ERCC2 gene
Original Article Impact of single nucleotide polymorphisms in ERCC2 gene and their interaction with smoking on esophageal squamous cell carcinoma risk in Chinese Han population
... the ERCC2 gene according to the following standards: 1) SNP, which have been reported associations with ESCC risk; 2) SNP, the minor allele frequency (MAF) of which was more than ...of ERCC2 ...
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Original Article Prognostic value of ERCC1 and ERCC2 gene polymorphisms in patients with gastric cancer receiving platinum-based chemotherapy
... two gene polymorphisms are a part of an endonuclease ...and ERCC2 is in- volved in the damage unwinding process [5, ...and ERCC2 gene polymorphisms and development of gastric cancer, but the ...
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Original Article Association between XRCC1 and ERCC2 gene polymorphisms and development of osteosarcoma
... XRCC1 gene (Arg194Trp, rs1799782; Arg280His rs25489; Arg399Gln rs25487) and one SNP in ERCC2 gene (Lys751Gln rs13181) with the susceptibility to ...and ERCC2 Lys751Gln polymorphisms were ...
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Investigating the Distribution of ERCC2 (rs13181) Gene Polymorphism in Gastric Cancer Patients in Mazandaran: A Case-control Study
... The genotype was determined by polymerase chain reaction enzymatic digestion by PCR- RFLP. Amplification was performed using a specific primer pair and a piece of 267 bp. Primers were designed using Gene Runner ...
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Original Article Role of ERCC1 and ERCC2 genetic polymorphisms in the sensitivity of esophageal squamous cell carcinoma to radiochemotherapy in a Chinese population
... repair gene excision repair cross-complementing group 1 (ERCC1) plays an important role in nucleotide excision repair (NER), and is associated with repairing platinum-induced interstrand and intrastrand DNA ...
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Frequent retrotransposition of endogenous genes in ERCC2-deficient cells derived from a patient with xeroderma pigmentosum
... One of the two mutations was a single-nucleotide non- synonymous substitution at GRCh38 position 45,352,351 (GRCh37 position 45,855,609) on chromosome 19. This nonsynonymous mutation rs758439420 (C to T) pre- dicts a ...
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ERCC2, ERCC1 polymorphisms and haplotypes, cooking oil fume and lung adenocarcinoma risk in Chinese non-smoking females
... and ERCC2) are the important DNA repair genes, playing critical roles in nucleotide excision repair (NER) pathway which is the most important system to repair a wide variety of structur- ally DNA lesions, ...
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Association between common polymorphisms in <em>ERCC </em>gene and prognosis of osteosarcoma in patients treated with chemotherapy: a meta-analysis
... ERCC1 gene (rs11615, rs2298881, and rs3212986), ERCC2 gene (rs13181 and rs1799793), ERCC4 gene (rs1800067), or ERCC5 gene (rs2296147 and rs1047768) with the prognosis for patients with ...
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Original Article Genetic variability of DNA repair mechanisms influences chemotherapy outcome of gastric cancer
... ERCC1-ERCC2 gene polymorphisms in the chemotherapy response and clinic outcome of gastric ...and ERCC2 rs3212986 were conducted by polymerase chain reaction restriction fragment length poly- morphism ...
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Genetic polymorphisms in ERCC1 and ERCC2 genes are associated with response to chemotherapy in osteosarcoma patients among Chinese population: a meta analysis
... ERCC2 gene possesses more than 500 SNPs, among which rs13181 and rs1799793 are the two common polymor- phisms that can alter the amino acid sequence in the ERCC2 gene ...The ERCC2 ...
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Gastric Cancer Risk and XPD/ERCC2 SNPS (LYS751GLN, ASP312ASN) Gene Polymorphism—An Experimental Study in Kashmir Valley of India
... in ERCC2 gene in the risk of GC in the Kashmiri population of ...the ERCC2 Lys751Gln and Asp312Asn polymorphisms, particularly the Lys751Gln polymorphism in the Kashmiri population of J&K ...of ...
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Original Article Association between intronic polymorphisms of XRCC1 ERCC2 and LIG1 genes and risk of esophageal squamous cell carcinoma in a Chinese Han population
... ERCC2 gene encoded excision repair cross- complementation group 2 protein is also kno- wn as xeroderma pigmentosum complementa- ry group D ...(XPD). ERCC2 plays important roles in NER pathways, a ...
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Original Article Association of single nucleotide polymorphisms of DNA repair genes in NER pathway and susceptibility to pancreatic cancer
... The ERCC2 protein, encoded by the gene locat- ed at chromosome ...the ERCC2 gene are thought to reduce the helicase activity, resulting in a lower DNA repair capacity of NER pathway and ...
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Original Article Association between ERCC1 rs3212986 and ERCC2 rs13181 gene polymorphisms in NER pathway and the risk of bladder cancer in a Chinese population
... The ERCC2 pro- tein is located at chromosome ...the ERCC2 gene have a role in decreasing the helicase activity, and causing in a lower DNA repair capacity of NER pathway as well as influencing cancer ...
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Original Article ERCC2 Lys751Gln genetic variation is associated with the susceptibility to gastric cancer in a Chinese population
... crosslinks. ERCC2 gene products are important rate-limiting enzymes during the nucleotide excision repair process, which is involved in maintaining genomic integrity by removing DNA interstrand crosslinks ...
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Towards gene network estimation with structure learning
... complex. Gene interactions are studied through gene network. Gene network is a group of coordinately expressed genes controlling a particular function of an ...reconstructing gene networks, we ...
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Genetic variants in the nucleotide excision repair pathway genes and gastric cancer susceptibility in a southern Chinese population
... Methods: Here, we systematically analyzed the associations between nine polymorphisms in four key genes (XPA, ERCC1, ERCC2, and ERCC4) in the nucleotide excision repair pathway and gastric cancer risk in a Chinese ...
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Diagnostic and prognostic values of the mRNA expression of excision repair cross-complementation enzymes in hepatitis B virus-related hepatocellular carcinoma
... Background: The current study aims at using the whole genome expression profile chips for systematically investigating the diagnostic and prognostic values of excision repair cross-com- plementation (ERCC) genes in ...
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Nucleotide excision repair pathway gene polymorphisms are linked to breast cancer risk in a Chinese population
... NER repairs damage introduced by ultraviolet (UV) radiation, products of organic combustion, intrastrand DNA cross-links, heavy metals, and oxidative stress. Several proteins, including ERCC1, XPA, XPB/ ERCC3, XPC, ...
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From pattern to gene, from gene to pattern
... pair-rule gene mutants in Drosophila was wholly unexpected because it revealed that the establishment of the overt segmental periodicity of the larva proceeded through an intermediate, morphologically invis- ible, ...
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