extracellular loop
Identification of the Hepatitis C Virus E2 Glycoprotein Binding Site on the Large Extracellular Loop of CD81
... The binding of hepatitis C virus glycoprotein E2 to the large extracellular loop (LEL) of CD81 has been shown to modulate human T-cell and NK cell activity in vitro. Using random mutagenesis of a chimera of ...
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The Second Extracellular Loop of CXCR4 Determines Its Function as a Receptor for Feline Immunodeficiency Virus
... first loop of feline CXCR4 fused to the second and third loops of human CXCR4 (F5H3) or the converse chimera con- taining the N terminus and first loop of human CXCR4 fused to the second and third loops of ...
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Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae
... ABSTRACT Streptococcus pneumoniae is a leading killer of infants and immunocom- promised adults and has become increasingly resistant to major antibiotics. There- fore, the development of new antibiotic strategies is ...
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Effect of Mutations in the Second Extracellular Loop of CXCR4 on Its Utilization by Human and Feline Immunodeficiency Viruses
... variable loop (V3) of gp120 has a direct role in the selectivity for CXCR4 or CCR5, but other domains of gp120 probably con- tribute to the formation of the coreceptor-binding site (6, ...an extracellular ...
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Downregulation of Gap Junctions in Astrocytes by Monoclonal Antibodies against the Second Extracellular Loop of Connexin-43
... Downregulation of gap junctions by monoclonal antibodies against the second extracellular loop of connexin-43 (E2Cx43) was studied in a passaged culture of astrocytes. The results of confocal laser scanning ...
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Residues 28 to 39 of the Extracellular Loop 1 of Chicken Na+/H+ Exchanger Type I Mediate Cell Binding and Entry of Subgroup J Avian Leukosis Virus
... the extracellular domain of its first bound receptor (hGHbp) confer their tight binding affinity (42); the hGH-hGHbp interaction belongs to the former few strong ...
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Molecular description of non-autoimmune hyperthyroidism at a neonate caused by a new thyrotropin receptor germline mutation
... first extracellular loop of the TSHR gene leading to an exchange of an isoleucine residue for asparagine at amino acid position 486 ...the extracellular loop 1 and exhibits an increase in ...
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Signal perception by the secretion stress responsive CssRS two component system in Bacillus subtilis
... the loop regions positioned adjacent to transmembrane helices has been observed in systems additional to the Cpx system already ...periplasmic loop domain that is tethered to the face of the plasma membrane ...
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Mapping of a functional autoimmune epitope on the beta 1 adrenergic receptor in patients with idiopathic dilated cardiomyopathy
... recognized the beta 1-peptide. Only affinity-purified antibodies of these patients had a inhibitory effect on radioligand binding to the beta 1 receptor of C6 rat glioma cells. They recognized the receptor protein by ...
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CCR5 and CXCR4 Usage by Non-Clade B Human Immunodeficiency Virus Type 1 Primary Isolates
... the extracellular loops of CCR5 did not significantly affect the entry of any clade B R5 or R5X4 isolate (19, 24, ...for extracellular loop residues than the affinity of non-clade B ...the ...
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Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses.
... that extracellular loop 3 is identical in these CCR5s; thus, our studies were not informa- tive about the potential role of this region in coreceptor func- ...
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Predictive value of pre procedural autoantibodies against M2 muscarinic acetylcholine receptor for recurrence of atrial fibrillation one year after radiofrequency catheter ablation
... By using a synthetic peptide corresponding to the sequence of the second extracellular loop in human M2 receptor, we have detected anti-M2-R with ELISA and demonstrated that the frequenc[r] ...
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Localization of a functional autoimmune epitope on the muscarinic acetylcholine receptor 2 in patients with idiopathic dilated cardiomyopathy
... second extracellular loop of the human muscarinic acetylcholine receptor-2 was used as an antigen to screen sera from patients with idiopathic dilated cardiomyopathy (DCM, n = 36) and healthy blood donors ...
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A Phenomenological Model for the Electromagnetic Origin of Mass in Particles, and Its Quantitative Application to the Electron, the Muon, the Proton, and the Neutron
... the loop, and L is the selfinductance of the loop. The loop levitates while performing micrometer-range one-dimensional os- cillations under the effect of its own weight and the re- storing magnetic ...
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A twist in the tail : SHAPE mapping of long range interactions and structural rearrangements of RNA elements involved in HCV replication
... ‘kissing loop’ between SL9266 and SL9571 was analysed. The terminal loop of Con1b SL9266 was predominantly exposed in the native template (Figure 2A and C) as were the comple- mentary sequences in SL9571 ...
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Advances in closed-loop deep brain stimulation devices
... feedback loop by turning the stimulation on and off known as on- demand stimulation [31, 32, 104, ...feedback loop has the disadvantage of being affected by noise and ...
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The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity
... SDS-PAGE was executed according to Laemmli (1970). Native gel electrophoresis was carried out the same way but SDS was omitted from the sample and running buffers. Wild- type POP (4.7 µM) and loop A - POP (7.2 ...
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A twist in the tail: SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication.
... terminal loop of SL9266, there were obvious discrepancies between the NMIA accessibility of nucleotides in both the 9110 and SL9571 regions (Figure ...terminal loop) in the Con1b–luc–rep ...
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A Closed Loop Control of Quadratic Boost Converter Using PID Controller
... Closed Loop System Closed loop system is established to achieve a regulated ...closed loop QBC is simulated with P, PI and PID-controller using MATLAB simulink and the results are ...
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Fibrotic extracellular matrix activates a profibrotic positive feedback loop
... the extracellular matrix (ECM) by fibroblasts leads to organ ...feedback loop between fibroblasts and aberrant ECM. Interrupting this loop may be a strategy for IPF ...
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