epithelial–mesenchymal transitions
Epithelial mesenchymal transitions and hepatocarcinogenesis
... Epithelial-mesenchymal transitions (EMTs) are believed to play a role in invasion and metastasis of many types of tumors. In this issue of the JCI, Chen et al. show that a gene that has been ...
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Epithelial mesenchymal transitions: the importance of changing cell state in development and disease
... adherent epithelial cells into individual migratory cells that can invade the extracellular matrix are known collectively as epithelial-mesenchymal transition ...
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Traditional Chinese Medicine and regulatory roles on epithelial–mesenchymal transitions
... also secrete chemokines and metalloproteases (MMPs), notably MMP-2, MMP-3, and MMP-9 [51]. During skin wound-healing, keratinocytes undergo a partial EMT process. These keratinocytes, together with surround- ing cells ...
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Epithelial Mesenchymal Transitions: Basics, Clinical Applicability & Recent Updates
... Abstract: Epithelial mesenchymal transition is an integral step in embryogenesis and wound ...motile, mesenchymal like cells develop from epithelial ...
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Epithelial Mesenchymal Transitions in development and disease: old views and new perspectives
... Anatomy for which he generated all the histological slides and drawings. It was in this book that he described the histopathology of many diseases in detail including an extremely interesting chapter on carcinomas. His ...
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FGF controls epithelial mesenchymal transitions during gastrulation by regulating cell division and apicobasal polarity
... an epithelial state and/or retain mesenchymal characteristics, we examined expression of E-Cadherin (E-Cad) and N-Cadherin (N- Cad), cell-adhesion molecules typically associated with either ...
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Epithelial mesenchymal transitions: insights from development
... Fig. 3. Epithelial-mesenchymal transition in trunk neural crest cells in chick embryos. BMP4 and Wnt1 signals stimulate neural crest delamination. BMP4 and Wnt1 signals are antagonized by Noggin, which in ...
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Biomarkers for epithelial mesenchymal transitions
... that epithelial and endothelial cells enjoy some of this plasticity, which is easily demonstrated by studying the process of epithelial-mesenchymal transition ...of epithelial and endothelial ...
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Contribution of epithelial-mesenchymal transitions to organogenesis and cancer metastasis.
... The epithelial-to-mesenchymal transition (EMT) describes a cellular process during which epithelial cells transition to a mesenchymal cell ...completely epithelial to a fully ...
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<p>HGF/MET Regulated Epithelial-Mesenchymal Transitions And Metastasis By FOSL2 In Non-Small Cell Lung Cancer</p>
... procedures and transform them into mesenchymal cells. The main characteristics of EMT include the decrease of cell adhesion molecules E-cadherin, the transformation of the cytokeratin cytoskeleton into the ...
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<p>KGF Is Delivered to Inflammatory and Induces the Epithelial Hyperplasia in Trinitrobenzene Sulfonic Acid-Induced Ulcerative Colitis Rats</p>
... intestinal epithelial crypt damage and enhanced intestinal mucosal ...mucosal epithelial cells to reduce the decrease of tight junction protein expression induced by TNBS-induced colitis to protect ...
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Cellular interactions in the pathogenesis of interstitial lung diseases
... Traditionally, mast cells have been recognised as the effectors of IgE-mediated allergic inflammation. More recently, their role has been highlighted in other disease processes such as fibrogenesis [120]. Mast cells and ...
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Expression of zinc finger transcription factors (ZNF143 and ZNF281) in serous borderline ovarian tumors and low-grade ovarian cancers
... ZNF143 regulates many cell cycle-associated genes, and binding sites for ZNF143 have been found in ap- proximately 2000 mammalian promoters, which implies that this protein plays a role in a variety of cellular pro- ...
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The basics of epithelial mesenchymal transition
... lial-mesenchymal transitions (EMTs) represent one important source of these cells. As we discuss here, processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development ...
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View onto the Nephrogenic Zone before Stem Cell Niches Come Apart: Challenge for Smart Drug Delivery
... Metanephric Mesenchymal Cells; EPI: Epithelial Cells; Six2: Sine Oculis Homeobox Homolog2; CITED1: CBP/p300-interacting transactivator1; Bcl2: B-cell Lymphoma2; CM: Cap Mesenchyme; SBA: Soybean Agglutinin; ...
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Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis
... process, these changes were furthermore accompanied by a pronounced actin-cytoskeleton remodeling and morpho- logical change which is regarded as a hallmark feature of EMT [12, 35]. Interestingly, not all classical ...
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Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches
... for example, cytokeratins and E-cadherin would decline, while expressing mesenchymal-specific proteins such as vimentin, fibronectin, and N-Cad increase. Researchers determined the major transcription parameters ...
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Immunology of fibrotic lung disease: managing infections whilst preventing autoimmunity?
... Figure 1 Transition of inflammation to fibrosis in interstitial lung disease. Toxic or infectious antigens delivered via air or blood supply to lung parenchyma represent a danger signal which triggers an inflammatory ...
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Links between cancer stem cells and epithelial– mesenchymal transition
... The epithelial–mesenchymal transition (EMT) has been reported to be an important program that is often activated during the process of cancer invasion and ...of mesenchymal cells have been greatly ...
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ARA55 in Cancers: A Double-Edged Sword
... EMT: Epithelial-To-Mesenchymal Transitions, FA: Focal Adhesion, Hic-5: Hydrogen Peroxide-Inducible Clone 5 protein, MAPK15: Mitogen- Activated Protein Kinase 15, ORF: Open Reading Frame, PCCs: ...
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