ErbB Receptors
ErbB Receptors and ErbB Targeted Therapies in Endometrial Cancer
... four receptors (EGFR, ErbB-2, ErbB-3 and ErbB-4) and numerous ...of ErbB receptors (es- pecially EGFR and ErbB-2) as targets for cancer therapy has been investigated for ...
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ErbB receptors: from oncogenes to targeted cancer therapies
... ErbB receptors and their ligands. All four members of the ErbB receptor family share high homology in the extracellular domain and the kinase ...
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Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models
... and ErbB receptors as targets, non-small cell lung cancer cell lines have been shown to respond better to combinations targeting both, compared to individual treatments ...and ErbB receptors ...
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Synergistic antitumor activity of histone deacetylase inhibitors and anti-ErbB3 antibody in NSCLC primary cultures via modulation of ErbB receptors expression
... Interestingly, we have recently demonstrated that vorinostat can improve the therapeutic efficacy of EGFR-TKIs in NSCLC models, including O11 cells, by a mechanism related to increased oxidative stress and a consequent ...
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Mechanisms of resistance to ErbB targeted cancer therapeutics
... The ErbB receptors, such as EGFR, have been intensely pursued as targets for cancer ...to ErbB-targeted therapies experience tumor recur- rence and become refractory to ...to ErbB-targeted ...
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The importance of ERBB receptor tyrosine kinase signaling in colorectal cancer : implications for EGFR-targeted therapies
... by ERBB receptors stems from their interdependence and ...four ERBB members, ERBB2 and ERBB3 are functionally non-autonomous: ERBB2 does not have a recognized ligand, while ERBB3 lacks intrinsic ...
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Spinal nerve injury causes upregulation of ErbB2 and ErbB3 receptors in rat dorsal root ganglia
... of ErbB receptors, a well- known growth factor in somatic cells, reportedly follows peripheral nerve injury in the spinal dorsal horn; however, it remains unknown whether the expression of these ...
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ERBB signaling in CTCs of ovarian cancer and glioblastoma
... of ERBB receptors on CTC formation of ovarian cancer and glioblastoma is not well ...of ERBB family receptors on resistance to anoikis and CTC formation in ovarian cancer and ...capturing ...
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Unveiling the Molecular Mechanisms Regulating the Activation of the ErbB Family Receptors at Atomic Resolution through Molecular Modeling and Simulations
... which ErbB receptors activate and regulate signaling has not been fully ...of ErbB signaling in several pathologies such as cancer, psoriasis, atherosclerosis, impaired cardiac development, and ...
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The ERBB STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease
... the ERBB receptors (29/69; 42%) including lapatinib, erlotinib, and sapitinib (Figure 1B, Table ...human ERBB family has four members (EGFR, ERBB2, ERBB3, and ERBB4) (Hynes and Lane, 2005), of which ...
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Regulation of ErbB2 localization and function in breast cancer cells by ERM proteins
... [21]. ErbB dimerization leads to the activation of Akt- and Erk-dependent signal transduction ...Thus, ErbB receptors have become attractive targets for anti cancer therapies and several ErbB ...
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A global microRNA screen identifies regulators of the ErbB receptor signaling network
... by ErbB receptors include the mitogen activated protein kinase (MAPK) and PI3K pathways, which stimulate cellular responses such as survival, proliferation, and ...to ErbB receptors induces ...
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Functional interaction between mouse erbB3 and wild type rat c neu in transgenic mouse mammary tumor cells
... of erbB receptors or mutational events thereof have been implicated in diverse types of human cancers ...other erbB family receptors with bound ligand ...
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Intracellular signaling pathways of ErbB2/HER 2 and family members
... the ErbB receptors, including the Drosophila and ...single ErbB receptor are known to impinge on this signaling pathway, via various signaling routes, prompting the question of how signaling ...
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Increased expression of neuregulin 1 in the urothelium of rat bladder with partial bladder outlet obstruction
... NRG1/ErbB receptors may exert a func- tional role via receptors located in the urothelium as a result of muscarinic receptor activation and NRG1/ErbB may be associated with detrusor smooth ...
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G PROTEIN COUPLED RECEPTORS A POTENTIAL NEW DRUG TARGET TO COMBAT DIABETIC SYNDROME: AN OVERVIEW
... Structure of G-Protein Coupled Receptors: GPCRs are integral membrane proteins that possess seven membrane-spanning domains or transmembrane helices (figure 1). The extracellular parts of the receptor can be ...
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Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice
... The key to developing CSC/TIC inhibitors is to under- stand the underlying mechanisms that result in selective inhibition of CSC/TIC populations, as demonstrated by buformin in our models of erbB-2-overexpressing ...
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The v-erbB oncogene confers enhanced cellular susceptibility to reovirus infection.
... containing EGFR or its homologs become dependent on ty- rosine kinase activation for efficient translation of their mRNAs, and any acute disruption of this early activation may adversely affect subsequent protein ...
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016_2009.pdf
... 5-HT receptors to defi ned tissues has also had some success to modulate tissue function (Kerr et ...these receptors can be used to produce both short-term and long-term modulation of activity, and only ...
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MW ASSISTED SYNTHESIS AND BIOLOGICAL PREDICTION STUDY OF SOME NEW PYRAZOLE 4 CARBONITRILE DERIVATIVES USING MALONONITRILE
... Activity Complement factor D inhibitor ErbB-1 antagonist Aspulvinonedimethylallyltransferase inhibitor Antipsoriatic Thiol protease inhibitor Monodehydroascorbate reductase NADH inhibito[r] ...
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