Ewing sarcoma
Localized Ewing sarcoma of the tibia
... Ewing sarcoma (ES) is a malignant tumour of bone which is composed of small round tumour cells [1,2]. It accounts for 6-8% of all primary malignant bone tumours and pre- dominantly affects children, ...
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Clinical implications of six inflammatory biomarkers as prognostic indicators in Ewing sarcoma
... were grouped by the cutoff values and survival analyses were conducted. Because only a small proportion of patients have two points of GPS and NPS, patients with scores of 1 and 2 were grouped together when calculating ...
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The Evaluation of Osteosarcoma and Ewing Sarcoma by Bone Markers in Children and Adult after Chemotherapy
... Ewing sarcoma (aged between 5 and 20 years) admitted in the hospital of Constantine named BENBADIS were reviewed in a prospective study. The inclusion criteria were a primary bone tumor confirmed by ...
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Programmed cell death-1 blockade in recurrent disseminated Ewing sarcoma
... Ewing sarcoma (EWS) is a poorly differentiated, aggressive malignant small blue round cell tumour of the bone and soft tissue [1]. It accounts for 34 % of primary bone tumours in people <20 years with an ...
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Molecular pathogenesis and targeted therapeutics in Ewing sarcoma/primitive neuroectodermal tumours
... treating Ewing sarcoma/PNET ...of Ewing/PNET had a rapid response to AMG 479 with a partial response on posi- tron emission tomography-CT on day ...additional Ewing/PNET patients were enrolled ...
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Primary Vulvar Ewing Sarcoma in a 30 Year Old Woman: A Case Report
... Primary Ewing sarcoma (ES) and primitive neuroectodermal tumor (PNET) are considered Ewing sarcoma family of tumors (ESFT), characterized by chromo- somal translocation t(11; 22) (q24; q12) ...
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The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma
... Microarray analysis revealed genes of the posterior HOXD locus normally involved in bone formation to be over-expressed in primary Ewing sarcoma (ES). The expression of posterior HOXD genes was not ...
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A bivalent promoter contributes to stress-induced plasticity of CXCR4 in Ewing sarcoma
... most Ewing sarcoma cells do not express high levels of CXCR4 ...two Ewing sarcoma cell lines, CHLA-25 and TC-32, exist in an equilibrium state wherein 30-40% of cells express high levels of ...
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Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development
... Ewing sarcoma gene EWS was first identified from the Ewing sarcoma chromosomal breakpoint t(11;22)(q24;q12) region as a translocation-generated fusion gene product between EWS and FLI1, a ...
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<p>Management of recurrent Ewing sarcoma: challenges and approaches</p>
... The role of radiotherapy for recurrent pulmonary metas- tases is less clear. Most cooperative group studies prescribe 15–18 Gy of whole lung irradiation (WLI) as planned treat- ment for newly diagnosed patients who have ...
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Radiotherapy for Ewing sarcoma: A 5 year experience from Iran cancer institute
... Presence of metastases, age at diagnosis, positive surgical margin and tumor size were the prognostic factors that in;luenced outcome of patients including local control and survival. This study suggests that radiation ...
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Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma
... Ewing sarcoma (ES) is a highly aggressive pediatric cancer that may arise from neuronal precursors. Neurotrophins stimulate neuronal devlopment and plasticity. Here, we found that neurotrophins nerve growth ...
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Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1
... of Ewing Sarcoma in order to evaluate the therapeutic potential of inhibiting its epigenetic reading activity both in vitro and in ...in Ewing sarcoma cell lines and in in vivo tumor ...the ...
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The role of AXL and the in vitro activity of the receptor tyrosine kinase inhibitor BGB324 in Ewing sarcoma
... New targets for Ewing sarcoma (ES) patients are urgently needed. Therefore, we investigated the expression and genetic aberrations of the oncogenic receptor tyrosine kinase (RTK) AXL in ES and determined ...
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CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis
... Ewing sarcoma (EWS) is an aggressive bone tumor of uncertain cellular origin. CD99 is a membrane protein that is expressed in most cases of EWS, although its function in the disease is unknown. Here we have ...
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Long noncoding RNA EWSAT1 mediated gene repression facilitates Ewing sarcoma oncogenesis
... in Ewing sarcoma cells (Supplemental Figure 3C) after knockdown of ...A673 Ewing sarcoma ...A673 Ewing sarcoma cell line did not result in an increased capacity of the cells to ...
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EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma
... To attribute increases in cell area and number of focal adhesions specifically to depletion of NKX2-2 either by an NKX2-2-specific shRNA or by knocking down EWS/FLI, we performed rescue experiments in A673 cells (Fig. ...
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Detection of circulating tumor cells in liquid biopsy from Ewing sarcoma patients
... cell/mL). Ewing sarcoma family tumor cells derived from tissue biopsies of patients with fusion transcript EWSR1/FLI1 type 1 (A), EWSR1/FLI1 type 2 (B), and with EWSR1/ERG type 1 ...
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Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting
... in Ewing sarcoma, though the genomic implications of this result as well as a narrowed focus on H3K4 at regions of interest remain the work of continued ...
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Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy.
... F I G U R E 2 Effect of KDM1A inhibitors on the cell proliferation of Ewing sarcoma spheroids. Growth curve of A673 spheroids treated with a range of concentrations of KDM1A inhibitors ORY-1001 (A) and ...
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