F-MuLV
Characterization of a Live-Attenuated Retroviral Vaccine Demonstrates Protection via Immune Mechanisms
... Other attributes which may contribute to the efficacy of live- attenuated viruses as vaccines include the wide range of viral proteins which are expressed, the types of immune cells re- sponding to the infection, the ...
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Complement Opsonization Enhances Friend Virus Infection of B Cells and Thereby Amplifies the Virus-Specific CD8+ T Cell Response
... with F-MuLV-pulsed B ...C-opsonized F-MuLV- loaded B cells induced proliferation of FV-specific CD8 ⫹ T ...by F-MuLV-C-loaded B cells was significantly more pronounced ...with ...
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Mouse APOBEC3 Restricts Friend Leukemia Virus Infection and Pathogenesis In Vivo
... of F-MuLV and SFFV proviruses and ultimately causes the emergence of erythroleukemia through promoter insertion or silencing of a tumor suppressor gene ...of F-MuLV and SFFV, and others ...
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A small region of the ecotropic murine leukemia virus (MuLV) gag gene profoundly influences the types of polytropic MuLVs generated in mice.
... functions of the NC protein is a centrally located zinc finger and flanking regions containing several basic amino acids (20, 23, 29, 39, 47). Residue 37 lies within the zinc finger, and residue 23 is in the amino ...
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Nucleotide sequence of the envelope gene of Friend murine leukemia virus.
... To determine the positions of pl5env and pl2env within the precursor protein, the amino acid sequence of the F-MuLV env polypeptide was compared with the partial amino acid sequences det[r] ...
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Natural regulatory T cells inhibit production of cytotoxic molecules in CD8+T cells during low level Friend retrovirus infection
... acute F-MuLV infection, activation and expansion of FV-specific CD8 + T cells was observed (Figure 2A, ...H-2Db-restricted F-MuLV glycosylated gag ...low-level F-MuLV infection ...
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Increased hematopoiesis in mice soon after infection by Friend murine leukemia virus.
... To determine how F-MuLV affects host cell proliferation soon after infection, BALB/c mice were inoculated with virus and then were assayed for susceptibility to appropriately pseudotyped[r] ...
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Heteroduplex analysis of molecular clones of the pathogenic Friend virus complex: Friend murine leukemia virus, Friend mink cell focus-forming virus, and the polycythemia- and anemia-inducing strains of Friend spleen focus-forming virus.
... Heteroduplex mapping of molecular clones of the Friend virus complex, which includes the replication-competent ecotropic Friend murine leukemia virus F-MuLV and mink cell focus-forming v[r] ...
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Analysis of Receptor Usage by Ecotropic Murine Retroviruses, Using Green Fluorescent Protein-Tagged Cationic Amino Acid Transporters
... FIG. 4. Ecotropic receptor function of various CAT proteins. (A) Schematic diagrams of various CAT proteins tagged with GFP. In the diagram of the mCAT1-TED2 chimera, solid and open boxes represent segments derived from ...
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Protection against retroviral diseases after vaccination is conferred by interference to superinfection with attenuated murine leukemia viruses.
... Neonatal vaccination of mice with the attenuated F-MuLV B3 conferred efficient protection against both diseases induced upon infection with F-MuLV 57 as well as against acute leukemia in[r] ...
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A nonstructural gag-encoded glycoprotein precursor is necessary for efficient spreading and pathogenesis of murine leukemia viruses.
... Since glycoGag has been described to be dispensable ex vivo, we investigated the in vivo effects of a glycoGag- mutation in the Friend murine leukemia virus F-MuLV.. F-MuLV induces sever[r] ...
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Contribution of the gag and pol sequences to the leukemogenicity of Friend murine leukemia virus.
... To determine whether the F-MuLV gag and pol genes also possess sequences that affect leukemogenicity, we generated recombinant viruses between the F-MuLV gag and pol genes and two other [r] ...
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Subgenomic fragment of molecular cloned Friend murine leukemia virus DNA contains the gene(s) responsible for Friend murine leukemia virus-induced disease.
... Friend murine leukemia virus F-MuLV is a helper-independent, ecotropic, XC-positive, type C retrovirus derived from stocks of Friend virus complex F-MuLV plus spleen focus-forming virus [r] ...
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A neutralizable epitope common to the envelope glycoproteins of ecotropic, polytropic, xenotropic, and amphotropic murine leukemia viruses.
... MuLVs reactive with MAb 83A25 include all isolates of the ecotropic, xenotropic, polytropic, and amphotropic MuLV classes tested, except the Friend and Rauscher ecotropic MuLVs F-MuLV an[r] ...
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Quantitative nucleotide sequence relationships of mammalian RNA tumor viruses.
... Subgroups of mammalian RNA tumor viruses based on molecular hybridization studies Group Murine Subgroup I II I and II III IV Member MuLV-F MuLV-R MuLV-G MRTV-MG MRTV-DW MSV-SD MSV-M MSV-[r] ...
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Analysis of the unique hamster cell tropism of ecotropic murine leukemia virus PVC-211.
... PVC-211 MuLV is highly infec- tious for CHO-K1 cells, we also showed that it could efficiently infect other cell lines derived from Chinese and Syrian ham- ...PVC-211 MuLV was generated by passaging Friend ...
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A highly efficient retroviral vector allows detection of the transforming activity of the human c-fps/fes proto-oncogene.
... Compared with an isogenic vector under control of a Moloney MuLV-derived LTR, the vector driven by the F-MuLV LTR induced 3- to 10-times-higher levels of expression of c-fps/fes, a highe[r] ...
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Functional domains of Moloney murine leukemia virus integrase defined by mutation and complementation analysis.
... The HHCC region has been proposed to be involved in the recognition of the retroviral LTR termini, multimerization, positioning of the viral DNA into the catalytic core, and main- tenance of the architecture of the ...
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The spleen focus-forming virus (SFFV) envelope gene, when introduced into mice in the absence of other SFFV genes, induces acute erythroleukemia.
... Cells examined were M-MuLV-infected NIH 3T3 cells A, M-MuLV-infected NIHI 3T3 cells transfected with S52Neo/M DNA Table 1, experiment 2 B, M-MuLV-infected NIH 3T3 cells cotransfected wit[r] ...
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Revealing Domain Structure through Linker-Scanning Analysis of the Murine Leukemia Virus (MuLV) RNase H and MuLV and Human Immunodeficiency Virus Type 1 Integrase Proteins
... Plasmid DNA of the individual constructs from the final pNCA-C-XN-SU8 insertion library was transiently introduced into D17/pJET cells in the presence of DEAE-dextran. On days of confluence, cells were screened for the ...
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