Epithelial-Mesenchymal Transition (EMT)
Tetraspanin in oncogenic epithelial mesenchymal transition
... However, direct evidence of their oncogenic activity has not been previously shown. In this issue of the JCI, Lee et al. demonstrate that overexpression of the tetraspanin superfamily member TM4SF5 in human ...
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Clinical significance of epithelial-mesenchymal transition
... of epithelial-mesenchymal transition (EMT), a process where cells change their epithelial towards a mesenchymal phenotype, has gained overwhelming attention especially in the cancer ...
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Epithelial mesenchymal transition and its implications for fibrosis
... or transition” are comingled inap- propriately with the term “epithelial-mesenchymal ...(16). Epithelial- mesenchymal interaction refers to proximate paracrine cross-talk between tissue ...
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A proximal activator of transcription in epithelial mesenchymal transition
... EGF, epithelial growth factor; EMT, epithelial-mesenchymal transition; FSP1, fibroblast-specific protein 1; FTS-1, fibroblast transcription site–1; HMGA2, high mobility group A2; KAP-1, ...
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MicroRNAs and epithelial-mesenchymal transition in prostate cancer
... cells. Epithelial- mesenchymal transition (EMT), a process characterized by decreased expression of epithelial genes and increased expression of mesenchymal genes, plays a critical role ...
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Epithelial Mesenchymal Transition: a double-edged sword
... Abstract Epithelial mesenchymal transition (EMT) is a physiological process necessary to normal embryologic ...this transition can be perverted and signaling pathways have different ...
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MicroRNAs and epithelial-mesenchymal transition in prostate cancer.
... cells. Epithelial- mesenchymal transition (EMT), a process characterized by decreased expression of epithelial genes and increased expression of mesenchymal genes, plays a critical role ...
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MET: roles in epithelial mesenchymal transition and cancer stemness
... Abstract: In a number of cancers, deregulated MET pathway leads to aberrantly activated proliferative and invasive signaling programs that promote malignant transformation, cell motility and migration, angiogenesis, ...
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Regulation of epithelial mesenchymal transition by protein lysine acetylation
... The epithelial-mesenchymal transition (EMT) is a vital driver of tumor ...which epithelial cells undergo morphogenetic changes with loss of apical-basal polar- ity, but acquire spindle-shaped ...
Emerging roles of epithelial-mesenchymal transition in hematological malignancies
... EMT: Epithelial-mesenchymal transition; EMT-TFs: epithelial-mesenchymal transition-transcription factors; GSK- β : Glycogen synthase kinas- β ; HSCs: Hematopoietic stem cells; ...
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SMYD3 promotes the epithelial-mesenchymal transition in breast cancer
... -induced epithelial– mesenchymal transition (EMT) in mammary epithelial cells, promoting mesenchymal and EMT transcrip- tion factors ...attenuates mesenchymal genes ...
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Tackle Epithelial-Mesenchymal Transition with Epigenetic Drugs in Cancer
... EPITHELIAL-MESENCHYMAL TRANSITION AND HISTONE MODIFICATION Acetylation Lysine acetylation of histone tails, one of the most frequently found PTMs, is catalyzed by a variety of transcriptional co- ...
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Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Epithelial-Mesenchymal Transition
... Abstract: Epithelial–mesenchymal transition (EMT) is a process that takes place during embryonic development, wound healing, and under some pathological processes, including fibrosis and tumor ...
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FOXM1 confers to epithelial-mesenchymal transition, stemness and chemoresistance in epithelial ovarian carcinoma cells
... in epithelial ovarian ...the epithelial-mesenchymal transition (EMT) and a stem cell phenotype in ovarian cancer ...of epithelial markers and the upregulation of mesenchymal ...
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Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk
... identified. Epithelial-mesenchymal transition (EMT) is a fundamental embryonic process whereby epithelial cells assume mesenchymal characteristics to facilitate migration through the ...
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Epithelial mesenchymal transition, cancer stem cells and treatment resistance
... Epithelial–mesenchymal transition in cancer stem cells EMT proceeds in a series of steps, where cells eventually acquire a more spindle-shaped ...
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Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transition
... with epithelial-mesenchymal transition We attempted to construct a representative list of genes relevant to ...the epithelial-mesenchymal ...
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Drivers of epithelial mesenchymal transition in chronic obstructive pulmonary disease
... Figure 1.5. A simplified schematic diagram showing the major potential drivers of epithelial– mesenchymal transition. These pathways are complex and inextricably interconnected. The Smad pathway for ...
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The basics of epithelial mesenchymal transition
... of mesenchymal phenotype, the mechanisms of EMT induction and progression vary dramatically from one setting to ...activated mesenchymal cells, notably myofibroblasts that produce excessive amounts of col- ...
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Epithelial-Mesenchymal Transition in tumor microenvironment
... cell Epithelial-Mesenchymal Transitions (EMT) in tumor ...hypoxia, mesenchymal stem cells all can effectively lead the epithelial-to-mesenchymal transition (EMT) of tumor ...
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