endothelin converting enzyme
Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability
... Endothelin-converting enzyme-1c (ECE-1c) is a membrane metalloprotease involved in endothelin-1 synthesis, which has been shown in vitro to have a role in breast, ovary and prostate cancer ...
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Original Article Association of endothelin-converting enzyme-1 polymorphisms with risk of ischemic stroke in the Chinese Han population
... Stroke is a major cause of death and disability worldwide [1]. It is estimated that 41% to 79% of all stroke cases are ischemic stroke in China [2]. The significant increase in ischemic stroke burden has led to a series ...
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Neural peptidase endothelin converting enzyme 1 regulates endothelin 1–induced pruritus
... receptor (ETAR). Here, we have identified neural endothelin–converting enzyme 1 (ECE-1) as a key regulator of ET-1–induced pruritus and neural signaling of itch. We show here that ETAR, ET-1, and ...
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Disruption of ECE 1 and ECE 2 reveals a role for endothelin converting enzyme 2 in murine cardiac development
... Endothelin-converting enzyme-1 and -2 (ECE-1 and -2) are membrane-bound metalloproteases that can cleave biologically the inactive endothelin-1 (ET-1) precursor to form active ET-1 in ...
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Dual endothelin-converting enzyme/neutral endopeptidase blockade in rats with D-galactosamine-induced liver failure
... the liver cell damage seen in acute liver failure is not only due to direct effects of the precipitating drug, toxin, viral or other cause, but also due to a secondary release of proinflammatory and cytotoxic mediators ...
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Endothelin-Converting Enzyme-1 (ECE-1) Is Post-Transcriptionally Regulated by Alternative Polyadenylation
... Endothelin-converting enzyme-1 (ECE-1) is the enzyme predominantly responsible for producing active endothelin-1 (ET-1), a mitogenic peptide implicated in the aetiology of a number of ...
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Ontogeny of endothelins 1 and 3, their receptors, and endothelin converting enzyme 1 in the early human embryo
... deficient migration/proliferation/differentiation of neural crest cells, i.e., neurocristopathies. To bring new insight about the exact roles of ETs in development and the involvement of neural crest cells in these ...
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Endothelin and endothelin converting enzyme 1 in the fish gill: evolutionary and physiological perspectives
... by enzyme immunoassay and Tris-Tricine western blotting were unsuccessful, but measurements of EDN1 levels are necessary to fully understand the role of EDN1 cell signaling in the fish ...1996). Endothelin ...
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Verotoxin and ricin have novel effects on preproendothelin 1 expression but fail to modify nitric oxide synthase (ecNOS) expression and NO production in vascular endothelium
... bovine endothelin converting enzyme-1 (ECE-1) was generated by PCR (sense primer BE-1: 5 9 GCT CCT GGC GGC GGC ATT GGT G 3 9 ; antisense primer BE-2: 5 9 TCC TGG GGG ATG GTG ATG TTG G 3 9 ), cloned ...
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Identification of Alzheimer’s disease–associated rare coding variants in the ECE2 gene
... In this report, we describe the identification of rare coding mutations in the endothelin-converting enzyme 2 ( ECE2 ) gene in 1 late-onset AD family, and additional case-control cohor[r] ...
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Original Article Effect of single nucleotide polymorphisms of MDR1 C3435T and ECE-1 C-338A genes on the antihypertensive effect of irbesartan
... and endothelin- converting enzyme-1 (ECE-1) C-338A single nucleotide polymorphisms (SNPs) on the antihypertensive effect of irbesartan, and to provide guidance for individualized treatment of ...
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Oncogene dependency and the potential of targeted RNAi-based anti-cancer therapy.
... Abbreviations used: AD, adamantane; CDP, cyclodextrin-containing polymers; CML, chronic myeloid (or myelogenous) leukemia; ECE-1, endothelin converting enzyme 1; EGFR, [r] ...
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Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy
... were Endothelin receptor A (ETA; 1:5000 (rat) 1:100 (human); Alamone, Jerusalem, Israel), Endothe- lin receptor B (ETB; 1:2500 (rat) 1:500 (human); Alamone), Endothelin Converting Enzyme ...
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The association of angiotensin-converting enzyme with biomarkers for Alzheimer’s disease
... CSF ACE levels were more strongly associated with AD biomarkers than serum ACE levels. This indicates that CSF ACE, as might be expected, could reflect the activity of the brain RAS, thereby showing stronger as- ...
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Human Lung Angiotensin Converting Enzyme: PURIFICATION AND ANTIBODY PREPARATION
... angiotensin converting enzyme (EC ...pure enzyme was estimated to be 117 µmol/min per mg protein with the substrate hippuryl-l-histidyl-l- ...lung enzyme studies, catalytic activity was ...
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The angiotensin-converting enzyme (ACE) gene family of Anopheles gambiae
... In mammals, the two active sites of sACE are involved in the conversion of angiotensin I to angiotensin II and the hydrolysis of bradykinin, but only the N-domain is involved in N-acetyl SDKP metabolism [2]. Thus, ...
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The angiotensin converting enzyme (ACE) gene family of Anopheles gambiae
... In developing spermatids, an alternative intragenic pro- moter utilises exons 13–26 and generates a single domain ACE (gACE) which is largely identical to the C-terminal domain of somatic ACE [4,8]. Male mice lacking ...
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Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis
... Increasingly, it is apparent that elevated ACE levels are associated with aberrant repair and fibrosis, though the mechanisms defining the pathogenesis are poorly defined. Increased ACE expression in pulmo- nary ...
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Intervention using vitamin D for elevated urinary albumin in type 2 diabetes mellitus (IDEAL 2 Study): study protocol for a randomised controlled trial
... Angiotensin converting enzyme; ACEI: Angiotensin converting enzyme inhibitor; ACR: Albumin-creatinine ratio; ARB: Angiotensin receptor blocker; CKD: Chronic kidney disease; CRF: Case report ...
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Assessment of Angiotensin-Converting Enzyme Gene in Idiopathic Pulmonary Fibrosis
... angiotensin-converting enzyme (ACE) in lung parenchyma in a number of fibrotic lung diseases suggest that ACE may play a role in the pathogenesis of pulmonary fibrosis (4, ...
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