epithelial-mesenchymal transition
MicroRNAs and epithelial-mesenchymal transition in prostate cancer
... cells. Epithelial- mesenchymal transition (EMT), a process characterized by decreased expression of epithelial genes and increased expression of mesenchymal genes, plays a critical role ...
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A Theoretical Model of the Wnt Signaling Pathway in the Epithelial Mesenchymal Transition
... the epithelial mesenchymal transition (EMT), which is triggered by cues from inflammatory and stromal cells in the ...allows epithelial cells to lose their highly adhesive nature and instead ...
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Gli promotes epithelial-mesenchymal transition in human lung adenocarcinomas
... cancer. Epithelial-mesenchymal transition (EMT) is required for tumor invasion/metastasis and the components that control this process are potential therapeutic ...
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Epithelial mesenchymal transition and its implications for fibrosis
... or transition” are comingled inap- propriately with the term “epithelial-mesenchymal ...(16). Epithelial- mesenchymal interaction refers to proximate paracrine cross-talk between tissue ...
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A proximal activator of transcription in epithelial mesenchymal transition
... for epithelial- mesenchymal transition (EMT) are increasingly more complex (1, ...epithelia transition to new morphology and motility based on its ability to influence levels of intracellular ...
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EPITHELIAL–MESENCHYMAL TRANSITION: ROLE OF TRANSCRIPTION FACTORS WITH EMPHASIS ON SIX1
... an epithelial- mesenchymal transition (EMT) that is in part dependent on its ability to increase ...The epithelial mesenchymal transition (EMT) is regulated at all levels og gene ...
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Epithelial mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
... Epithelial-mesenchymal transition (EMT) has become widely accepted as a mechanism by which injured renal tubular cells transform into mesenchymal cells that contribute to the development of ...
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Aquaporin 3 promotes epithelial-mesenchymal transition in gastric cancer
... that epithelial- mesenchymal transition (EMT) contributes to invasion and metastasis ...which epithelial cells shed certain characteristics (such as cell-cell adhesion, planar and apical-basal ...
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Clinical significance of epithelial-mesenchymal transition
... of epithelial-mesenchymal transition (EMT), a process where cells change their epithelial towards a mesenchymal phenotype, has gained overwhelming attention especially in the cancer ...
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Sulforaphane attenuates pulmonary fibrosis by inhibiting the epithelial-mesenchymal transition
... 1-induced epithelial-mesenchymal transition (EMT) in A549 epithelial ...in epithelial morphology with original magnification, × 200 ...the epithelial cell marker (E-cadherin), ...
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Tetraspanin in oncogenic epithelial mesenchymal transition
... Members of the L6 family of membrane proteins, a branch of the tetraspanin superfamily, are overexpressed in tumor cells from many types of cancers. However, direct evidence of their oncogenic activity has not been ...
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Epithelial-Mesenchymal Transition in tumor microenvironment
... and epithelial-mesenchymal transition (EMT) is of potential importance for this process ...whereby epithelial cell layers lose polarity together with cell-cell contacts and then undergo a dra- ...
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Emerging roles of epithelial-mesenchymal transition in hematological malignancies
... EMT: Epithelial-mesenchymal transition; EMT-TFs: epithelial-mesenchymal transition-transcription factors; GSK- β : Glycogen synthase kinas- β ; HSCs: Hematopoietic stem cells; ...
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Regulation of Epithelial-Mesenchymal Transition by Transcriptional Factors in Cervical Carcinoma
... whereas mesenchymal cells loose cell adhesion and have a front- back cell polarity ...[9]. Epithelial cells can be converted to mesenchymal cells through a epithelial-mesenchymal ...
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Relevance of the stroma and epithelial mesenchymal transition (EMT) for the rheumatic diseases
... have mesenchymal appearing cells that stain with an antibody to phosphorylated Smad 2/3, suggesting engagement of TGF- β receptors and activation of ECM through the TGF-β signaling pathway [73] (Figure ...
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Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transition
... in mesenchymal versus luminal types of breast cancer [38] are over-represented in GC16 and GC19 (fold enrichment over background: ...of epithelial origin have a common EMT-associated epigenetic mechanism ...
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RNF8 promotes epithelial-mesenchymal transition of breast cancer cells
... polarized epithelial cells lost their cell-cell junc- tions and converted into individual, non-polarized, motile and invasive mesenchymal cells [3, ...in epithelial maintenance, including CDH1 gene, ...
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mAChRs activation induces epithelial-mesenchymal transition on lung epithelial cells
... alveolar epithelial cell line A549 is widely acknowledged as a relevant model of type II alveolar epi- thelial cells and the ability to undergo EMT in vitro has been confirmed ...alveolar epithelial cells, ...
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The basics of epithelial mesenchymal transition
... MMP-9. Epithelial cells come under the influence of these sig- naling molecules and, acting together with the inflammatory cells, induce basement membrane damage and focal degradation of type IV collagen and ...
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The translational significance of epithelial-mesenchymal transition in head and neck cancer
... Epigenetic modulation of key developmental and EMT- driven pathways is another area of active translational investigation in HNC. Various studies have demonstrated epigenetic down-regulation of key epithelial ...
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