fatty acid synthase
Evaluation of Circulating Fatty Acid Synthase as a Biomarker in Non Alcoholic Fatty Liver Disease
... Fatty-acid synthase (FAS) (EC 2.3.1.85"2.3.1.85) is a key enzyme in lipogenesis. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl- CoA, in the presence of ...
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Involvement of fatty acid synthase in dengue virus infection
... Immunofluorescence was undertaken essentially as de- scribed previously [24]. HEK293T/17 cells grown on glass cover slips were mock infected or infected with DENV 2 m.o.i 5 for 2 h at 4 °C with or without treat- ment of ...
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Fatty Acid Synthase Promotes the Palmitoylation of Chikungunya Virus nsP1
... pain. Fatty acid synthase (FASN) has been identified as a proviral factor for ...palmitic acid (PA) can restore the suppression of CHIKV replication by FASN ...
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Fatty Acid Synthase Inhibitor C75 Ameliorates Experimental Colitis
... of fatty acid synthase (FASN), which catalyzes the formation of long- chain fatty acids, are associated with the development of inflammatory bowel disease ...oxide synthase expression ...
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Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation
... Epidermal growth factor receptor (EGFR) is an oncogenic receptor tyrosine kinase. Canonically, the tyrosine kinase activity of EGFR is regulated by its extracellular ligands. However, ligand-independent activation of ...
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Original Article Expression of fatty acid synthase in nonalcoholic fatty liver disease
... Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation which starts with simple hepatic steatosis and may progress toward inflammation (nonalcoholic steatohepatitis ...[NASH]). ...
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Brain fatty acid synthase activates PPARα to maintain energy homeostasis
... how fatty acids, malonyl-CoA, and other metabolites act at this site to alter metabolism is poorly ...of fatty acid synthase (FAS), rate limiting for de novo lipogenesis, decreases appetite ...
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Clinicopathological significance of fatty acid synthase expression in pancreatic ductal carcinoma
... tissues, fatty acid synthase (FAS) is usually expressed in hormonesensitive and high lipid metabolism cells ...of fatty acids which contributes to tumor cellular activities [8]; metabolism ...
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Original Article CD147 promotes cervical cancer migration and invasion by up-regulating fatty acid synthase expression
... that fatty acid synthase (FAS) as a key enzymes involved in de novo fatty acid synthe- sis is overexpressed in breast cancer indepen- dent of the amount of circulating lipids ...
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Fatty Acid Synthase Mediates the Epithelial-Mesenchymal Transition of Breast Cancer Cells
... of fatty acid synthase (FASN) in the epithelial-mesenchymal transition (EMT) of breast cancer ...liver fatty acid-binding protein (L-FABP) and VEGF/VEGFR-2 in both in vitro and in vivo ...
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Cellular fatty acid synthase is required for late stages of HIV 1 replication
... v/v/v). Fatty acid methyl esters were generated by methanolysis with 3 N methanolic-HCl (85 °C over- night) followed by trimethylsilylation with Tri-Sil reagent (Thermo Scientific, Waltham, ...Heptadecanoic ...
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Polyunsaturated fatty acids reduce Fatty Acid Synthase and Hydroxy-Methyl-Glutaryl CoA-Reductase gene expression and promote apoptosis in HepG2 cell line
... Polyunsaturated Fatty Acids (PUFAs) are potent inhibitors of both enzymes, HMG- CoAR and FAS [17-19] and they have been shown to have tumoricidal action, in vitro and in vivo ...essential fatty acid ...
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Effects of soluble epoxide hydrolase inhibitor on the expression of fatty acid synthase in peripheral blood mononuclear cell in patients with acute coronary syndrome
... PBMCs were isolated from the peripheral blood by ficoll density gradient centrifugation. PBMCs (1×10 6 of the target cells per well) were cultured in complete RPMI 1640 containing 10% fetal bovine serum (FBS). The cells ...
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Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer
... In the second set of experiments, we preclinically eval- uated FASN inhibition as a therapeutic strategy in ovar- ian carcinoma. Specifically, we assessed the effects on FASN, AKT, and ERK protein expression, cell ...
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An engineered fatty acid synthase combined with a carboxylic acid reductase enables de novo production of 1-octanol in Saccharomyces cerevisiae
... for fatty alcohol production has a BY background and is based on ...the fatty acyl-CoA synthetase Δfaa2 was gener- ated using the CRISPR–Cas9 system ...
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Inhibitory effects of grape skin extract and resveratrol on fatty acid synthase
... Grape skin extract is a complex mixture of polypheno- lics, flavonoids, oligomeric proanthocyanidins, and unsat- urated fatty acids that is commonly used as a nutritional supplement. It possessed numerous ...
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Sexual dimorphism in the hepatic protein response to a moderate trans fat diet in senescence-accelerated mice
... enzymes, fatty acid synthase (FASN) and ATP citrate lyase (ACLY) increased in adult male mice fed the trans fat diet, which could explain the increased plasma triglycerides and cholesterol observed ...
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Vol. 2, Issue 10, October 2013
... Abstract: Twenty five sequences of algae were retrieved from NCBI for lipase, fatty acid synthase and glycerol 3- phosphate dehydrogenase. Physicochemical parameters were determined using pepstats, ...
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Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice
... Results: After 3 weeks of feeding, the hepatomegaly and hepatic triglyceride accumulation were markedly alleviated in the lotus polyphenol-diet-fed db/db mice relative to the control mice. Although the lipolytic enzyme ...
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Increasing medium chain fatty acids production in Yarrowia lipolytica by metabolic engineering
... Cellular fatty acids are derived from three different sources: endogenous lipid turnover, de novo synthesis and elongation, and external ...solic fatty acid synthase (FAS) catalyzes de novo ...
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