eukaryotic initiation
The role of eukaryotic initiation factor 2α during the metabolic depression associated with estivation
... of eukaryotic initiation factor 2α (eIF2α) in two estivating organisms previously shown to downregulate protein synthesis during metabolic depression, the land snail Helix aspersa Müller and the desert frog ...
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Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia
... of eukaryotic initiation fac- tor (eIF) 4E activity slows G1 progression in yeast [13] and non-transformed mammalian cells ...translation initiation and is thought to function through eIF4F, a ...
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Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer
... eIF5A2: eukaryotic initiation factor 5A2; EMT: epithelial-mesenchymal transition; DHPS: deoxy- hypusine synthase; DOHH: deoxyhypusine hydrox- ylase; cDNA: complementary deoxyribonucleic acid; mRNA: message ...
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Binding Specificities and Potential Roles of Isoforms of Eukaryotic Initiation Factor 4E in Leishmania
... fully replace the yeast eIF4E gene, whereas At.eIF4E-2, which encodes eIF(iso)4E, provides only partial complementation and the recovered yeast cells grow very slowly (54). The ge- nome of Drosophila melanogaster also ...
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Modification of eukaryotic initiation factor 4F during infection by influenza virus.
... Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Ad infection results in a specific block in cellular protein synthesis mediated in part by a drastic reduction in the pho[r] ...
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Relationship of eukaryotic initiation factor 3 to poliovirus-induced p220 cleavage activity.
... To assay the p220-specific cleavage activity in poliovirus-infected cell extracts, each 10-pl reaction mixture contained 2 [L1 of postmitochondrial supernatant from uninfected HeLa cells[r] ...
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Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site.
... The extended stem-loop structures of the IRES element probably serve as binding sites for proteins which play a role as trans-active factors during the unusual mechanism of transla- tion initiation of these ...
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Involvement of the eukaryotic initiation factor 6 and kermit2/gipc2 in Xenopus laevis pronephros formation
... ABSTRACT The translation initiation factor Eif6 has been implicated as a regulator of ribosome assembly, selective mRNA translation and apoptosis. Many of these activities depend upon the phosphorylation of eif6 ...
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Multiple isoelectric forms of poliovirus RNA-dependent RNA polymerase: evidence for phosphorylation.
... The host cell protein required for in vitro replication of poliovirus is a protein kinase that phosphorylates eukaryotic initiation factor 2.. ATP is required for initiation of polioviru[r] ...
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PKR and PP1C Polymorphisms in Alzheimer’s Disease Risk
... Alzheimer’s disease (AD) is a neurodegenerative disease characterized by senile plaques and neurofibrillary tangles. Senile plaques are deposits of amyloid ß-peptide (Aß) produced by the cleavage of a transmembrane ...
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Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma
... translation initiation is coupled with cell cycle progression and cell growth, whereas excessive ribo- some biogenesis and translation initiation often lead to tumor transformation and ...of ...
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mRNA Translation Regulation by the Gly-Ala Repeat of Epstein-Barr Virus Nuclear Antigen 1
... translation initiation are the classic cap-dependent and the less frequent cap-independent translation mechanisms (5, 7, 11, 14, ...and eukaryotic initiation factor 2 ␣ phosphorylation ...
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Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
... Translation initiation in eukaryotes requires the parti- cipation of several eukaryotic initiation factors (eIFs), and the eIF3 is the largest and most complex of the eIFs, consisting of 13 subunits ...
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Efficient Translation of Rotavirus mRNA Requires Simultaneous Interaction of NSP3 with the Eukaryotic Translation Initiation Factor eIF4G and the mRNA 3′ End
... the eukaryotic initiation factor eIF4G (14, 23, ...first initiation codon ...accurate initiation when competition exists between mRNA (27) or when the supply of ribosomes or initiation ...
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Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... and eukaryotic initiation factor 2 in heme-deficient or double- residues within the ε-subunit of eukaryotic translation initiation stranded RNA-inhibited reticulocyte ...
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Mammalian target of rapamycin signaling in diabetic cardiovascular disease
... ATM: ataxia-telengiectasia; Deptor: DEP domain-containing mTOR interacting protein; DM: diabetes mellitus; 4EBP1: eukaryotic initiation factor 4E-binding protein 1; eIF4E: eukaryotic tra[r] ...
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Amphitrite: a program for processing travelling wave ion mobility mass spectrometry data
... Hershey, Methodology for measuring conformation of solvent-disrupted protein subunits using T-WAVE ion mobility MS: an investigation into eukaryotic initiation factors, Journal of the Am[r] ...
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Studying Hepatitis C Virus: Making the Best of a Bad Virus
... after initiation, and may increase the efficiency of termination and ribosome recycling ...novo initiation of minus-strand synthesis, probably via interaction with one or more viral and host proteins to ...
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Influenza A Virus-Induced Degradation of Eukaryotic Translation Initiation Factor 4B Contributes to Viral Replication by Suppressing IFITM3 Protein Expression
... of eukaryotic translation initiation factor 4B (eIF4B), an integral component of the translation initiation apparatus, was dramatically reduced in A549 cells as well as in the lung, spleen, and ...
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Translation initiation events on structured eukaryotic mRNAs generate gene expression noise
... Inhibitory structures are present in the 5 UTRs of a size- able subset of eukaryotic mRNAs that includes many reg- ulatory mRNA species (53,54). Intriguingly, many of the hundreds of yeast mRNAs with highly ...
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