embryonic lethality
Conditional embryonic lethality to improve the sterile insect technique in Ceratitis capitata(Diptera: Tephritidae)
... the embryonic lethality line brings about two fluorescent markers (DsRed and EGFP), which are not only helpful during quality control but could also help in monitoring proc- ...itive embryonic LLs by ...
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Cancer susceptibility and embryonic lethality in Mob1a/1b double mutant mice
... partial embryonic lethality (Supple- mental Table 1) and develop liver cancers (Table 2), whereas Mob1a heterozygotes lacking Mob1b are all viable and free of liver ...
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Ubiquitous expression of Sry induces embryonic lethality related to suppression of Tie2/Tek expression
... We also examined the expression levels of Tie2/Tek in Sry-transgenic tissues, because Tie2/Tek has been re- ported to be involved in cardiovascular development. In wild-type embryos, Tie2/Tek expression levels were ...
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Identification of Quantitative Trait Loci responsible for embryonic lethality in mice assessed by ultrasonography
... In order to identify QTL related with embryonic death we examined 207 pregnant mice from 39 out of 53 available IRCS and from a control group consisting of 22-C57BL/6J animals (Table 1). The gestation was obtained ...
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Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2
... In contrast to mammalian cells, in budding yeast a single Cdk, the transcriptional product of the CDC28 gene, regulates diverse cell cycle transitions by associating with multiple stage-specific cyclins (Nasmyth, 1993; ...
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Injection of an SV40 transcriptional terminator causes embryonic lethality: a possible zebrafish model for screening nonhomologous end-joining inhibitors
... early embryonic development and similarity of tumor cell ...early embryonic development, we established a model that uses a transcrip- tional terminator signal fragment from the Simian virus 40 (SV40) to ...
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Embryonic Lethality and Tumorigenesis Caused by Segmental Aneuploidy on Mouse Chromosome 11
... Dp11(1)/1 and Dp11(1)/Dp11(1) mice have various recovered by this selection procedure. The Cre-loxP sys- abnormalities, while the Dp11(2)/1 and Dp11(2)/ tem described here obviates many of these problems. Dp11(2) mice do ...
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Heterochromatin Position Effects on Circularized Sex Chromosomes Cause Filicidal Embryonic Lethality in Drosophila melanogaster
... C HROMOSOMAL aberrations can have substantial nega- tive effects on the stability of the eukaryotic genome. In higher eukaryotes, chromosomes are normally linear. How- ever, abnormally circularized (“ring”) chromosomes ...
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apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A I transport rates in heterozygotes
... chylomicrons, VLDL, and LDL. To better understand the role of apo B in the body, we have used gene targeting in embryonic stem cells to create a null apo B allele in the mouse. Homozygous apo B deficiency led to ...
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Embryonic lethality is not sufficient to explain hourglass-like conservation of vertebrate embryos
... “mid-embryonic lethality hypoth- esis” is correct, the highest embryonic death rate should be observed around the conserved developmental period (24 hpf [18, 20]), which is marked as stage 28 ...
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Complete antithrombin deficiency in mice results in embryonic lethality
... (quantitative deficiency) and type II (qualitative defi- ciency), which includes a reactive defect, heparin-bind- ing site defect, and pleiotrophic effect (12–14). Although some cases of homozygous qualitative ...
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Hypotension, lipodystrophy, and insulin resistance in generalized PPARγ deficient mice rescued from embryonic lethality
... the embryonic lethality of global PPARγ knockout by breeding Mox2-Cre (MORE) mice with floxed PPARγ mice to inactivate PPARγ in the embryo but not in trophoblasts and created a general- ized PPARγ knockout ...
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Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene
... for embryonic lethality, we analysed the pattern of expression of ...the embryonic Arfgef2 gene is activated first at the 4-cell stage, suggesting an important role for embryonic ...
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The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis
... subunits relative to WT were pulled down using POLR3B R103H (Fig. 2a, Additional File 2: Table S1). The ratio of six of these subunits showed a statistically significant reduction in the mutant purifications com- pared ...
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Epiblast specific Snai1 deletion results in embryonic lethality due to multiple vascular defects
... We do not know at present whether Snai1 function is required autonomously within endothelial cells, or is required nonautonomously in the surrounding tissues. Due to the strong and widespread expression of Snai1 RNA ...
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A Limited Number of Caenorhabditis elegans Genes Are Readily Mutable to Dominant, Temperature-Sensitive Maternal-Effect Embryonic Lethality
... Previously, we described a collection of eight such domi- nant mutations found in six genes (MAINS et al. In the present study, we have doubled the number of dominant ts ma[r] ...
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Strain dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II–deficient mice
... B Gene expression of vascular remodeling factors at the vascular Humans with hetero wall with and without cuff injury in HCII+/+ white bars and HCII+/– mice black bars.. Real-time PCR a[r] ...
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Incompatibility between mitochondrial and nuclear genomes during oogenesis results in ovarian failure and embryonic lethality
... posteriorly down the ovariole as they mature through 14 morphologically defined stages (Fig. 1B). During early oogenesis, mitochondria greatly increase in number, with some transported into the oocyte, while others ...
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INVERSION POLYMORPHISM AND EMBRYONIC LETHALITY IN DROSOPHILA ROBUSTA
... robusta females heterozygous for an inversion in one chromosome was compared with that among progeny of two types of females heterozygous for long inversions in five arms of the[r] ...
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Dominant maternal-effect mutations causing embryonic lethality in Caenorhabditis elegans.
... M / M animals produced self-progeny embryos that arrested with no morphogenesis, but showed twitching and strong gut birefringence (22/22 embryos). T h e remaining embryos [r] ...
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