exonic splicing
Evolutionary conservation analysis increases the colocalization of predicted exonic splicing enhancers in the BRCA1gene with missense sequence changes and in frame deletions, but not polymorphisms
... by exonic splicing silencers and exonic splicing enhancers ...Single exonic nucleotide sequence variations resulting in altered mRNA transcript splicing have also been reported ...
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Structural, functional, and protein binding analyses of bovine papillomavirus type 1 exonic splicing enhancers.
... Alternative splicing plays an important role in regulation of bovine papillomavirus type 1 (BPV-1) gene ...purine-rich exonic splicing enhancers (SE1 and SE2) which also stimulate splicing of ...
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Selection of the bovine papillomavirus type 1 nucleotide 3225 3' splice site is regulated through an exonic splicing enhancer and its juxtaposed exonic splicing suppressor.
... Alternative splicing is an important mechanism for the regulation of bovine papillomavirus type 1 (BPV-1) gene expression during the virus life ...vitro splicing in HeLa cell nuclear extracts to identify ...
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An Exonic Splicing Silencer Downstream of the 3′ Splice Site A2 Is Required for Efficient Human Immunodeficiency Virus Type 1 Replication
... unique splicing pattern since it includes an exon within the env gene (exon 6), through utilization of cryptic 3 ⬘ ss A6 ...overall splicing of viral RNA was increased, which was correlated with decreased ...
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Regulation of vif mRNA Splicing by Human Immunodeficiency Virus Type 1 Requires 5′ Splice Site D2 and an Exonic Splicing Enhancer To Counteract Cellular Restriction Factor APOBEC3G
... alternative splicing (22). Alternative splicing of HIV-1 RNA results in the production of approximately 40 different mRNA species, which include three different mRNA size classes: ...cis splicing ...
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Exonic Splicing Enhancer-Dependent Selection of the Bovine Papillomavirus Type 1 Nucleotide 3225 3′ Splice Site Can Be Rescued in a Cell Lacking Splicing Factor ASF/SF2 through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway
... Two exonic splicing enhancers, each containing two ASF/SF2 (alternative splicing factor/splicing factor 2) binding sites, are located between the two 3 ⴕ splice sites and have been identified ...
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Optimization of a Weak 3′ Splice Site Counteracts the Function of a Bovine Papillomavirus Type 1 Exonic Splicing Suppressor In Vitro and In Vivo
... Alternative splicing is a critical component of the early to late switch in papillomavirus gene ...viral splicing elements have recently been identified between the two alternative 3 ⴕ splice sites and have ...
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Function of a Bovine Papillomavirus Type 1 Exonic Splicing Suppressor Requires a Suboptimal Upstream 3′ Splice Site
... alternative splicing (3, 29). Splicing of the majority of mRNAs at early stages of the viral life cycle utilizes a common 39 splice site at nucleotide (nt) 3225 even though alternative 39 splice sites are ...
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RNA Splicing at Human Immunodeficiency Virus Type 1 3′ Splice Site A2 Is Regulated by Binding of hnRNP A/B Proteins to an Exonic Splicing Silencer Element
... alternative splicing of a single primary RNA ...cells. Splicing of Tat mRNA, which is present at relatively low levels in infected cells, is repressed by the presence of exonic splicing ...
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Reprogramming Alternative Splicing Using Cis Acting Intronic Control Elements
... and exonic cis-elements are the serine/arginine-rich (SR) and SR-like ...between splicing factors bound to the 5‟ and 3‟ splice ...the splicing machinery 5 . Most exonic splicing ...
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Why eukaryotic cells use introns to enhance gene expression: Splicing reduces transcription-associated mutagenesis by inhibiting topoisomerase I cutting activity
... from exonic splicing signals. Long intron splicing is more likely to require the recruitment SR or SR-like ...other splicing-related pro- teins are also found to interact with human topoisome- ...
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Conservation of CD44 exon v3 functional elements in mammals
... alternative splicing route different from that affecting other variable exons so it can be included in the mRNA together with other variable exons or independently from them ...bipartite exonic ...
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Utilization of the Bovine Papillomavirus Type 1 Late-Stage-Specific Nucleotide 3605 3′ Splice Site Is Modulated by a Novel Exonic Bipartite Regulator but Not by an Intronic Purine-Rich Element
... purine-rich exonic splicing enhancer that has a strong affinity for SR proteins and regulates utilization of the nt 3225 3⬘ splice site in BPV-1 late pre-mRNAs (54, ...its exonic location with ...
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Serine/Arginine-Rich Splicing Factor 3 and Heterogeneous Nuclear Ribonucleoprotein A1 Regulate Alternative RNA Splicing and Gene Expression of Human Papillomavirus 18 through Two Functionally Distinguishable cis Elements
... RNA splicing to produce a repertoire of viral transcripts for the expression of individual viral ...RNA splicing re- main unknown. In this study, an exonic splicing enhancer (ESE) in the ...
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Calculation of Splicing Potential from the Alternative Splicing Mutation Database
... strengthen splicing of the exon, the algorithm increases their potential values by the value SP i = log 10 (w), where w = 1+abs(SE) and index i is the case ...the splicing of the exon, the algorithm ...
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spp42, Identified as a Classical Suppressor of prp4-73, Which Encodes a Kinase Involved in Pre-mRNA Splicing in Fission Yeast, Is a Homologue of the Splicing Factor Prp8p
... temperature. spp42 encodes a large protein (p275), which is the homologue of Prp8p. This protein has been shown in budding yeast and mammalian cells to be a bona fide pre-mRNA splicing factor. Taken together with ...
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Operative sequentiality in tumor differentiation and progression as protein molecular structure and sequence context in modulating alternative splicing events
... alternative splicing that not only affects pri- marily the distributional dimensions of isoforms of various protein species but especially influences the nature of interactivity events between various protein ...
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Alternative splicing in plant defence
... 1.2.2.2.1 SR proteins SR proteins are a conserved family of pre-mRNA splicing factors that are concerned with the execution of constitutive splicing and alternative splice site choice in[r] ...
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Trans-acting Factors Required for Inclusion of Regulated Exons in the Ultrabithorax mRNAs of Drosophila melanogaster
... Screening protocol: We reasoned that the tissue-specific Ubx the quantitations of Ubx isoform ratios were performed splicing pattern should be sensitive to the zygotic dose of on samples amplified through the 22nd ...
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EuropePMC-PMC5069560.pdf
... and exonic regions for each of the cell cycle genes of group a (left side of Supplementary Table ...or exonic regions of these two sets of genes (group a versus group b) however the total number of CLIP ...
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