Equilibrative nucleoside transporter
High expression of the human equilibrative nucleoside transporter 1 gene predicts a good response to decitabine in patients with myelodysplastic syndrome
... human equilibrative nucleoside transporter 1; IPSS: international Prognostic Scoring System; LINE1: long interspersed nucleotide elements 1; MDS: myelodysplastic syndrome; OR: overall response; ...
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Persistent Hepatitis C Virus Infection Impairs Ribavirin Antiviral Activity through Clathrin-Mediated Trafficking of Equilibrative Nucleoside Transporter 1
... Ribavirin (RBV) continues to be an important component of interferon-free hepatitis C treatment regimens, as RBV alone does not inhibit hepatitis C virus (HCV) replication effectively; the reason for this ineffectiveness ...
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Ectopic Mineralization of Spinal Tissues in Mice Lacking Equilibrative Nucleoside Transporter 1
... Equilibrative nucleoside transporter 1 (ENT1) regulates the bi-directional transfer of hydrophilic nucleosides, such as adenosine, across the plasma ...
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FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia
... a nucleoside analog that requires membrane transport proteins of the human nucleoside transporters (hNT) gene families SLC28 and SLC29 to be internalized into target ...Concentrative Nucleoside ...
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Uptake of purines in Plasmodium falciparum infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter
... these inhibitors was re-assessed to confirm which trans- porters are blocked and at what concentration. Uptake of sorbitol, a well-known substrate of the NPP [11,23], into infected RBC was almost fully blocked by NPPB. ...
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Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
... hospitalized patients. Therapeutic approaches to prevent and treat AKI are extremely limited. Better understanding of the molecular pathways promoting postischemic reflow could provide new candidate targets for AKI ...
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Modeling interactions between Human Equilibrative Nucleoside Transporter 1 and other factors involved in the response to gemcitabine treatment to predict clinical outcomes in pancreatic ductal adenocarcinoma patients
... Herein we analyzed potential changes in the expression levels of hENT1, DCK, MRP1 and CHOP, as are the main factors involved in the gemcitabine response pathway and they are involved in [r] ...
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Human Equilibrative Nucleoside Transporter Subtype 1: Structure-Function Analysis Using Cysteine Mutagenesis and Thiol Modifying Techniques
... of nucleoside formation is through a series of resourceful enzymatic cascades involving the breakdown of ...these nucleoside pools can have an important impact on their secondary function as signaling ...
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Transient Down-Regulation of Nucleoside Transporter 3 Gene Expression as a Drug Target in Leishmania major Using Antisense RNA Technology
... the Equilibrative Nucleoside Transporter SLC29 family in the human genome database (8, 9) or the ...the transporter classifi- cation database (10). Nucleoside transporters are present ...
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Reduced Ribavirin Antiviral Efficacy via Nucleoside Transporter-Mediated Drug Resistance
... of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most ...
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Gene expression of <em>hENT1</em>, <em>dCK</em>, <em>CDA</em>, <em>dCMPD </em>and <em>topoisomerase </em>IIα as an indicator of chemotherapy response in AML treated with cytarabine and daunorubicin
... human equilibrative nucleoside transporter 1, deoxycytidine kinase, cytidine deaminase (CDA), deoxycytidine monophosphate deaminase (dCMPD) and topoisomerase IIα ...
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Investigating The Mechanism Of Ectopic Mineralization In A Mouse Model Of Diffuse Idiopathic Skeletal Hyperostosis (DISH)
... Warraich S, Bone DB, Quinonez D, Ii H, Choi DS, Holdsworth DW, Drangova M, Dixon SJ, Seguin CA, & Hammond JR (2013) Loss of equilibrative nucleoside transporter 1 in mice leads to [r] ...
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ENT1 and ENT1 mice during both normoxic and hypoxic conditions. Gene expression was
... Adenosine is important in the regulation of vascular tone and the Equilibrative Nucleoside Transporter 1 (ENT1) is a regulator of adenosine concentrations. Thus, changes in ENT1 expression and ...
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Ormanns, Steffen (2018): Molekulare Dysregulationen und ihre Biomarker im Pankreaskarzinom. Habilitationsschrift, LMU München: Medizinische Fakultät
... Obgleich die große Mehrheit der PDAC aktivierende KRAS-Gen Mutationen aufweist, was auf eine konstitutive Aktivierung des MAPK-Signalweges schließen lässt, zeigen wir im fortgeschrittenen Pankreaskarzinom eine heterogene ...
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Human Immunodeficiency Virus Type 1: Resistance to Nucleoside Analogues and Replicative Capacity in Primary Human Macrophages
... other nucleoside analogues and also markedly higher in macrophages than in tumor cells ...of nucleoside analogues, including 3TC, in patients with multiple drug resistance and stable plasma viral load ...
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The influence of HAART on the efficacy and safety of pegylated interferon and ribavirin therapy for the treatment of chronic HCV infection in HIV-positive individuals
... a nucleoside free HAART to change to or start a nucleoside free HAART (withdrawal of consent, n = 8) or protocol violation and proceeding with a nucleoside containing HAART despite being randomized ...
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CSGID solves structures and identifies phenotypes for five enzymes in Toxoplasma gondii
... putative nucleoside diphosphate kinase (TgNDK) (residues 1– 155), ribulose phosphate 3-epimerase (TgRPE) (residues 1– 230), a putative ribose 5-phosphate isomerase (TgRPI) (residues 1–259), and a putative ...
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Carnitine metabolism to trimethylamine by an unusual Rieske type oxygenase from human microbiota
... Annotation choline/carnitine/betaine transport conserved hypothetical protein putative transporter putative transporter putative transporter betaine/choline/glycine transporter betaine/c[r] ...
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Non-Hepatic Adverse Effects of Antiretroviral Therapy for HIV Treatment and Care
... Nucleoside Reverse Transcriptase Inhibitors: NRTIs are the backbone of ART and are majorly associated with lactic acidosis and lipodystrophy [14,15]. Lactic acidosis manifests with fatigue, nausea and vomiting, ...
6
HIV-1 mutational pathways under multidrug therapy
... to nucleoside (NRTI) and non-nucleoside (NNRTI) reverse transcriptase inhibitors (as listed in the 2008 International AIDS Society report), or which were mutant at therapy start in 5% or more of the ...
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