envelope glycoproteins
Characterization of the Envelope Glycoproteins Associated with Infectious Hepatitis C Virus
... two glycoproteins, namely, E1 and E2, which have been shown to assemble as a noncovalent ...(HCV) glycoproteins have only been studied so far in heterologous expression systems, and their organization at ...
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Characterization of Functional Hepatitis C Virus Envelope Glycoproteins
... HCV envelope glycoproteins expressed in 293T cell are modified by Golgi enzymes, their resistance to endo H treatment was de- ...that glycoproteins have moved from the ER to at least the medial and ...
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A V3 Loop-Dependent gp120 Element Disrupted by CD4 Binding Stabilizes the Human Immunodeficiency Virus Envelope Glycoprotein Trimer
... HIV-1 envelope gly- ...HIV-1 envelope glycoproteins were as- ...trimeric envelope glycoprotein complex, as well as for chemokine receptor ...
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Stoichiometry of Antibody Neutralization of Human Immunodeficiency Virus Type 1
... intact envelope glyco- protein trimers per virion (12, 20, 30, 85), by spontaneous and ligand-induced dissociation (shedding) of gp120 from the en- velope glycoprotein complexes (40, 50, 59), and by potential ...
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Identification of New Functional Regions in Hepatitis C Virus Envelope Glycoprotein E2
... E2 envelope glycoproteins form large covalent complexes stabilized by disulfide bridges, whereas the intracellular forms of these proteins assemble as noncovalent heterodimers ...HCV envelope ...
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Apoptosis of uninfected cells induced by HIV envelope glycoproteins
... HIV envelope glycoproteins (Env) play a crucial role in transducing this apoptotic signal after binding to its receptors, the CD4 molecule and a coreceptor, essentially CCR5 and ...
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Identification of Novel Functions for Hepatitis C Virus Envelope Glycoprotein E1 in Virus Entry and Assembly
... CD81 interaction and immunoprecipitation assays. CD81 pulldown and immunoprecipitation experiments were performed as previously described (59). Cells were lysed in PBS lysis buffer (1% Triton X-100, 20 mM NEM, 2 mM EDTA, ...
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Receptor-binding domain of murine leukemia virus envelope glycoproteins.
... in envelope-receptor ...X envelope glycoproteins to their receptors has been previously suggested (1, ...in envelope-receptor interac- tions by different nonexclusive ...terminal ...
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Identification of Key Residues in Subgroup A Avian Leukosis Virus Envelope Determining Receptor Binding Affinity and Infectivity of Cells Expressing Chicken or Quail Tva Receptor
... the envelope glycoproteins for ...mutant envelope glycoproteins retain near-wild-type binding affinities for the soluble chicken Tva receptor but have significantly lower bind- ing affinities ...
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Caprine Arthritis-Encephalitis Virus Envelope Surface Glycoprotein Regions Interacting with the Transmembrane Glycoprotein: Structural and Functional Parallels with Human Immunodeficiency Virus Type 1 gp120
... lected for site-directed mutagenesis to test their role on inter- actions with gp38. These sites and their position relative to the regions of sequence similarity with HIV-1 gp120 are shown in Fig. 1A, B, and C. Proline ...
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The Signal Peptide of the Junín Arenavirus Envelope Glycoprotein Is Myristoylated and Forms an Essential Subunit of the Mature G1-G2 Complex
... the envelope glycoprotein ...virus envelope glycoprotein complex to mem- brane ...of envelope glycoprotein within rafts has been shown to facilitate the highly cooperative process of membrane fusion ...
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Endocytosis of the Nipah Virus Glycoproteins
... viral envelope pro- teins from the cell surface as well as any other mechanism to downmodulate glycoproteins from the cell surface may play a significant role in viral pathogenesis by limiting cytopathoge- ...
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N-Glycans on the Nipah Virus Attachment Glycoprotein Modulate Fusion and Viral Entry as They Protect against Antibody Neutralization
... In addition, it appeared that mutants G2 and G6 were ex- pressed at lower levels than the wild-type G glycoprotein in whole- cell lysates (Fig. 1B). To determine whether the levels of whole-cell expression corresponded ...
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Regulation of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Fusion by a Membrane-Interactive Domain in the gp41 Cytoplasmic Tail
... A long CT of approximately 150 amino acids is a hallmark of most lentiviral envelope glycoproteins, including those of HIV-1, HIV-2, SIV, equine infectious anemia virus, and visna virus. Although the ...
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Cell Fusion Activities of Hantaan Virus Envelope Glycoproteins
... pared as antigen-presenting cells as was done previously(2). HTNV strain 76118, clone 1 (8, 23) was propagated in Vero E6 cells. The culture supernatant was collected 10 days after inoculation and stored at ⫺80°C for use ...
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Cytoplasmic Domain of Sendai Virus HN Protein Contains a Specific Sequence Required for Its Incorporation into Virions
... Envelope viruses are released from infected cells by budding at the cellular membrane. During the budding process, viral proteins are preferentially incorporated into progeny virions whereas cellular proteins are ...
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