ERK/MAPK pathway
Essential role of the ERK/MAPK pathway in blood placental barrier formation
... the ERK/MAPK pathway might be involved in the control of Cdx2 expression via FGF signaling and in the proliferation of the progenitors that sustain the growth of the labyrinth and the production of ...
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Modulation of Gq-Rho Signaling by the ERK MAPK Pathway Controls Locomotion in Caenorhabditis elegans
... Gq-Rho pathway. Through epistasis experiments, we found that the core ERK MAPK cascade is required for Gq-Rho regulation of locomotion, but that the canonical ERK activator LET-60/Ras may not ...
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Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling
... enhances ERK/MAPK signal ...and ERK phosphorylation ...of ERK/MAPK pathway (PD98059) decreased the MMP-2 mRNA and protein expression ...
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Visna Virus-Induced Activation of MAPK Is Required for Virus Replication and Correlates with Virus-Induced Neuropathology
... (MAPKs), ERK-1/2, in primary cells susceptible to visna virus and report that virus infection induces and sustains activation of the ERK/MAPK ...the ERK/MAPK pathway, abolishes ...
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Requirement for Map2k1 (Mek1) in extra embryonic ectoderm during placentogenesis
... Multiple MAPK pathways have been described in vertebrates, which include the extracellular signal-regulated kinase (ERK), the p38 kinase and the Jun NH2-terminal kinase (Cano and Mahadevan, 1995; Seger and ...
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Decreased MALL expression negatively impacts colorectal cancer patient survival
... of ERK possibly through ...the ERK MAPK pathway, which is consistent with previous studies showing that cell adhesion, angiogenesis, invasion, and metastasis in colorectal cancer could be ...
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Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38 MAPK signaling pathways
... of ERK and p38 is critical in governing melanogenesis ...of MAPK pathway start to ...of ERK [28], whereas inactivation of MEK1/2 could sti- mulate a -MSH-induced p38 MAPK activity ...
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LncRNA SLCO4A1-AS1 predicts poor prognosis and promotes proliferation and metastasis via the EGFR/MAPK pathway in colorectal cancer
... Proteintech), ERK (1:2000, Abcam), P-ERK (1:2000, Abcam), MAP3K1 (1:700, Proteintech), P-MAP3K1 (1:1000, Proteintech), β-actin (1:700, Proteintech), incubate for 2 hours at room temperature with anti-rabbit ...
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A Review of the Molecular Pathways of Oncogenic HPV and Targeted the Rapies in Carcinoma of the Uterine Cervix
... d. ERK/Mitogen Activated Protein Kinase (MAPK) pathway also known as RAF/MEK pathway lies downstream of several growth factors such as Epidermal Growth Factor (EGF) which when activated ...
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ERK Is a Critical Regulator of JC Polyomavirus Infection
... transduction pathway, including hepatitis C virus, HIV-1, influenza virus (IAV), severe acute respiratory syn- drome coronavirus (SARS-CoV), Kaposi’s sarcoma-associated herpesvirus (KSHV), and Epstein-Barr virus ...
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PubMedCentral-PMC5566864.pdf
... the ERK: A2a ...express ERK in A2a-Cre mice. These findings argue that the loss of ERK activity specifically in D2R-MSNs before or during the “critical period” of network formation (Tepper et ...in ...
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Dynamic regulation of VEGF inducible genes by an ERK/ERG/p300 transcriptional network
... Fig. 5. A network of VEGF-inducible genes are ERK/ERG/p300 dependent. (A) Hierarchical clustering of microarray analysis identified a group of 30 VEGF- inducible genes that are suppressed in ERG knockdown cells, ...
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MicroRNA 543 suppresses breast cancer cell proliferation, blocks cell cycle and induces cell apoptosis via direct targeting of ERK/MAPK
... of MAPK/ERK signal ...of ERK pathway in S6 ribosome kinase, was activated and phosphorylated via ERK1/2, responding to growth factors and chemokines that were implicated with essential cell ...
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A constitutive active MAPK/ERK pathway due to BRAF V600E positively regulates AHR pathway in PTC
... the MAPK/ERK signaling is able to upregulate the AHR pathway in these tumors, suggesting that targeting the AHR pathway might have potential therapeutic benefit in their clinical ...
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Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity
... positive and negative regulation of a wide range of target proteins (not all shown). Cyclin D1 (CCND1) and MDM2 are up-regulated directly or indirectly, resulting in a positive stimulus via the RB or p53 pathways, ...
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Original Article Effects of MAPK/ERK pathway on learning and memory in sleep deprivation rats
... in MAPK/ERK signaling pathway and learning/memory in sleep deprivation rats, and explore the mechanism of memory impairment in those ...detect MAPK/ERK signaling pathway- related ...
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Original Article p38 regulates mRNA stability of cytokines stimulated by Zymosan A
... SB202190, ERK inhibitor PD98059, and JNK inhibitor SP600125, to block the targeted pro- tein kinase, and then were stimulated with Zymosan A (100 ng/mL) and LPS (10 ng/mL) for 60 ...of MAPK sig- naling ...
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miR-144/451 cluster plays an oncogenic role in esophageal cancer by inhibiting cell invasion
... Results: Overexpression of miR-144-3p promoted early apoptosis of ECa9706 and inhibited cell migration, cell inva- sion and cell proliferation. miR-144-5p and miR-451a inhibited cell proliferation, at the same time, ...
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Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone refractory prostate cancer in a preclinical mouse model
... AKT/mTOR pathway activation is associated with human prostate cancer progression and correlated with activation of ERK ...signaling pathway in human normal and primary prostate cancer ...
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<p>CCNY Accelerates Cylcin E Expression to Regulate the Proliferation of Laryngeal Carcinoma Cells via MEK/ERK Signaling Pathway</p>
... signaling pathway was regulated by the expression of CCNY in Hep2 cells. The MAPK signaling pathway plays a critical role in many important cellular pro- ...MEK/ERK pathway is one of ...
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