ESCRT-0
Ubpy controls the stability of the ESCRT 0 subunit Hrs in development
... by ESCRT complexes, and are sorted into invaginating multivesicular bodies ...2009). ESCRT-0 is composed of heterodimers of two subunits: Hrs and ...allows ESCRT-0 to initiate endosomal ...
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ESCRT-0 Component Hrs Promotes Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus in Human Dermal Microvascular Endothelial Cells
... complexes, ESCRT-0, -I, -II, and -III, which sequentially assemble on the endosomal ...The ESCRT-0 component Hrs (hepatocyte growth factor [HGF]-regulated tyrosine kinase substrate) acts ...
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A complex network of interactions between mitotic kinases, phosphatases and ESCRT proteins regulates septation and membrane trafficking in S. pombe
... that ESCRT genes are required for cytokinesis and cell separation in fission ...individual ESCRT gene deletions, and a deletion mutant of clp1 (clp1D) and temperature sensitive mutants of plo1 and ark1 ...
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The Structural Biology of HIV Budding and Maturation
... the ESCRT pathway in MVB biogenesis and viral budding are also likely driven by a "dome" ...to ESCRT-0, -I, or –II, but CdvA performs the same function of recruiting ESCRT-III to the ...
163
Endosomal trafficking of yeast membrane proteins
... in ESCRT-0, -I and -II complexes allow ESCRTs to act as receptors at the MVB for ubiquitinated cargoes that are targeted for degradation [9] ...The ESCRT accessory factor Bro1, which recruits ...
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The Candida albicans ESCRT Pathway Makes Rim101-Dependent and -Independent Contributions to Pathogenesis
... The ESCRT pathway also activates the Rim101 transcription factor, which governs expression of genes required for ...the ESCRT pathway plays a Rim101-independent role(s) in ...each ESCRT complex and ...
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Role of the ESCRT Complexes in Telomere Biology
... upregulation, ESCRT factors could serve as new targets to hinder telomerase function in tumor ...as ESCRT factors are essential to mammals and disruption of them bears the poten- tial for oncogenicity, ...
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The Ancient Small GTPase Rab21 Functions in Intermediate Endocytic Steps in Trypanosomes
... endosomes, ESCRT com- ponents recognize ubiquitinated cargo and sort it into intralume- nal vesicles (ILVs) giving the characteristic appearance to ...of ESCRT-0. ESCRT-0 recruits ...
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Human Cytomegalovirus Exploits ESCRT Machinery in the Process of Virion Maturation
... of ESCRT machinery and are be- lieved to use an alternative virus-intrinsic pathway ...the ESCRT machinery consists of five multiprotein complexes (ESCRT-0, -I, -II, and -III and Vps4-Vta1) ...
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Interaction Maps of the Saccharomyces cerevisiae ESCRT-III Protein Snf7
... The ESCRT-III complex appears to be crucial for the final stage of ILV formation, the membrane abscission step (5, ...Yeast ESCRT-III is composed of four proteins (Snf7, Vps20, Vps2/ Did4, and Vps24) (7) ...
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Nonenvelopment Role for the ESCRT-III Complex during Human Cytomegalovirus Infection
... the ESCRT complexes are sequentially recruited to promote cargo clustering and vesicle ...clude ESCRT-0, ESCRT-I, ESCRT-II, ESCRT-III, and the VPS4 AAA ...these ESCRT ...
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Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation
... Pathways of ubiquitin-directed protein degradation include a deubiquitination step for ubiquitin recycling. Of the 17 deu- biquitinating enzymes present in yeast, Doa4 is the only one that is functionally linked to the ...
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Distinct Roles of Cellular ESCRT-I and ESCRT-III Proteins in Efficient Entry and Egress of Budded Virions of Autographa californica Multiple Nucleopolyhedrovirus
... designated ESCRT-0, I, II, III, and the AAA ATPase Vps4, as well as some ESCRT-associated proteins, such as Alix (1, ...2). ESCRT-0 is required for selectively sorting ubiquitinated ...
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Pre-ESCRT Step of Endocytosis Pathway Regulates Parkinson's Disease Protein alpha-Synuclein
... Our next goal was to examine how α-synuclein properties changed in vps34Δ. In support of our hypothesis, both WT and E46K α-synuclein had altered localization at 48 hours but not 24 hours. In vps34Δ, α -Synuclein was ...
8
Aspergillus nidulans Ambient pH Signaling Does Not Require Endocytosis
... of ESCRT complexes, which have a key role in multivesicular body (MVB) sorting in endo- somes, led to a model in which the pH-sensing module and the ESCRT-associated proteins would be spatially separated, ...
9
Evidence for B-0 ->pi(0)pi(0)
... In order to obtain the branching fraction, we divide the signal yield by the reconstruction efficiency, measured from MC to be 9.9%, and by the number of BB pairs. The trigger efficiency is not corrected since it is ...
5
Ubiquitin conjugation to Gag is essential for ESCRT mediated HIV 1 budding
... The ESCRT-I component TSG101 binds directly to PTAP motifs within the HIV-1 Gag protein and eliminating the PTAP motif or the ability of TSG101 to bind Gag reduces viral release by ...other ESCRT-I ...
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BCI-1. ) = 0 BCI-2. = 0 BCI-3. = 0 BCI-4. = 0 and = 0 implies that BCI-5. 0= 0, for all
... Let 𝑥𝑥 ∗ 𝑦𝑦 ∈ 𝐵𝐵 and 𝑦𝑦 ∈ 𝐵𝐵 . Then there are 𝐼𝐼 1 , 𝐼𝐼 2 ∈ 𝑆𝑆 0 such that 𝑥𝑥 ∗ 𝑦𝑦 ∈ 𝐼𝐼 1 and 𝑦𝑦 ∈ 𝐼𝐼 2 . We can suppose 𝐼𝐼 2 ⊆ 𝐼𝐼 1 without loss of any generality. Thus 𝑥𝑥 ∗ 𝑦𝑦 ∈ 𝐼𝐼 1 , 𝑦𝑦 ∈ 𝐼𝐼 1 and 𝑦𝑦 ∈ 𝐼𝐼 1 . ...
5
The C-Terminal Half of TSG101 Blocks Rous Sarcoma Virus Budding and Sequesters Gag into Unique Nonendosomal Structures
... all ESCRT proteins associate with TICS. TSG101 is a member of the ESCRT complex and interacts with all other members of this complex either directly or ...the ESCRT complex is recruited to the TICS ...
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