Estrogen receptor: estrogen
The Transactivating Function 2 (AF 2) of Estrogen Receptor (ER) α Is Indispensable for ERα Mediated Physiological Responses and AF 1 Activity
... Various estrogen receptor antagonists and selective estrogen receptor modulators (SERMs) have been de- veloped in pharmaceutical research by analyzing deriva- tives of certain estrogenic ...
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Growth factor activation of the estrogen receptor in vascular cells occurs via a mitogen activated protein kinase independent pathway
... classical estrogen receptor ER a mediates many of the known cardiovascular effects of estrogen and is expressed in male and female vascular ...cells. Estrogen-independent acti- vation of ER a ...
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BRCA1 And Estrogen/Estrogen Receptor In Breast Cancer: Where They Interact?
... in estrogen responsive tissues such as breast and ...and estrogen receptor) signaling synergistically regulate the mammary epithelial cell proliferation and ...
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Original Article The expression of transcription factor BORIS and its association with the estrogen receptor beta (ER-β) in cervical carcinogenesis
... main estrogen receptor subtype expressed in the cervical epithelium and suggest that ER-β is the predominant estrogen receptor subtype ex- pressed in the neoplastic cervical epithelium, and ...
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Characterization and prognosis of estrogen receptor positive/progesterone receptor negative male breast cancer: a population based study
... for estrogen receptor (ER) and progesterone receptor (PR) markers has been recommended for all newly diagnosed breast cancer patients by the College of American Pathologists and American Society of ...
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Estrogen Receptor Antagonists Are Anti Cryptococcal Agents That Directly Bind EF Hand Proteins and Synergize with Fluconazole In Vivo
... Previously approved drugs with activities other than that for which they were designed can be valuable scaffolds for further optimization. This approach to new lead identification has been called selective optimization ...
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Estrogen receptor transcription and transactivation Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer
... the estrogen receptor regulates transcription Although the DNA binding domains of ERα and ERβ are nearly identical, there is considerable documentation that these receptor subtypes differ markedly in ...
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The Role of Estrogen Receptor-a and Estrogen Receptor-b in the Hyperluteinized Mouse Ovary
... Chapter 3. Characterization of the hypothalamic-pituitary-gonadal (HPG) axis in estrogen receptor null mice reveals hypergonadism and endocrine sex-reversal in females lacking ER a but not ER b . Chapter 3 ...
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Effects of selective estrogen receptor agonists on estrogen receptor expression in the uterus of ovariectomized rats
... with estrogen receptor (ER) selective agonists on ERα, ERβ and G-protein cou- pled estrogen receptor-1 (GPER) expression in the uterus of ovariectomized ...the estrogen receptors in the ...
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The therapeutic target of estrogen receptor alpha36 in estrogen dependent tumors
... during estrogen signaling [34]. Interestingly, low concentration of estrogen or certain anti-estrogens like tamoxifen are shown to stimulate cell proliferation by eliciting mitogenic signaling pathway, ...
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Farnesyl transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF 7 cell growth through estrogen receptor dependent and independent pathways
... blots of MCF-7 cells incubated with the three 'anti-estrogens'. As a control, untreated cells exhibited complete prenylation of HDJ2 (P, lane 1), while treatment with R115,777 (1 nM) resulted in an accumulation of ...
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Estrogen receptor transcription and transactivation Estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action
... Clinical as well as experimental data imply a role for estro- gen as well as other endocrine factors in maintaining bone mass. For example, menopause or castration increases the rate of osteoporosis progression in women ...
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Lead Optimization of Benzoxepin Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype Specific ER alpha and ER beta Activity
... pure estrogen antagonist 5, a known SERD, downregulates the expression of ERα and was used as a positive ...the estrogen-signaling process and thus inducing proliferation arrest and apoptosis of ...
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Estrogen receptor transcription and transactivation Basic aspects of estrogen action
... of receptor specific anti- bodies, both ERα and ERβ were expressed in the normal rat mammary gland, but the presence and cellular distrib- ution of the two receptors was distinct [51 • ...
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Expression of Molecular Biomarkers in Primary Breast Tumors Implanted into a Surrogate Host: Increased Levels of Cyclins Correlate with Tumor Progression
... tion between the levels of estrogen receptor pro-.. To) are illustrated from To tumor 118, which were undetectable for cyclins D 1 and D3, and undetectable for estrogen receptor; section[r] ...
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Comparative study of ER status in premenopausal and postmenopausal women with carcinoma breast
... The decision of whether to use adjuvant tamoxifen for patients with DCIS should be made on an individual basis. The use of tamoxifen has been associated with vasomotor symptoms, deep vein thrombosis, pulmonary embolism ...
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Tamoxifen may prevent both ER+ and ER breast cancers and select for ER carcinogenesis: an alternative hypothesis
... the estrogen receptor (ER) status of the first breast primary from long term follow-up of the 5,513 patients from NSABP studies B-18, B-22, and B25 is shown in Table ...
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Oxidative stress and breast cancer biomarkers : the case of the cytochrome P450 2E1
... The estrogen receptor positive MCF-7 and the triple negative MDA- MB-231 breast cancer cells were used as experimental system to estimate ROS generation in these cells overexpressing CYP2E1 and treated with ...
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A pilot study of the immunogenicity of a 9-peptide breast cancer vaccine plus poly-ICLC in early stage breast cancer
... in estrogen receptor positive patients was shown to be feasible and ...the estrogen receptor posi- tive patients were able to generate T cells response to pep- tide ...
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Ospemifene for the treatment of dyspareunia associated with vulvar and vaginal atrophy: potential benefits in bone and breast
... In another chemically-induced estrogen receptor + breast cancer mouse model, Sencar mice were used to induce breast cancer with dimethylbenzantharene. In this study, ospemifene was compared with tamoxifen ...
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