Fc gamma receptor
Novel Fc gamma receptor I family gene products in human mononuclear cells
... second Fc gamma RI family gene, termed Fc gamma ...hFc gamma RIb1, encodes a surface molecule that is not recognized by Fc gamma RI specific monoclonal antibodies when ...
9
Perinatal HIV 1 transmission: Fc gamma receptor variability associates with maternal infectiousness and infant susceptibility
... the Fc portion of HIV-1-specific immunoglobulin G (IgG) are a key component of HIV-1 protective immunity, affecting both disease pro- gression and HIV-1 ...studying Fc gamma receptor (FcγR) ...
16
Fc gamma receptor IIIa polymorphisms in advanced colorectal cancer patients correlated with response to anti EGFR antibodies and clinical outcome
... Cetuximab is an IgG1a chimeric mAb while panitumu- mab is a fully human IgG2 mAb; they bind to EGFR and block the binding of its natural ligands, preventing lig- and dependent homodimerization and activation of ...
10
Fc gamma receptor IIIb enhances Fc gamma receptor IIa function in an oxidant dependent and allele sensitive manner
... by Fc gamma RIIa in an allele-sensitive ...of Fc gamma RIIIb showed greater activation of Fc gamma RIIa after Fc gamma RIIIb cross-linking than donors homozygous ...
10
Analysis of the Fc Gamma Receptor-Dependent Component of Neutralization Measured by Anthrax Toxin Neutralization Assays
... of Fc ␥ receptors available on the cell surface can influence the magnitude of Fc ␥ receptor- dependent neutralization that is ...the Fc ␥ receptor-dependent neu- tralization ...of ...
8
Fc gamma receptor polymorphisms as predictive and prognostic factors in patients receiving oncolytic adenovirus treatment
... The polymorphism in FcgRIIIa, FcgRIIIa-V158F (rs396991), leads also to different binding affinity to IgG between the two different isoforms of the receptor. FCGRIIIA gene has a thymine (T) to guanine (G) missense ...
12
Fc gamma receptor III on human neutrophils Allelic variants have functionally distinct capacities
... of Fc gamma RIII (CD16) on neutrophils (Fc gamma ...of Fc gamma RIIIPMN on phagocytosis, we used two Fc gamma RIII-dependent probes, IgG-sensitized erythrocytes ...
10
Fc gamma receptor binding profile of anti-citrullinated protein antibodies in immune complexes suggests a role for FcγRI in the pathogenesis of synovial inflammation
... specific Fc receptors (FcR) expressed by immune cells. Fc gamma receptors (FcγR) inter- act with the IgG Fc tail and are catego- rised in the high-affinity receptor FcγRI and ...
11
Novel enzyme-linked immunosorbent assays for the detection of anti-Fc gamma receptor autoantibodies.
... which Fc g RI and Fc g RII, purified from the surfaces of U937 cells, were used to coat the ...the Fc g R antigens to prevent ligand binding, we limit ourselves to the detection of antibodies ...
6
A Case of Neonatal Neutropenia Due to Anti-Fc Gamma Receptor IIIb Isoantibodies Treated with Recombinant Human Granulocyte Colony Stimulating Factor
... with Fc gamma RIIIb deficiency (three of them pregnant women), all of them being healthy ...with Fc gamma RIIIb deficiency identified in 14 unrelated ...
5
Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB Independent mechanisms for differences in human phagocyte function
... human Fc gamma receptors have been defined: the low-responder (LR)-high-responder (HR) polymorphism of huFc gamma RIIA expressed on both PMN and monocytes and the NA1-NA2 polymorphism of the ...
9
Exacerbation of collagen induced arthritis by Fcγ receptor targeted collagen peptide due to enhanced inflammatory chemokine and cytokine production
... of Fc γ RII/III targeted CII-peptide complexes into collagen primed DBA/1 mice enhances the inflammatory TH1 driven IgG2a response to CII-peptide and stimulates inflammatory cytokine and chemokine ...to Fc ...
15
Gamma interferon augments Fc gamma receptor-mediated dengue virus infection of human monocytic cells.
... This effect is Fcy receptor mediated, because i IFN--y had no augmenting effect on the infection of U937 cells when cells were infected with dengue virus in the absence of anti-dengue an[r] ...
6
Genetic diversity in human Fc receptor II for immunoglobulin G: Fc gamma receptor IIA ligand-binding polymorphism.
... Studies of platelet activation by murine antiplatelet monoclonal antibodies via the platelet Fc-yRIIA receptor reveal three distinct patterns of behavior most likely corre-.. sponding to[r] ...
5
Fc Gamma Receptor 3A Polymorphism and Risk for HIV Associated Cryptococcal Disease
... this receptor and induces an inhibitory signal to macrophages (52), it is possible that differing affinities of GXM-IgG for FCGR2B could modify the activity of the phagocytic receptors FCGR2A and ...
11
A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer
... Monoclonal antibodies (mAbs) are an important group of targeted therapies which are directed against transmem- brane proteins with extracellular domains. Several mAbs have entered routine clinical practice: notable ...
10
Soluble Fc gamma receptor III in human plasma originates from release by neutrophils
... A patient deficient in FcRIII-1 but with a normal expression of FcRIII-2 had no soluble FcRIII in her plasma, also indicating that plasma FcRIII originates from neutrophils.. The electro[r] ...
9
Human Fc gamma RII, in the absence of other Fc gamma receptors, mediates a phagocytic signal
... of Fc gamma RIIA. These studies establish that Fc gamma RIIA can mediate phagocytosis and suggest that transfected COS-1 cells provide a model for examining this ...of Fc gamma ...
7
Low copy number of the FCGR3B gene and rheumatoid arthritis: a case control study and meta analysis
... The Fc gamma receptor 3B (FCGR3B) gene is a stimulatory receptor that is present almost exclusively on the sur- face of ...the Fc gamma receptor region (Chr 1q23-24) [14], ...
7
Association of circulating receptor Fc gamma RIII positive monocytes in AIDS patients with elevated levels of transforming growth factor beta
... immunoglobulin, Fc gamma RI and Fc gamma ...third Fc gamma R, Fc gamma RIII (CD16), which is normally associated with activation or maturation of the monocyte ...
8