Estrogen Receptor (ER)
The Role of Estrogen Receptor-a and Estrogen Receptor-b in the Hyperluteinized Mouse Ovary
... Chapter 3. Characterization of the hypothalamic-pituitary-gonadal (HPG) axis in estrogen receptor null mice reveals hypergonadism and endocrine sex-reversal in females lacking ER a but not ER b . Chapter 3 ...
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Growth factor activation of the estrogen receptor in vascular cells occurs via a mitogen activated protein kinase independent pathway
... demonstrates estrogen-independent activation of the estrogen receptor in vascular cells and shows further that this pathway in vascular cells is independent of MAP kinase and thus distinct from that ...
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Characterization and prognosis of estrogen receptor positive/progesterone receptor negative male breast cancer: a population based study
... for estrogen receptor (ER) and progesterone receptor (PR) markers has been recommended for all newly diagnosed breast cancer patients by the College of American Pathologists and American Society of ...
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Original Article The expression of transcription factor BORIS and its association with the estrogen receptor beta (ER-β) in cervical carcinogenesis
... main estrogen receptor subtype expressed in the cervical epithelium and suggest that ER-β is the predominant estrogen receptor subtype ex- pressed in the neoplastic cervical epithelium, and ...
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Centromere protein A, an essential centromere protein, is a prognostic marker for relapse in estrogen receptor positive breast cancer
... Consistent with our results, Hu, et al. recently found that Holliday Junction Recognition Protein (HJURP), which has been proposed to act as a CENP-A-specific chaperone responsible for the deposition of CENP-A at ...
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Estrogen receptor transcription and transactivation Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer
... two estrogen receptor subtypes, ER α and ER β , that have differing affinities and responsiveness to various SERMs, and differing tissue distribution and effectiveness at different gene regulatory ...
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BRCA1 And Estrogen/Estrogen Receptor In Breast Cancer: Where They Interact?
... in estrogen responsive tissues such as breast and ...and estrogen receptor) signaling synergistically regulate the mammary epithelial cell proliferation and ...
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Effects of selective estrogen receptor agonists on estrogen receptor expression in the uterus of ovariectomized rats
... with estrogen receptor (ER) selective agonists on ERα, ERβ and G-protein cou- pled estrogen receptor-1 (GPER) expression in the uterus of ovariectomized ...the estrogen receptors in the ...
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The Transactivating Function 2 (AF 2) of Estrogen Receptor (ER) α Is Indispensable for ERα Mediated Physiological Responses and AF 1 Activity
... the estrogen receptor (ER) is a key regulator of those ...several estrogen-mediated physiological responses in the AF2ERKI ...discern estrogen physiological functions which involve ...
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Farnesyl transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF 7 cell growth through estrogen receptor dependent and independent pathways
... hormone receptor dependent (estrogen receptor (ER)-mediated with two receptor subtypes, ER α and ER β ) and independent (non-ER-mediated) mechanisms ...
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Beta Lactam Estrogen Receptor Antagonists and a Dual Targeting Estrogen Receptor/Tubulin Ligand
... Compound 20 was inactive in the agonist mode but active in the antagonist mode, confirming that β-lactam 20 is acting as an ERα antagonist. This is not unprecedented, as both 1,1,2-tris(4-hydroxyphenyl)alkenes and ...
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Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype
... of estrogen receptor and progesterone receptor mRNA expression in breast ...B: Estrogen receptor and progesterone receptor mRNA expression in GEM ...
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Estrogen Receptor Antagonists Are Anti Cryptococcal Agents That Directly Bind EF Hand Proteins and Synergize with Fluconazole In Vivo
... Previously approved drugs with activities other than that for which they were designed can be valuable scaffolds for further optimization. This approach to new lead identification has been called selective optimization ...
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The therapeutic target of estrogen receptor alpha36 in estrogen dependent tumors
... during estrogen signaling [34]. Interestingly, low concentration of estrogen or certain anti-estrogens like tamoxifen are shown to stimulate cell proliferation by eliciting mitogenic signaling pathway, ...
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Estrogen receptor transcription and transactivation Estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action
... mammals. Estrogen is primarily known for its role in the development and functioning of the female reproductive ...for estrogen in male fertility, bone, the circulatory system and immune system have been ...
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Lead Optimization of Benzoxepin Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype Specific ER alpha and ER beta Activity
... pure estrogen antagonist 5, a known SERD, downregulates the expression of ERα and was used as a positive ...the estrogen-signaling process and thus inducing proliferation arrest and apoptosis of ...
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Estrogen receptor transcription and transactivation Basic aspects of estrogen action
... of receptor specific anti- bodies, both ERα and ERβ were expressed in the normal rat mammary gland, but the presence and cellular distrib- ution of the two receptors was distinct [51 • ...
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Tamoxifen may prevent both ER+ and ER breast cancers and select for ER carcinogenesis: an alternative hypothesis
... the estrogen receptor (ER) status of the first breast primary from long term follow-up of the 5,513 patients from NSABP studies B-18, B-22, and B25 is shown in Table ...
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HER2 and ESR1 mRNA expression levels and response to neoadjuvant trastuzumab plus chemotherapy in patients with primary breast cancer
... factor receptor 2 (HER2) is the prototype of a predictive biomarker for targeted treatment ...the estrogen receptor (ER) and the HER2 pathway has been suggested based on cell culture and animal ...
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Kinase mediated regulation of common transcription factors accounts for the bone protective effects of sex steroids
... the estrogen receptor (ER) or andro- gen receptor (AR), which does not affect classical transcription, reverses bone loss in ovariectomized females or orchidectomized males without affecting the ...
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