Enterovirus D68
Molecular Evolution and Intraclade Recombination of Enterovirus D68 during the 2014 Outbreak in the United States
... In August 2014, an outbreak of enterovirus D68 (EV-D68) occurred in North America, causing severe respiratory disease in chil- dren. Due to a lack of complete genome sequence data, there is only a ...
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Genomic Analyses of Acute Flaccid Myelitis Cases among a Cluster in Arizona Provide Further Evidence of Enterovirus D68 Role
... years, enterovirus D68 (EV-D68) has been associated with serious neurologic illnesses, including acute flaccid myelitis (AFM), frequently preceded by respiratory ...
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Validating Enterovirus D68-2Apro as an Antiviral Drug Target and the Discovery of Telaprevir as a Potent D68-2Apro Inhibitor
... 2. Midgley CM, Watson JT, Nix WA, Curns AT, Rogers SL, Brown BA, Conover C, Dominguez SR, Feikin DR, Gray S, Hassan F, Hoferka S, Jackson MA, Johnson D, Leshem E, Miller L, Nichols JB, Nyquist AC, Obringer E, Patel A, ...
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Enterovirus D68 infection induces IL-17–dependent neutrophilic airway inflammation and hyperresponsiveness
... Enterovirus D68 (EV-D68) shares biologic features with rhinovirus ...EV- D68 induced airway inflammation, expression of cytokines (TNF-a, IL-6, IL-12b, IL-17A, CXCL1, CXCL2, CXCL10, and CCL2), ...
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Development and Evaluation of an Enterovirus D68 Real Time Reverse Transcriptase PCR Assay
... uman enterovirus D68 (EV-D68) was first isolated from sam- ples obtained in California in 1962 from four children with pneumonia and bronchiolitis ...2014 enterovirus/rhinovirus season in the ...
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Crystal Structure and Thermostability Characterization of Enterovirus D68 3Dpol
... IMPORTANCE Enterovirus D68 (EV-D68) is an emerging viral pathogen, which caused sporadic infections around the world. In recent years, epidemiology studies have re- ported an increasing number of ...
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Contemporary Circulating Enterovirus D68 Strains Have Acquired the Capacity for Viral Entry and Replication in Human Neuronal Cells
... ABSTRACT Enterovirus D68 (EV-D68) has historically been associated with respira- tory illnesses. However, in the summers of 2014 and 2016, EV-D68 outbreaks coin- cided with a spike in ...
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Evaluation of a Real Time Reverse Transcription PCR Assay for Detection of Enterovirus D68 in Clinical Samples from an Outbreak in New York State in 2014
... including enterovirus A to D and rhi- novirus A to C, that commonly cause human disease (1, ...2). Enterovirus D68 (EV-D68) was first recovered from patients with respiratory illness in ...
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Neurotropism of Enterovirus D68 Isolates Is Independent of Sialic Acid and Is Not a Recently Acquired Phenotype
... and enterovirus infections, and occur in children under the age of 6 ...years. Enterovirus D68 (EV-D68) was first isolated from children with pneu- monia in 1962, but an association with AFM ...
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3C Protease of Enterovirus D68 Inhibits Cellular Defense Mediated by Interferon Regulatory Factor 7
... EV-D68 infection does not stimulate the type I IFN response in HeLa cells. Innate antiviral immunity plays a pivotal role in con- trolling virus infection (36). To assess the impact of EV-D68, we ...
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Molecular epidemiological study of enterovirus D68 in hospitalised children in Hong Kong in 2014–2015 and their complete coding sequences
... Figure 1 Monthly distribution of EV/RV-positive NPA specimens detected in hospitalised (A) preschool-age children (0–5 years), (B) school-age children (5–17 years) and (C) adults (above 17 years) in Prince of Wales ...
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MRI Findings in Children with Acute Flaccid Paralysis and Cranial Nerve Dysfunction Occurring during the 2014 Enterovirus D68 Outbreak
... This series of children presenting with neurologic disease after a respiratory illness during an EV-D68 outbreak shares a character- istic pattern of MR imaging findings previously described in past outbreaks of ...
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Disruption of MDA5-Mediated Innate Immune Responses by the 3C Proteins of Coxsackievirus A16, Coxsackievirus A6, and Enterovirus D68
... CV-A16, CV-A6, and EV-D68 suppress the type I IFN response triggered by RNA virus infection. It has been established that infection with the RNA virus Sendai virus (SeV) can stimulate the expression of interferons ...
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Chronic Enterovirus D68 Bronchiolitis Causing Severe Respiratory Insufficiency
... EV D68 infection of the lungs was enormous, but the prevalence of chronic viral bronchitis/bronchiolitis following countless cases of acute respiratory tract infec- tion can never be defined without clear ...
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Acute flaccid myelitis associated with enterovirus D68 infection in an otherwise healthy child
... of enterovirus (EV)-D68-associated acute flaccid myelitis (AFM) is essential to understand how the virus causes neurological damage and to characterize EV-D68 strains associated with ...
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Acute Flaccid Myelitis Surveillance: A Signal Through the Noise
... during the intervening years (Fig 1). It is already evident in the Ayers et al 1 study and among US AFM cases overall from 2014 to 2018 that enterovirus-D68 has been the predominant pathogen detected. 1,3,4 ...
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High Frequency of Human Enterovirus Species C Circulation in Madagascar
... Studies of vaccine-derived poliovirus outbreaks, including the one that recently occurred in Madagascar, have shown that all of the implicated strains resulted from recombination be- tween vaccine poliovirus and ...
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Adverse effects of maternal enterovirus infection on the pregnancy outcome: a prospective and retrospective pilot study
... Fetal enterovirus infection has been described to be re- sponsible for sonographic findings that include cerebral ventriculomegaly, cardiomyopathy with ventricular dys- function [19], and polyhydramnios associated ...
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Maternal Antibodies in Breast Milk Protect the Child From Enterovirus Infections
... month). Enterovirus in- fections were diagnosed by virus isolation from serial stool samples whereas serum samples were not ana- ...class enterovirus antibodies in breast milk, which seemed to be more ...
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Enterovirus serotypes in patients with central nervous system and respiratory infections in Viet Nam 1997–2010
... four Enterovirus species (A-D) were identified, including EV-A71 and ...EV-D68. Enterovirus B was associated with viral meningitis in children and ...four Enterovirus species were found in ...
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