Endothelin Converting Enzyme-1
Endothelin-Converting Enzyme-1 (ECE-1) Is Post-Transcriptionally Regulated by Alternative Polyadenylation
... Endothelin-converting enzyme-1 (ECE-1) is the enzyme predominantly responsible for producing active endothelin-1 (ET-1), a mitogenic peptide implicated in ...
8
Original Article Association of endothelin-converting enzyme-1 polymorphisms with risk of ischemic stroke in the Chinese Han population
... The endothelin-converting enzyme-1 (ECE-1), a membrane bound metalloprotease, is in- volved in proteolytic processing of precursor big endothelin to activated ...
8
Endothelin and endothelin converting enzyme 1 in the fish gill: evolutionary and physiological perspectives
... by enzyme immunoassay and Tris-Tricine western blotting were unsuccessful, but measurements of EDN1 levels are necessary to fully understand the role of EDN1 cell signaling in the fish ...1996). Endothelin ...
12
Ontogeny of endothelins 1 and 3, their receptors, and endothelin converting enzyme 1 in the early human embryo
... deficient migration/proliferation/differentiation of neural crest cells, i.e., neurocristopathies. To bring new insight about the exact roles of ETs in development and the involvement of neural crest cells in these ...
12
Neural peptidase endothelin converting enzyme 1 regulates endothelin 1–induced pruritus
... The technical assistance of Heike Hinte, Diana Below, Ron- ald Manlapaz, Andrea Poppe, and Wendy Cedron is gratefully acknowledged. We thank Fabian Bandrowski, Randal Maile, and Ingo H. Engels for critically reading the ...
14
Oncogene dependency and the potential of targeted RNAi-based anti-cancer therapy.
... Abbreviations used: AD, adamantane; CDP, cyclodextrin-containing polymers; CML, chronic myeloid (or myelogenous) leukemia; ECE-1, endothelin converting enzyme 1; EGFR, [r] ...
33
Disruption of ECE 1 and ECE 2 reveals a role for endothelin converting enzyme 2 in murine cardiac development
... Endothelin-converting enzyme-1 and -2 (ECE-1 and -2) are membrane-bound metalloproteases that can cleave biologically the inactive endothelin-1 (ET-1) precursor to ...
11
Original Article Effect of single nucleotide polymorphisms of MDR1 C3435T and ECE-1 C-338A genes on the antihypertensive effect of irbesartan
... protein 1 (MDR1) C3435T and endothelin- converting enzyme-1 (ECE-1) C-338A single nucleotide polymorphisms (SNPs) on the antihypertensive effect of irbesartan, and to provide ...
8
Verotoxin and ricin have novel effects on preproendothelin 1 expression but fail to modify nitric oxide synthase (ecNOS) expression and NO production in vascular endothelium
... (VTs) 1 and 2 (Shiga toxin 1 and 2) with vascular en- dothelium is believed to play a central role in the pathogen- esis of the thrombotic microangiopathy and ischemic lesions characteristic of hemolytic ...
12
Angiotensin converting enzyme inhibition modulates endogenous endothelin in chronic canine thoracic inferior vena caval constriction
... Immunohistochemistry. Immunohistochemical staining for ET in cardiac atria, lung parenchyma, and renal medulla was performed as described previously (6). Briefly, paraffin embedded tissue was cut to 6 m m and placed on ...
8
Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy
... 9.0), 1 mM ...were Endothelin receptor A (ETA; 1:5000 (rat) 1:100 (human); Alamone, Jerusalem, Israel), Endothe- lin receptor B (ETB; 1:2500 (rat) 1:500 (human); Alamone), ...
12
Dual endothelin-converting enzyme/neutral endopeptidase blockade in rats with D-galactosamine-induced liver failure
... histology; 1, minor necrosis; 2, widely distributed patchy necrosis of he- patocytes; and 3, complete lobular disruption and diffuse hepatocyte ...histology; 1, minimal perilobular inflamma- tory reaction; ...
5
Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability
... An in silico analysis showed that cytoplasmic N-terminal end of ECE-1c contains three conserved residues fulfilling the phosphorylation consensus for CK2 (Figure 2A). Thus, in order to get a first indication in cell of ...
12
Leucine and ACE inhibitors as therapies for sarcopenia (LACE trial): study protocol for a randomised controlled trial
... angiotensin converting enzyme inhibition) that can po- tentially improve muscle mass and function in people with sarcopenia as defined by the European Working Group on Sarcopenia (EWGSOP) ...
11
Urinary angiotensinogen level is associated with potassium homeostasis and clinical outcome in patients with polycystic kidney disease: a prospective cohort study
... (K > 5.5) (Fig. 3). The lower prevalence of hyperkalemia in PKD was prominent in the early CKD stages, and attenuated with decline of renal function. In the multivari- able logistic regression analysis, we built up ...
12
Effective treatment of hypertension by recombinant Lactobacillus plantarum expressing angiotensin converting enzyme inhibitory peptide
... angiotensin converting enzyme; ACEIP: angiotensin converting enzyme inhibitory peptides; RAS: renin-angiotensin system; LAB: lactic acid bacteria; SppIP: sakasin-P; SHR: spontaneously ...
9
Metformin: an old but still the best treatment for type 2 diabetes
... Angiotensin converting enzyme; AD: Alzheimeir disease; AGE: Advanced glycosilation end product; AMPK: Adenosine monophosfatase protein kinase; BACE 1: Beta-amyloid cleaving enzyme- 1; ...
15
Intervention using vitamin D for elevated urinary albumin in type 2 diabetes mellitus (IDEAL 2 Study): study protocol for a randomised controlled trial
... Angiotensin converting enzyme; ACEI: Angiotensin converting enzyme inhibitor; ACR: Albumin-creatinine ratio; ARB: Angiotensin receptor blocker; CKD: Chronic kidney disease; CRF: Case report ...
10
Angiotensin Converting Enzyme and Angiotensin II Type 1 Receptor Polymorphisms in Patients with Coronary Aneurysms
... Epidemiological and clinical characteristics were collected by trained physicians. Coronary angiograms were ana- lysed by two experienced interventionnal cardiologists. The number of non significant (≤ 50%) or ...
7
Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region
... protease enzyme of the RAAS that regulates blood pressure by catalyzing the conversion of ANG I into ANG II (7). ANG II is a potent vazoconstrictive molecule that plays a key role in modulating vascular tone. ANG ...
5