Eukaryotic translation initiation complex
Eukaryotic translation initiation factor 2B beta (eIF2B β), a new class of plant virus resistance gene
... Accepted Article This article is protected by copyright. All rights reserved. resistant and susceptible types in order to look at the origin and evolution of the resistance. The presence of multiple copies of eIF2Bβ in ...
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Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
... local translation and synaptic plasti- city in dendrite ...synaptic translation and in the pathophysiology of diseases associated with mutations in these ...
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Investigating the role of SUMOylation of eukaryotic translation initiation factors
... 4E-BP Family The eIF4E binding proteins (4E-BPs) are key regulators of protein synthesis. 1-3 As their name suggests, they function by interacting with eIF4E. This inhibits eIF4E function by prevent- ing it from ...
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Complex Formation between Potyvirus VPg and Translation Eukaryotic Initiation Factor 4E Correlates with Virus Infectivity
... the translation pro- cess but exhibit differences in their ability to bind m 7 GTP and other cap analogues (8), as well as in their expression in dif- ferent organs ...various initiation factor isomers and ...
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Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... ternary complex formation in vivo, The efficiency of suppression of both the PKR-induced increasing the level of initiator tRNA may overcome the growth phenotype and the absence of eIF2B correlated requirement for ...
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Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site.
... internal translation ini- tiation (and is destroyed by several members of the picorna- virus family in the infected cell), other properties of this ini- tiation factor may also be essential to IRES-dependent ...a ...
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Insights into Eukaryotic Translation Initiation from Mass Spectrometry of Macromolecular Protein Assemblies
... studying complex pro- cesses such as translation ...upon complex formation with the ribosome and is therefore likely poised for interact- ing with further eIFs during formation of the 43S ...
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Translation initiation events on structured eukaryotic mRNAs generate gene expression noise
... manifest translation- generated ...optimal translation of mRNAs bearing longer, more complex, 5 UTRs ...(48). Translation efficiency mea- surements from a recent high-throughput study that ...
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EUKARYOTIC TRANSCRIPTION- INITIATION, ELONGATION AND TERMINATION
... Three Eukaryotic RNA Polymerases The features of eukaryotic mRNA synthesis are markedly more complex those of ...Each eukaryotic polymerase also requires a distinct set of transcription ...
Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease
... 80S initiation complex, which is a clas- sical assay to simulate the formation of the first peptide bond during protein ...80S initiation complex does not require eIF5A1, so eIF5A1 was ...
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Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1): a target for cancer therapeutic intervention?
... cap-dependent translation, however, EIF4G2 isoform is involved in IRES-dependent transla- tion in cells [20, ...EIF4F complex such as EIF4E and EIF4A and other components that start cap-depend- ent ...
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Severe Acute Respiratory Syndrome Coronavirus Protein nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation
... primer-RNA complex and purified 60S subunits were added to the sample and incubated for 20 min at ...binary complex and 48S- and 80S-specific toeprint signals were mea- sured by densitometric scanning of ...
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A Genetic Screen for Maternal-Effect Suppressors of decapentaplegic Identifies the eukaryotic translation initiation factor 4A in Drosophila
... In contrast, histidine is largely uncharged. In addition, this arginine is conserved among all the eIF4A proteins from yeast to humans and is only one amino acid away from motif V, which is conserved among all the DEAD- ...
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Eukaryotic translation initiation factor 4All contributes to microRNA-122 regulation of hepatitis C virus replication
... to translation inhibition and mRNA ...a complex of proteins known as the RNAi-induced silencing complex (RISC), in which an Arg- onaute protein (Ago1–4 in mammals) is the central compo- nent ( 6 ...
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Studies of the purification of eukaryotic initiation factor 4A
... preinitiation complex may be the rate-limiting step in translation initiation, for the 48S complex can only be Isolated in the absence of 60S ribosomal sub-units, or in the presence of ...
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Incorporation of Eukaryotic Translation Initiation Factor eIF4E into Viral Nucleocapsids via Interaction with Hepatitis B Virus Polymerase
... To our knowledge, it is unprecedented that a translation factor such as eIF4E is incorporated into viral nucleocapsid particles. The pgRNA could enhance the HBV Pol-eIF4E interaction as a consequence of tethering, ...
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Mutation of Eif4g3, encoding a eukaryotic translation initiation factor, causes male infertility and meiotic arrest of mouse spermatocytes
... The translation of eukaryotic mRNAs occurs via three basic steps: initiation, elongation and ...termination. Translation initiation requires binding of the translation ...
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Identification in the Ancient Protist Giardia lamblia of Two Eukaryotic Translation Initiation Factor 4E Homologues with Distinctive Functions
... fide initiation factor performing the function of a scaffold in the translation initiation complex of ...in translation initiation in Giardia (unpublished data), whereas ...
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Review Article Implications of the Use of Eukaryotic Translation Initiation Factor 5A (eif5a) for Prognosis and Treatment of Hepatocellular Carcinoma
... eukaryotes, translation of messenger RNA (mRNA) to a polypeptide is a key process in protein ...(1) initiation of translation, (2) elongation of polypeptide chain, and (3) termination of ...the ...
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Detailed Analysis of the Requirements of Hepatitis A Virus Internal Ribosome Entry Segment for the Eukaryotic Initiation Factor Complex eIF4F
... in translation extracts in which eIF4G is cleaved by the picorna- virus 2A or Lb ...eIF4F complex known at that time to be cleaved by both the 2A and Lb proteinases, it was concluded that HAV IRES function ...
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