endoplasmic reticulum (ER) stress
Hydrogen Sulfide Plays an Important Protective Role through Influencing Endoplasmic Reticulum Stress in Diseases
... The endoplasmic reticulum is an important organelle responsible for protein synthesis, modification, folding, assembly and transport of new peptide ...the endoplasmic reticulum protein folding ...
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Endoplasmic Reticulum Stress Caused by Lipoprotein Accumulation Suppresses Immunity against Bacterial Pathogens and Contributes to Immunosenescence
... ER stress, gene ontology analysis for biological function of the upregulated genes showed enrichment in genes linked to ER stress and the UPR (Table ...
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Endoplasmic reticulum stress and inflammation in the central nervous system
... cellular stress by triggering effector mechanisms that can be grouped as adaptive, alarming or pro-apoptotic ...cellular stress, most notably the activation of inflammatory pathways, and ‘alarms’ the ...
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Endoplasmic Reticulum Stress Implicated in the Development of Renal Fibrosis
... ER stress resulted in ATF6 activation to the cATF6, which induced CHOP nuclear translocation and activated CHOP- dependent ...ER stress and consequent renal tubular apo- ptosis (see Figure ...ER ...
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Analysis of the Activities of the Inflammatory Cytokine Macrophage Migration Inhibitory Factor on Activation of Endoplasmic Reticulum Stress Responses
... ER stress as well as the UPR providing more activation potential by ATF6 and CHOP induced AKT activation (although this is cancelled out by IRS1 and mTORC2 in chronic cases) (Appenzeller-Herzog and Hall, ...
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S postconditioning engages the inhibition of endoplasmic reticulum stress
... mic reticulum lumen to launch UPR [17]. However, if stress is too intense or persistent, C/EBP homologous protein (CHOP), cas- pase-12, and JNK are activated, and ER/SR stress-induced apoptosis can ...
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Alginate oligosaccharide alleviates myocardial reperfusion injury by inhibiting nitrative and oxidative stress and endoplasmic reticulum stress-mediated apoptosis
... nitrosative/oxidative stress can decrease ER stress-mediated apoptosis, we did not identify the exact mechanism through which AOS pretreatment inhibits ER stress-mediated apop- ...
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Endoplasmic Reticulum Stress-Associated Chaperones, Bip/GRP78 and Calnexin are Overexpressed in Keratocystic Odontogenic Tumours
... ER stress and the resulting UPR may be associated with their ...ER stress markers BiP/ GRP78 and calnexin in the KCOTs but not in the PACs and the ...
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Autophagy induction and CHOP under expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress
... To explain the mechanism of the findings (that is, the increased autophagy in RASF), we compared the charac- teristics of OASF and RASF when exposed to ER stress. First, pro-inflammatory cytokines, including IL-6, ...
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Hyperactive TORC1 Sensitizes Yeast Cells to Endoplasmic Reticulum Stress by Compromising Cell Wall Integrity
... conserved in higher eukaryotes. Therefore, I rationalized that employing the model organism, Saccharomyces cerevisiae, would be a powerful tool to investigate the interplay between the UPR and other signaling networks. ...
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Autophagy activated via GRP78 to alleviate endoplasmic reticulum stress for cell survival in blue light-mediated damage of A2E-laden RPEs
... ER stress takes part in the blue light-mediated damage of A2E-laden RPEs ...ER stress-related apop- totic proteins, CHOP and caspase-12, increased after ...ER stress, GRP78 first dissociates from ER ...
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Endoplasmic reticulum stress: cell life and death decisions
... cell stress response, the unfold- ed protein response, which is aimed initially at compensating for damage but can eventually trigger cell death if ER dysfunction is severe or ...ER stress leads to cell ...
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Regulation of endoplasmic reticulum stress in adipose tissue metabolism
... Gregor et al. (Gregor, et al., 2009) have reported similar observations with regards to ER stress following malabsorptive bariatric surgery, i.e. gastric bypass, except for one notable difference. In their study, ...
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Endoplasmic reticulum stress and diabetic retinopathy
... ER stress (Chae et al ...ER stress (Dohm et al ...ER stress proteins such as CHOP, IRE1 α, or phospho-JNK (Lee et al ...ER stress-induced ...ER stress-mediated neuronal cell death by ...
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Endoplasmic reticulum stress in the pathogenesis of fibrotic disease
... Figure 1. Overview of ER stress–related signal- ing. Bip binds to accumulating misfolded pro- teins in the ER, leading to its dissociation from the three ER stress sensors, IRE1α, PERK, and ATF6. (i) ...
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The Endoplasmic Reticulum Stress Sensor Inositol Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production
... ER stress-induced ROS to disease pathology in different infectious or inflammatory contexts is war- ranted and may provide opportunities for therapeutic synergies with other treatments for infection and ...
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Endoplasmic reticulum stress and apoptosis
... In mitochondria-initiated apoptosis, BAX and BAK activation involves members of the BCL-2 family named BH3-only proteins. The presence of several BH3- only proteins, such as tBID, BIM, NOXA and PUMA, in the mitochondria ...
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Translational control in the endoplasmic reticulum stress response
... ER stress. In the context of the β cell, the induction of ER stress is a physiological con- sequence of the glucose-mediated increase in client protein ...
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Endoplasmic Reticulum Stress in Metabolic Disorders
... signaling, nutrient toxicity, oxidative stress) leading to inflammation and eventually to cell death.. ER stress induces IR and diabetes 15.[r] ...
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Endoplasmic reticulum stress in lung disease
... PERK activates the third arm of the UPR. It is regulated in a manner similar to IRE1, but once activated PERK recruits and phosphorylates the translation initiation factor eIF2 α [38] (figure 1). Reports that PERK can ...
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