epithelial-to-mesenchymal
Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions
... Epithelial-to-mesenchymal transition (EMT) and its reverse process, mesenchymal-to-epithelial transition (MET), play important roles in embryogenesis, stem cell biology, and cancer ...
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Epithelial to mesenchymal transition is associated with rapamycin resistance
... that epithelial-to-mesenchymal transition (EMT) confers rapamycin ...the epithelial marker E-cadherin protein is higher in rapamycin sensitive (RS) cells and mesenchymal breast cancer cell ...
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ZEB1 drives epithelial to mesenchymal transition in lung cancer
... in epithelial-to-mesenchymal transition ...bronchial epithelial cells (HBECs) and determined that EMT and ZEB1 expression are early, critical events in lung cancer ...repressed epithelial ...
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Attenuation of early liver fibrosis by herbal compound “Diwu Yanggan” through modulating the balance between epithelial to mesenchymal transition and mesenchymal to epithelial transition
... of epithelial-to-mesenchymal transi- tion (EMT) in hepatic fibrogenesis as an evolving patho- genetic concept has drawn extensive ...typical epithelial characteristics and acquire me- senchymal ...
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Novel clinical therapeutics targeting the epithelial to mesenchymal transition
... The epithelial to mesenchymal transition (EMT) was first described in the context of being a fundamental component in the differentiation of tissues and organs within the developing embryo ...
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Epithelial to mesenchymal transition and breast cancer
... the epithelial to mesenchymal phenotype, and the reverse ...normal-like epithelial cells undergoing ...the mesenchymal phenotype in primary tumors and metastases may prove to be a difficult ...
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Epithelial to Mesenchymal Transition of Mesothelial Cells in Tuberculous Pleurisy
... whether epithelial to mesenchymal transition (EMT) of mesothelial cells occurs in tuberculous ...from epithelial to mesenchymal cells, with the loss of epithe- lial morphology and reduction in ...
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Mechanisms and drivers of epithelial to mesenchymal transition in COPD
... People with COPD have a six-fold increased risk of developing lung cancer [67, 68]. This risk is independent of their age, gender and current smoking status, which indicates that COPD itself is an independent predictor ...
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β2 adrenergic agonist suppresses eosinophil-induced epithelial-to-mesenchymal transition of bronchial epithelial cells
... of epithelial cells and eosinophils up-regulates the expression of integrins on eosinophils and ICAM-1 and VCAM-1 on epithelial cells, and that inhibition of integrin-mediated cell-contact inhibits EMT of ...
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Contribution of epithelial-mesenchymal transitions to organogenesis and cancer metastasis.
... The epithelial-to-mesenchymal transition (EMT) describes a cellular process during which epithelial cells transition to a mesenchymal cell ...completely epithelial to a fully ...
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Effects of PPARγ ligands on TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells
... To explore potential regulation of EMT in AECII by PPARg ligands, we have used A549 cells as a model of human AECII. A549 cells possess many features of nor- mal AECII cells [29] and have been used in numerous studies ...
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Epithelial Mesenchymal Transition: a double-edged sword
... The epithelial cobble- stone growth pattern is held together by cell adhesion molecules (claudins and ...anchors epithelial cells, through hemidesmosomes, to the ECM and provide their apical-basal ...from ...
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OVOL guides the epithelial-hybrid-mesenchymal transition
... of Epithelial-to-Mesenchymal Transition (EMT) and its ...hybrid epithelial/mesenchymal (E/M) phenotype that has maximum cellular plasticity and allows migration of Circulating Tumor Cells ...
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mAChRs activation induces epithelial-mesenchymal transition on lung epithelial cells
... of epithelial marker expression in A549 cells and concur- rent gains in mesenchymal ...an epithelial to mesenchymal-like phenotype may be oc- curred in lung epithelial cells and ...
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A Computational and Experimental Model of the Epithelial Mesenchymal Transition.
... from epithelial to mesenchymal with the addition of TGF-β, but now, if the concentration of TGF-β was reduced far enough, the cell would be able to revert back to its epithelial state once it crossed ...
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Cellular therapy of corneal epithelial defect by adipose mesenchymal stem cell-derived epithelial progenitors
... The management of severe CE defects is challenging. When medical treatments fail and the defects or ulcer per- sist (for more than 3 weeks), conventional surgical treat- ments become indicated [5]. In severe cases, the ...
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Epithelial mesenchymal transitions and hepatocarcinogenesis
... venous infiltration, and microsatellite formation (14). Hepatoma cell lines also differ somewhat in their endogenous expression of putative EMT regulators, with the greatest expression occurring in lines expressing more ...
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Wnt5a is required for proper epithelial mesenchymal interactions in the uterus
... Wnt genes encode secreted glycoproteins that regulate cell and tissue growth and differentiation (Polakis, 2000) and activate multiple signaling pathways through the frizzled receptors and the cytoplasmic signaling ...
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Clinical significance of epithelial-mesenchymal transition
... of epithelial-mesenchymal transition (EMT), a process where cells change their epithelial towards a mesenchymal phenotype, has gained overwhelming attention especially in the cancer research ...
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The basics of epithelial mesenchymal transition
... lial-mesenchymal transitions (EMTs) represent one important source of these cells. As we discuss here, processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are ...
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