eukaryotic initiation factor 6
Involvement of the eukaryotic initiation factor 6 and kermit2/gipc2 in Xenopus laevis pronephros formation
... translation initiation factor Eif6 has been implicated as a regulator of ribosome assembly, selective mRNA translation and ...growth factor (IGF) ...
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Binding Specificities and Potential Roles of Isoforms of Eukaryotic Initiation Factor 4E in Leishmania
... translation factor, since in higher eukaryotes, the majority of the eIF4E is found in the postribosomal supernatant and in 48S ...distinct factor for stabilizing the interaction between the ribosome and cap ...
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Diverse roles of endoplasmic reticulum stress sensors in bacterial infection
... : eukaryotic translation initiation factor 2 α ; ER: endoplasmic reticulum; ERAD: ER-associated degradation; ESAT-6: early secretory antigenic target 6; Grp94: heat shock protein 90 kDa ...
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Original Article Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia
... EIF3B, as a subunit of the EIF3 family, plays a crucial role in stimulation of cell growth-regulat- ing protein synthesis, which contributes to the oncogenic progression of several cancers [14]. Existing studies show ...
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Protein Synthesis and Endoplasmic Reticulum Stress Can Be Modulated by the Hepatitis C Virus Envelope Protein E2 through the Eukaryotic Initiation Factor 2α Kinase PERK
... the effects of ER stress specifically through inhibition of PERK, we analyzed eIF2␣ phosphorylation under ER stress conditions in the E2-expressing cell lines. Tg, which promotes the depletion of lumenal calcium stores, ...
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Efficient Translation of Rotavirus mRNA Requires Simultaneous Interaction of NSP3 with the Eukaryotic Translation Initiation Factor eIF4G and the mRNA 3′ End
... of 6 histidine residues in Escherichia coli using the T7 expression system (32) has been described previously ...lation initiation and copurification of a truncated C-terminal fragment of ...
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Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC
... Lung cancer is a common malignant disease and the leading cause of cancer-related death in the world [1], which falls into the broad categories of non– small cell lung cancers (NSCLC, encompassing lung adenocarcinomas, ...
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Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer
... Translation initiation is the most well-studied in cancer [7]. Translation initiation is regulated by eukaryotic translation factor 4F (EIF4F) heterotrimeric complex, which is consisted of ...
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Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia
... All mice strains were maintained on a C57BL/6 back- ground. CAGs-RIK mice were crossed to sh4E.389, sh4E.610 and shFLuc.1309 mice [14] to generate bi- transgenic animals. Mice harboring the shFLuc.1309 al- lele ...
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Influenza A Virus-Induced Degradation of Eukaryotic Translation Initiation Factor 4B Contributes to Viral Replication by Suppressing IFITM3 Protein Expression
... within 6 days postinfection, whereas approximately 46% of wild- type littermates remained alive on day 6 postinfection, and even about 23% of the wild-type mice survived at the end of the exper- iments (at ...
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Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
... 10 6 clones screened, 8 positive clones were iso- lated using the most stringent reporter ...the eukaryotic translation initiation factor 3 ...
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The role of eukaryotic initiation factor 2α during the metabolic depression associated with estivation
... especially true when long-term changes are involved, as changes in this ratio can occur without changes in the amount of eIF2α(P). We overcame this problem by totally phosphorylating all of the endogenous eIF2α in a ...
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Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma
... translation initiation is coupled with cell cycle progression and cell growth, whereas excessive ribosome biogenesis and translation initiation often lead to tumor transformation and ...of eukaryotic ...
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Helper Component Proteinase of the Genus Potyvirus Is an Interaction Partner of Translation Initiation Factors eIF(iso)4E and eIF4E and Contains a 4E Binding Motif
... the eukaryotic translation initiation factor eIF4E and the isoform eIF(iso)4E, which interact with viral genome-linked protein ...translation initiation factors and were detrimental to the ...
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Relationship of eukaryotic initiation factor 3 to poliovirus-induced p220 cleavage activity.
... To assay the p220-specific cleavage activity in poliovirus-infected cell extracts, each 10-pl reaction mixture contained 2 [L1 of postmitochondrial supernatant from uninfected HeLa cells[r] ...
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Aberrations in translational regulation are associated with poor prognosis in hormone receptor positive breast cancer
... Pdcd4 has been reported to inhibit protein translation by binding to the translation initiation factor eIF4A [45]. As pdcd4 undergoes regulated degradation by b-Trcp after phosphorylation at S67 by S6K1 ...
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Proteostatic Signaling & Control of Protein Synthesis
... transcription factor TIF-1A, and the inhibition of mTORC1 disrupts ribosomal assembly [81, ...transcription factor, resulting in its negative regulation by binding inhibitory 14-3-3 class of ...
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Studying Hepatitis C Virus: Making the Best of a Bad Virus
... NS5A is a hydrophilic phosphoprotein of unknown function (208). At least one kinase likely responsible for NS5A phos- phorylation is casein kinase I ␣ (183, 184) and, as discussed above, NS5A phosphorylation isoforms and ...
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Frequent activation of EGFR in advanced chordomas
... growth factor (bFGF), transform- ing growth factor alpha (TGF alpha) and fibronectin was reported to correlate with an increased incidence of dis- ease recurrence in chordoma ...
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Revisiting an old acquaintance: role for eIF5A in diabetes
... Dysfunction of pancreatic islet β cells underlies both type 1 and type 2 diabe- tes and appears to result in part from the local release of proinflammatory cytokines. An improved understanding of the mechanisms that ...
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