engineered cartilage
Chm-1 gene-modified bone marrow mesenchymal stem cells maintain the chondrogenic phenotype of tissue-engineered cartilage
... for cartilage tissue engineering [8]. However, tissue-engineered cartilage constructed by chondrogenic induction of MSCs exhibits a hypertrophic phenotype and extensive calcification of the ...
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Evaluation of in vivo migration of chondrocytes from tissue engineered cartilage that was subcutaneously transplanted in mouse model
... tissue-engineered cartilage, we had syngenically transplanted the tissue-engi- neered cartilage using chondrocytes harvested from EGFP-transgenic mice into subcutaneous pocket of wild type mice, and ...
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Effect of a degraded core on the mechanical behaviour of tissue engineered cartilage constructs: a poro elastic finite element analysis
... of cartilage component is within the construct ...the engineered tissue is of poorer quality than is actually the ...of engineered cartilage constructs with IGF-I during the culture period has ...
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Cytokine preconditioning of engineered cartilage provides protection against interleukin 1 insult
... promote engineered cartilage as a clinically relevant replacement tissue, the construct must be able to survive the chemical and mechanical loads that are imparted upon ...tional engineered ...
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Autologous cell derived, tissue engineered cartilage for repairing articular cartilage lesions in the knee: study protocol for a randomized controlled trial
... articular cartilage, and functional recovery is not ...damaged cartilage. We prepared biomimetic, tissue-engineered cartilage scaffolds optimized for biochemical composition and structural ...
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Biological Evaluation of Tissue Engineered Cartilage Using Thermoresponsive Poly(N isopropylacrylamide) Grafted Hyaluronan
... for cartilage tissue ...tissue-engineered cartilage over time in vitro. Cartilage- related gene expression patterns, which were tested in rabbit normal chondrocytes embedded in the hydrogel, ...
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<p>Experimental study of tissue-engineered cartilage allograft with RNAi chondrocytes in vivo</p>
... is composed of chondrocytes (cartilage cells) embedded in a highly specialized extracellular matrix (ECM). Chondrocytes constitutively express class I and, in some species, class II major histocompatibility ...
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Usefulness of Agarose Mold as a Storage Container for Three Dimensional Tissue Engineered Cartilage
... In the group contained in the agarose mold and stored at 4˚C Figure 4, Group AL and the group in the agarose mold, combined with medium, and stored at 37˚C Figure 4, Group B, approximate[r] ...
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The Composition of Engineered Cartilage at the Time of Implantation Determines the Likelihood of Regenerating Tissue with a Normal Collagen Architecture
... The remaining halves were dehydrated and embedded in paraffin wax. Constructs were sectioned perpendicular to the disc face yielding 5 μm thick sections. Sections were stained with either 1 % alcian blue 8GX (Sigma- ...
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Porous Scaffolds Derived from Devitalized Tissue Engineered Cartilaginous Matrix Support Chondrogenesis of Adult Stem Cells
... E., Engineered cartilage via self-assembled hMSC sheets with incorporated biodegradable gelatin microspheres releasing transforming growth ...tissue engineered hypertrophic cartilage as a ...
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Biochemical Markers of the Mechanical Quality of Engineered Hyaline Cartilage
... modulus) from engineered constructs cultured for either, 20, 30, 40 or 80 days was found to positively correlate with GAG, collagen I and collagen II content. The Young’s modulus is determined by unconfined ...
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Human telomerase reverse transcriptase and glucose regulated protein 78 increase the life span of articular chondrocytes and their repair potential
... as cartilage erosion or severe synovial proliferation, were observed in any surgically treated ...tissue- engineered cartilage grown from hTERT- and GRP78- transfected ORA chondrocytes, the ...
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Strain distribution of repaired articular cartilage defects by tissue engineering under compression loading
... articular cartilage has been predicted theoretically and ana- lyzed experimentally in in vitro systems, few reports focus on what the mechanical condition is after repairing cartilage defects by ...
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Differential direct effects of cyclo oxygenase 1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitrostudy
... OA cartilage in vitro, as previously demonstrated, although there was a tendency toward such an ...on cartilage, recent data showed a beneficial effect of celecoxib in normal cartilage under ...
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The Effects Of Surface Curvature On Biomechanical Behaviour Of Articular Cartilage
... the cartilage can become so thin that it does not cover the ends of the ...of cartilage, the wearing of bone and the bony spurs can change the shape of your joint, forcing the bones to be out of their ...
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MMP13 is a critical target gene during the progression of osteoarthritis
... Knee joints from each group were harvested and prepared for sectioning and analysis. Samples were fixed in 10% neutral buffered formalin (VWR, Radnor, PA, USA) for three days, then decalcified with formic acid (Decal ...
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Object Identification for Pure Object Oriented Cross Languages Software Development
... is engineered by the requirement design, and in addition, the base domain is engineered by the domain foresting (sub-domain) rules, for objects extraction using step- to-next sequential tasks from the each ...
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Repair of bone defects in vivo using tissue engineered hypertrophic cartilage grafts produced from nasal chondrocytes
... ossification. Cartilage can withstand lower oxygen concentrations than bone tissue containing osteoblasts and mesenchymal stem cells ...of cartilage allows for both the culture of larger grafts, as well as ...
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Icariin conditioned serum engineered with hyaluronic acid promote repair of articular cartilage defects in rabbit knees
... Following trauma or degenerative pathology, native osteochondral repair is often inadequate due to the in- herent properties of the cartilage. Recently, drug-loaded materials have been proposed as a potential ...
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Biomarkers in Osteoarthritis
... knee cartilage defects grades over 2 years in 2 different ...patellar cartilage defect (long arrow) is grade 2 at baseline and grade 4 at ...tibial cartilage defect (short arrow) is grade 1 at ...
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