expression of Cx43
Original Article Expression of CX43 and SOCS-1 in patients with sudden cardiac death
... Sudden cardiac death (SCD) is an unexpected death due to cardiac causes occurring in a short time period (generally within 1 h of sy- mptom onset) [1]. Epidemiological study has shown that the incidence of SCD is ...
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Increased expression of CX43 on stromal cells promotes leukemia apoptosis
... of Cx43 inducing apoptosis on cancer cells has been reported [16, 19], the molecular mechanism of Cx43-induced apoptosis remains ...or Cx43-hUCSCs for 3 hrs, L615 cells were harvested from the ...
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Original Article Molecular mechanisms of basic fibroblastic growth factor upregulates connexin43 expression in the human glioblastoma cells
... (Cx43) expression and dysfunction of gap junction intercellular communication (GJIC) is associated with increasing proliferation and the grade of human glioma ...connexin43 expression, however, the ...
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Original Article Modulation of connexin 43 expression by histone acetylation dependent mechanisms in human bladder smooth muscle cells
... (HBSMCs). Expression of Cx43 mRNA was assessed by RT-PCR and qPCR after treatment of HBSMCs with either the histone deacetylase (HDAC) inhibi- tor, trichostatin A (TSA) or the histone acetyltransferase ...
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Original Article Irbesartan reduces chronic ischemic myocardial injury by up-regulating connexin 43 expression in rats
... the expression of Cx43 was significantly down-regulated in infarcted rats, as compared with control and sham ...[18]. Cx43 plays role in regulating cardiac function by mediating the contraction of ...
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Fluoxetin Upregulates Connexin 43 Expression in Astrocyte
... on expression of Cx43 and AQP4 in astrocytic cell lines through cAMP and its newly de- scribed downstream Epac (exchange protein directly ac- tivated by cAMP) (Kawasaki, Springett et ...
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Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium.
... in Cx43 protein ...the expression of Cx43 protein in the heart by the JNK pathway resulting in slowed cardiac action potential conduction and an increased risk of arrhythmias in the ageing ...
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Behrens, Juliane (2011): A channel independent function of connexin 43 in cell migration. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... that Cx43 enhances serum-stimulated migration of HeLa ...of Cx43 as we used live cell imaging and tracked the cell path of single ...that expression of Cx43 reduces cell proliferation 69 126 ...
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Original Article Correlation analysis between the protein expression of AKAP95, cyclinE, and Cx43 in breast cancer
... the expression of skp2 and reducing the degradation of p27, Cx43 could inhibit cell G1/S phase transformation [4, ...that Cx43 plays an important role in controlling cells as a tumor-suppressor ...
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Close the Gap : a study on the regulation of Connexin43 gap junctional communication
... N-cadherin expression is linked to stress fibre organisation, focal adhesion formation or activation of Rho family ...of Cx43-based GJC did not rescue the migration phenotype, sug- gesting that that the ...
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Original Article Relationship of vasculogenic mimicry, SphK1 expression, and Cx43 expression to metastasis and prognosis in colorectal cancer
... and expression of Sphingosine kinase 1 (SphK1) and Connexin43 (Cx43) in colorectal cancer (CRC) tissues, and to identify their inter-relationships and associations with multiple pathologic ...for ...
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A novel role of Cx43-composed GJIC in PDT phototoxicity: an implication of Cx43 for the enhancement of PDT efficacy
... that Cx43-composed GJIC may exhibit an effect on PDT ...by Cx43 in phototoxic action of PDT, Cx43 expression and GJ function at the condition of high-cell density were manipulated by two ...
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Cx43 Reduces Melanoma Growth Within a Keratinocyte Microenvironment and During Tumorigenesis in vivo
... and Cx43 rendering them gap junctional intercellular communication (GJIC) deficient as elucidated by immunofluorescence, Western blotting and dye transfer ...ectopic expression of green fluorescent protein ...
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Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro
... Rictor expression and cardiomyocyte differentiation of the mouse embryonic stem (mES) ...the expression and distribution patterns of cell-cell junction ...
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<p>High Glucose Downregulates Connexin 43 Expression and Its Gap Junction and Hemichannel Function in Osteocyte-like MLO-Y4 Cells Through Activation of the p38MAPK/ERK Signal Pathway</p>
... MLO-Y4 cells were grown on glass coverslips in 24-well plates and treated when they reached 60% con fl uence. The cells were divided into four groups: a) control group treated with culture media only, b) high glucose ...
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Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells
... promotes Cx43 phosphorylation and the formation of intercellular gap junctions with ...CXCR2 expression in HMEC; in turn, CXCR2 increases Cx32 expression and induces ATP ...
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Conflicting Roles of Connexin43 in Tumor-Induced Inflammation and Cancer Pathology
... Intercellular diffusion of glucose in CNS via GJ composed of Cx43 between astrocytes is downregulated by cytokines secreted from HCs of microglia. Opposingly when glucose uptake in each astrocyte is increased, ...
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S-nitrosylation of connexin43 hemichannels elicits cardiac stress–induced arrhythmias in Duchenne muscular dystrophy mice
... aberrant expression and remodeling of the cardiac gap junction protein connexin43 ...remodeled Cx43 protein forms Cx43 hemichannels in the lateral membrane of Dmd mdx cardiomyocytes and that the ...
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<p>The Multifunction Of miR-218-5p-Cx43 Axis In Breast Cancer</p>
... gene expression by directly interacting with an mRNA target, thus leading to either degradation of the mRNA transcription or inhibition of the translation ...
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Emerging roles of gap junction proteins connexins in cancer metastasis, chemoresistance and clinical application
... of Cx43 (MAbE2Cx43) in combination with or without radiotherapy led to de- creased tumor burden and increased survival ...overexpressing Cx43-YFP were harvested and processed into vesicles of similar size ...
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