Egress of Vaccinia Virus Virions
... as early and late endosomes even when COPII-mediated cargo transport from the ER is inhibited, indicating that the anterograde pathway is not utilized ...from early endosomes through the ...
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Integration of GPCR signaling and sorting from very early endosomes via opposing APPL1 mechanisms
... Endocytic trafficking is a critical mechanism for cells to decode complex signaling pathways, including those activated by G-protein-coupled receptors (GPCRs). Heterogeneity in the endosomal network enables GPCR activity ...
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Calcium-Dependent Rubella Virus Fusion Occurs in Early Endosomes
... the relevant concentration for RuV fusion is presumably at the endosome membrane. On the other hand, our finding of calcium- triggered membrane insertion of RuV E1 at neutral pH suggested that the relevant ...
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Orthobunyavirus Entry into Neurons and Other Mammalian Cells Occurs via Clathrin-Mediated Endocytosis and Requires Trafficking into Early Endosomes
... to early endosomes, is required for LACV ...through early endosomes for infection, but un- like LACV, membrane fusion occurs in late endosomal compart- ments, probably because of the lower pH ...
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Mouse Polyomavirus Enters Early Endosomes, Requires Their Acidic pH for Productive Infection, and Meets Transferrin Cargo in Rab11-Positive Endosomes
... classical endocytic pathway via clathrin-coated pits to enter early endosomes (30), while SV40 is internalized by caveolae (1). Also, another human polyomavirus, BK virus, is dependent on an intact ...
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Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
... in early endosomes was deduced from confocal microscopic analysis showing colocalization with RITC-Tf but not with CI-MPR or ...in early endosomes and recycled to the cell surface, without ...
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Neurospora crassa NKIN2, a Kinesin-3 Motor, Transports Early Endosomes and Is Required for Polarized Growth
... YPT52 was N-terminally tagged with GFP and expressed from the ccg-1 promoter. YPT52 localized to bidirectionally moving spots in germlings and young hyphae (Fig. 3A and B; see Movie S3 in the supplemental material). In ...
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Role of TSPAN9 in Alphavirus Entry and Early Endosomes
... SFV-containing early endosomes ...affect early endosome pH or cel- lular cholesterol ...that endosomes in TSPAN9-depleted cells become acidified, as de- tected by LysoTracker staining and ...
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Hepatitis C Virus Entry Requires a Critical Postinternalization Step and Delivery to Early Endosomes via Clathrin-Coated Vesicles
... mediated membrane fusion. We cannot completely exclude the possibility that conformational changes and protein dissocia- tion kinetics leading up to fusion are exceptionally slow for HCV E1E2 and require the continuous ...
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Early endosomes and endosomal coatomer are required for autophagy
... of early endosomes with AVs, and suggest that the EEA1-positive endosomes are involved in AV ...that early endosomes can fuse with AVis (Gordon and Seglen, 1988; Tooze et ...
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Why are Functional Amyloids Non-Toxic in Humans?
... Sequestering Functional Amyloid Assembly Reactions within Membrane Bound Compartments PMEL assembles into fibrils within early endosomes and melanosomes, whereas amyloid fibrils formed b[r] ...
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Dynamics of Chikungunya Virus Cell Entry Unraveled by Single-Virus Tracking in Living Cells
... (20). Previous stud- ies on alphaviruses showed that SFV fused from within early en- dosomes, and VEEV was found to fuse from maturing and/or late endosomes (18, 21, 61, 62). Our single-particle tracking ...
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Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23
... Avl-positive early endosomes while some has passed into Rab7-positive late endosomes (Figure ...after early endosomes matured and were incorporated into late ...
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Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking
... from early endosomes to multivesicular bodies (MVBs) and finally the vacuole (Mullins and Bonifacino, ...from early endosomes until they are segregated from the cytoplasm inside ...from ...
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Amyloid precursor protein–mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration
... in endosomes in fibroblasts further support that APP is linked to endosomal dys- function (19, 26, 28, 29, ...of early endosomes; (b) Which physiological events are impacted, and of these, which ...
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Virus Control of Trafficking from Sorting Endosomes
... Ubiquitin-specific protease 6 restores trafficking of some CIE cargos and ARF6 from the SE. While no one specific host factor has been identified as regulating the dissociation of ARF6 membranes from EEA1-positive SEs for ...
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Cathepsin W Is Required for Escape of Influenza A Virus from Late Endosomes
... of early endosomes to late endosomes by fusion with lysosomal vesicles or proton influx and acidification (6, ...of endosomes and fuses at low pH with the endosomal membrane ...
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The NAE Pathway : autobahn to the nucleus for cell surface receptors
... the early endosome ...late endosomes and lysosomes, or (ii) returned to the plasma membrane using fast or slow recycling routes, or (iii) trafficked to the Golgi apparatus ...of early ...
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Pinpointing retrovirus entry sites in cells expressing alternatively spliced receptor isoforms by single virus imaging
... acidic endosomes and virus-endosome ...Rab5-positive endosomes (middle) and after fusion with early endosomes ...+ endosomes, lumen acidification and ...
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Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions
... Recycling endosomes maintain plasma membrane homeostasis and are important for cell polarity, migration, and ...from early to recycling ...recycling endosomes and their subsequent return to the ...
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