extracellular growth factor-1
Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies
... The extracellular regions of these receptors contain three immunoglobulin (Ig)-like domains (designated as IgI, IgII, and IgIII) linked to the cytoplasmic domain via a transmembrane α-helix (Figure ...FGFRs ...
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Antibodies Directed against the Extracellular Region of the Epidermal Growth Factor Receptor Adopt Distinct Modes of Binding and Inhibition
... The availability of free and bound structures of VHH IA1 allows us to compare the conformational changes that occur in this VHH upon epitope binding. The framework region of the Ig fold is essentially identical in bound ...
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Extracellular matrix protein 1 regulates cell proliferation and trastuzumab resistance through activation of epidermal growth factor signaling
... Protein stabilization, shown as an increase in protein half-life, frequently represents a physical interaction be- tween protein molecules in the course of functional ac- tivity. The signaling and trafficking activities ...
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Transforming growth factor beta-1 expression in macrophages of human chronic periapical diseases.
... regulatory factor with multiple functions, TGF-b1 participates in several important pathophysiological processes, and is currently studied ...and extracellular matrix (Kingsley, 1994; Fox and Lovibond, ...
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Inorganic pyrophosphate generation by transforming growth factor beta 1 is mainly dependent on ANK induction by Ras/Raf 1/extracellular signal regulated kinase pathways in chondrocytes
... technology. PCR was performed with SYBR green master mix system (Qiagen S.A., Courtaboeuf, France). The gene-specific primer pairs are described in Table 1. Melting curve was per- formed to determine the melting ...
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Spheroid formation of human thyroid cancer cells under simulated microgravity: a possible role of CTGF and CAV1
... neutrophic factor; CAV: Caveolin; CN: Clinostat; CTGF: Connective tissue growth factor; EGF: Epidermal growth factor; ERK: Extracellular signal-regulated kinase; FCS: Fetal calf ...
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LL-37 stimulates the functions of adipose-derived stromal/stem cells via early growth response 1 and the MAPK pathway
... of extracellular signal-regulated kinase, p38, or c-Jun N-terminal kinase blocked the stimulatory effect of ...endothelial growth factor, thymosin beta-4, monocyte chemoattractant protein-1, ...
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Identification of candidate genes for myeloma-induced osteocyte death based on microarray data
... (Table 1), and the pathways of protein digestion, absorption, and extracellular matrix (ECM)-receptor interaction path- way (Table ...epidermal growth factor (EGF), ...
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Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins
... Fibroblast growth factor receptors (FGFRs) are integral membrane proteins that transmit signals through the plasma ...glycosylated extracellular part of ...fibroblast growth factor as ...
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Differential gene expression of human chondrocytes cultured under short-term altered gravity conditions during parabolic flight maneuvers
... Chondrocyte growth medium; COL2A1: Collagen type 2 α 1; CTGF: Connective tissue growth factor; ECM: Extracellular matrix; EDN1: Endothelin 1; EGF: Epidermal growth ...
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Analysis of fluG Mutations That Affect Light-Dependent Conidiation in Aspergillus nidulans
... weight factor that controls the loid, uninucleate spores on a complex multicellular ap- initiation of sporulation ( Lee and Adams ...vegetative growth to asexual sporulation strain occurred even if the two ...
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Targeting insulin-like growth factor axis in hepatocellular carcinoma
... A major advantage of small molecule inhibitor is its ability to inhibit both IGF-1R and insulin receptor. Such ability was demonstrated in several human tumor cell lines, where phosphorylated IGF-1R and its downstream ...
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Exploring the key communicator role of exosomes in cancer microenvironment through proteomics
... The exosomes secreted by lung cancer, like the exo- somes secreted by breast cancer, are also involved in tumorigenesis. Most cancers are characterized by metas- tasis only to certain organs, called organotropic metasta- ...
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Interferon-γ enhances the antifibrotic effects of pirfenidone by attenuating IPF lung fibroblast activation and differentiation
... Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) have been implicated in the pathogenesis of IPF. TGF-β1 is known to regulate the expression of several MMPs in lung fibroblasts, which in turn can par- ...
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Adult growth hormone deficiency treatment with a combination of growth hormone and insulin like growth factor 1 resulting in elevated sustainable insulin like growth factor 1 and insulin like growth factor binding protein 3 plasma levels: a case report
... However, the use of GH replacement therapy has not always resulted in consistent increases of IGF-1 in AGHD patients. The mechanism of this inconsistency has been studied by De Gennaro et al. [3]. In a series of ...
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Human Trophoblast Progenitor Cells Express and Release Angiogenic Factors
... Although little is known about trophoblast stem and progenitor cells, mesenchymal stem cells (MSCs) are considerably effective for therapeutic angiogenesis in ischemia animal models as well as clinical vascular diseases ...
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Hypoxic conditioned medium from mesenchymal stem cells promotes lymphangiogenesis by regulation of mitochondrial-related proteins
... hLECs were washed twice in ice-cold PBS, then lysed with lysis buffer (Cell Signaling, Danvers, MA, USA) containing the protease inhibitor cocktail PhosSTOP (Roche, Basel, Switzerland), and incubated at 4 °C for 30 ...
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Bioactive Compounds for the Treatment of Renal Disease
... The TGF-β superfamily includes more than twenty types of bone morphogenetic proteins (BMPs), of which BMP-7 (also called as osteogenic protein-1) is closely involved in kidney development and disease. BMPs are ...
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Expressions of Growth Factors in Autologous Derived Platelet-Rich Plasma and Platelet-Poor Plasma; Implication for Tissue Reparation and Wound Healing
... It is crucial to minimize platelet activation that occurs during PRP preparation, this is because activation results in untimely release of GFS, which could result in deletion of expressed GFs at the point of use. ...
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Ilowski, Maren (2013): Der hepatotrophe Wachstumsfaktor Augmenter of liver regeneration (ALR) wirkt leberspezifisch protektiv gegenüber metabolischen Noxen. Dissertation, LMU München: Medizinische Fakultät
... for 1 h at room temperature in blocking buffer containing 20 mM Tris, 137 mM NaCl, ...with 1:1000 dilutions (cytochrome c) in blocking buffer ...in 1:2000 dilution of anti-rabbit IgG HRP-linked as ...
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