Ezetimibe/simvastatin
Consistency of effect of ezetimibe/simvastatin compared with intensified lipid-lowering treatment strategies in obese and non-obese diabetic subjects
... with ezetimibe/simvastatin 10/20 mg resulted in numerically greater reductions in LDL-C compared with rosuvastatin 10 mg only in the non-obese subjects, while the combination of ezetimibe/ ...
10
Ezetimibe/Simvastatin 10/20 mg versus Rosuvastatin 10 mg in high-risk hypercholesterolemic patients stratified by prior statin treatment potency
... doses, ezetimibe/ simvastatin reduced LDL-C levels significantly more than ...with ezetimibe/simvastatin 10/20 mg (EZ/Simva) versus rosuvastatin 10 mg (Rosuva) in the overall population ...
8
Complementary therapy to target LDL cholesterol: the role of the ezetimibe/simvastatin combination
... Abstract: Cardiovascular (CV) disease remains the number 1 cause of death in the USA. Nonetheless, there has been a decline in the age-adjusted death rate for coronary heart disease (CHD) which may be due to more ...
8
Ezetimibe + simvastatin versus doubling the dose of simvastatin in high cardiovascular risk diabetics: a multicenter, randomized trial (the LEAD study)
... When ezetimibe is co-adminis- tered with a statin, complementary effects on the lipid profile have been demonstrated, without significant impact on the tolerability profile of either drug ...of ezetimibe ...
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Influence of metabolic syndrome factors and insulin resistance on the efficacy of ezetimibe/simvastatin and atorvastatin in patients with metabolic syndrome and atherosclerotic coronary heart disease risk
... of ezetimibe/simvastatin 10/20 mg versus ator- vastatin 10 mg and 20 mg, and ezetimibe/simvastatin 10/40 mg compared with atorvastatin 40 mg was evalu- ated within each subgroup using an ...
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Efficacy of Ezetimibe/Simvastatin (10/10 mg) Versus High Dose Statin in Dyslipidemia Patients: A Meta-analysis of Randomized Controlled Trials
... with simvastatin (10mg) and high-dose statin monotherapy may provide similar effects in reducing levels of LDL- C, TG, and hs-CRP and in increasing ...with ezetimibe/simvastatin ...of ...
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Low incidence of paradoxical reductions in HDL-C levels in dyslipidemic patients treated with fenofibrate alone or in combination with ezetimibe or ezetimibe/simvastatin
... The purpose of this post-hoc analysis was to explore the frequency and magnitude of paradoxical HDL-C reductions during FENO therapy in a large pooled data- base of mixed dyslipidemic patients receiving placebo, FENO ...
9
Ezetimibe/simvastatin vs simvastatin in coronary heart disease patients with or without diabetes
... with simvastatin 20 mg/day [17,18] was to evaluate the factors significantly correlated with the probability of achieving the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) recom- ...
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Changes in LDL-C levels and goal attainment associated with addition of ezetimibe to simvastatin, atorvastatin, or rosuvastatin compared with titrating statin monotherapy
... of ezetimibe to ongoing simvastatin, atorvastatin, or rosuvastatin therapy improves LDL-C reduction and goal attainment in CHD/CHD risk-equivalent patients more than uptitration of these statins or ...
9
Efficacy, safety and tolerability of ongoing statin plus ezetimibe versus doubling the ongoing statin dose in hypercholesterolemic Taiwanese patients: an open label, randomized clinical trial
... (e.g., ezetimibe, fibrates, or niacin) may be the due course of ...the Ezetimibe/ Simvastatin Tablet (BRAVO) Study (N = 173 Taiwanese sub- jects across all cardiovascular risk categories), 91% of ...
8
Synergistic effect of simvastatin and ezetimibe on lipid and pro-inflammatory profiles in pre-diabetic subjects
... to simvastatin therapy provoked a sig- nificant improvement in CRP levels and such an effect was independent of LDL-cholesterol ...with ezetimibe has been less frequently described ...that ezetimibe ...
7
HPLC METHOD DEVELOPMENT, METHOD DETERMINATION AND METHOD VALIDATION OF DOSAGE FORM OF EZETIMIBE
... Ezetimibe is a drug that lowers plasma cholesterol levels. It acts by decreasing cholesterol absorption in the small intestine. It may be used alone (marketed as Zetia or Ezetrol), when other cholesterol-lowering ...
8
Ezetimibe therapy: mechanism of action and clinical update
... to ezetimibe 10 mg/day and simvastatin 40 mg/day or ...the ezetimibe/simvastatin group ...larger ezetimibe-plus-statin trials that were ongoing at the time of the analysis did not ...
13
Simultaneous derivative and multicomponent spectrophotometric determination of Simvastatin and Ezetimibe in tablets
... Two new, simple, accurate and economical spectrophotometric methods have been developed for simultaneous estimation of simvastatin and ezetimibe in two component tablet formulation. The methods employed are ...
5
Snapshots: Endoplasmic Reticulum Stress in Lipid Metabolism and Cardiovascular Disease
... with simvastatin plus ezetimibe strongly reduces the levels of serum oxysterols and attenuates CKD- dependent atherosclerosis, vascular calcification, and cardiac dysfunction in ApoE knockout mice via ...
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Increase in Dissolution Rate of Simvastatin by Amorphous Solid Dispersion System With Hydroxypropylmethylcellulose Polymer
... DSC thermogram of simvastatin has an endothermic peak at 138.2 °C which corresponds to the melting point of simvastatin. While DSC thermogram of HPMC does not exhibit an endothermic peak, which indicates ...
5
Simultaneous spectroscopic estimation of ezetimibe and simvastatin in tablet dosage forms
... Zero-order absorption spectra of ezetimibe and simvastatin showed overlapping peaks that interfere with the simultaneous determination of this formulation (Þ g. 1). Derivative spectroscopy, based on a ...
5
Lowering low-density lipoprotein cholesterol levels in patients with type 2 diabetes mellitus
... While ezetimibe has no known effect on glycemic para- meters in patients with T2DM, ezetimibe was studied in diabetes mellitus ...of ezetimibe to existing statin therapy in patients with and without ...
10
Development and Validation of RP-HPLC Method for Simultaneous Estimation of Sitagliptin and Simvastatin in Bulk and Tablet Dosage Form
... Sitagliptin is chemically (R)-4-oxo-4-[3- (trifluoromethyl)-5,6-dihydro[1,2,4] triazolo [4,3- a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl) butan -2-amine (Figure:1). It is a Dipeptidyl peptidase - 4 (DPP-4) inhibitor. ...
9
Ongoing activities to optimize the quality and efficiency of lipid-lowering agents in the Scottish National Health System : influence and implications
... 40mg simvastatin, following publications such as the Heart Protection Study (10, ...dose simvastatin, enhanced by generic atorvastatin availability ...
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