Fc gamma receptor I
Third-stage Gnathostoma spinigerum larva excretory secretory antigens modulate function of Fc gamma receptor I-mediated monocytes in peripheral blood mononuclear cell culture
... cells. Fc gamma receptor I (Fc γ RI) is a high-affinity receptor that is particularly expressed on monocytes, macrophages, and dendritic ...of Fc γ RI and antigen-antibody ...
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Novel Fc gamma receptor I family gene products in human mononuclear cells
... second Fc gamma RI family gene, termed Fc gamma ...hFc gamma RIb1, encodes a surface molecule that is not recognized by Fc gamma RI specific monoclonal antibodies when ...
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Fc gamma receptor polymorphisms as predictive and prognostic factors in patients receiving oncolytic adenovirus treatment
... class I protein expression, which is needed to activate cytotoxic T lymphocyte (CTL) –mediated cell ...MHC I antigen presentation to be able to recognize and destroy an infected tumor cell since they ...
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Fc Gamma Receptor 3A Polymorphism and Risk for HIV Associated Cryptococcal Disease
... Anticryptococcal activity of NK cells is FCGR3A independent. Natural killer (NK) cells are a major cell type expressing FCGR3A. Thus, the high-affinity 158V polymorphism might affect the antifun- gal activity of NK cells ...
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Perinatal HIV 1 transmission: Fc gamma receptor variability associates with maternal infectiousness and infant susceptibility
... type I errors at the cost of type 2 errors, we considered it more important to identify potential fac- tors that may play a role in perinatal HIV-1 transmission rather than dismissing these leads as chance ...
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Novel enzyme-linked immunosorbent assays for the detection of anti-Fc gamma receptor autoantibodies.
... with Fc g Rs as soluble anti- gens. Indeed, we found that anti-Fc g R autoantibodies could be identified with a given form of Fc g R but not with other ...the Fc g RIIIb intracellular domain. ...
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Fc gamma receptor IIIa polymorphisms in advanced colorectal cancer patients correlated with response to anti EGFR antibodies and clinical outcome
... The anti-EGFR treated patients were analyzed for PFS. As of June 2011, after a median follow-up for alive patients of 22.4 months, 43 patients (87.7%) had suffered tumor progression and 19 (44.2%) had died. Median PFS ...
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In the absence of other Fc receptors, Fc gamma RIIIA transmits a phagocytic signal that requires the cytoplasmic domain of its gamma subunit
... of Fc gamma RIII, Fc gamma RIIIA, is found on NK cells, cultured monocytes, and tissue macrophages in association with a dimer of an accessory subunit, either gamma or ...individual ...
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Monocytes and polymorphonuclear neutrophils of patients with streptococcal pharyngitis express increased numbers of type I IgG Fc receptors
... enhanced Fc gamma RI expression on these cell ...of Fc gamma RI on monocytes and ...for Fc gamma RI, to quantitate the expression of this receptor on ...
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Gamma interferon augments Fc gamma receptor-mediated dengue virus infection of human monocytic cells.
... This effect is Fcy receptor mediated, because i IFN--y had no augmenting effect on the infection of U937 cells when cells were infected with dengue virus in the absence of anti-dengue an[r] ...
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RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti TNFα or anti IL 1 therapies
... Biochemical evaluation of serum markers and mediators Separate aliquots of terminal serum were used to quantify lev- els of various analytes. The serum concentration of OPG-Fc was assessed individually for ...
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The MHC class I–like Fc receptor promotes humorally mediated autoimmune disease
... class I family–like Fc receptor, FcRn, is normally responsible for extending the life span of serum IgG Ab’s, but whether this molecule contributes to autoimmune pathogenesis remains ...
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Analysis of the Fc Gamma Receptor-Dependent Component of Neutralization Measured by Anthrax Toxin Neutralization Assays
... of Fc ␥ receptors available on the cell surface can influence the magnitude of Fc ␥ receptor- dependent neutralization that is ...the Fc ␥ receptor-dependent neu- tralization ...of ...
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Expression of neonatal Fc receptor in the eye
... Our RT-qPCR findings were largely confirmed by immuno- histochemistry on human and transgenic mouse tissue. We have gone to great lengths to ensure that our hFcRn immunohistochemistry was specific. Surprisingly, the ...
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Fc gamma receptors: Glycobiology and therapeutic prospects
... antibody Fc region, which is critical for its interaction with the immune system and induction of effector activities such as antibody-dependent cell cytotoxicity, complement activation and phagocyto- ...by ...
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A major histocompatibility complex class I related Fc receptor for IgG on rat hepatocytes
... class I-like Fc receptor, or FcRn, which transports IgG in an apical to basolateral ...this receptor beyond the neonatal period within the ...class I transcripts, FcRn DNA was amplified ...
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Comparison of intravenous gamma globulin and a monoclonal anti Fc receptor antibody as inhibitors of immune clearance in vivo in mice
... FcII receptor antibody (2.4G2) into normal mice. Each agent blocked Fc-receptor function in vivo, but ...C3bi receptor antibody (Mac-1), another monoclonal antibody which binds to macrophage ...
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Monocyte surface expression of Fcγ receptor RI (CD64), a biomarker reflecting type I interferon levels in systemic lupus erythematosus
... tamine, 100 IU/ml penicillin, and 100 μg/ml streptomycin. Cytokines were from BD Bioscience, unless otherwise indicated. Cells were incubated for 19 hours at 37°C in medium containing 25% serum from either SLE patients ...
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An abnormality of the gene that encodes neutrophil Fc receptor III in a patient with systemic lupus erythematosus
... of Fc receptor III was limited to the patient's neutrophils (her natural killer cells reacted normally with anti-Fc receptor III antibodies), and was associated with abnormal recognition and ...
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Fc gamma receptor IIIb enhances Fc gamma receptor IIa function in an oxidant dependent and allele sensitive manner
... by Fc gamma RIIa in an allele-sensitive ...of Fc gamma RIIIb showed greater activation of Fc gamma RIIa after Fc gamma RIIIb cross-linking than donors homozygous ...
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