ferret model
Pathogenesis, Humoral Immune Responses, and Transmission between Cohoused Animals in a Ferret Model of Human Respiratory Syncytial Virus Infection
... Ferrets have been widely used to study human influenza virus infection. Ferrets are susceptible to human influenza viruses without requiring prior adaptation of the viruses, develop clinical signs similar to those in human ...
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Transmission of a 2009 H1N1 pandemic influenza virus occurs before fever is detected, in the ferret model
... Our experimental data support these epidemiological observa- tions, and reinforce mathematical models of pandemic spread that include a proportion of transmission occurring from pre- symptomatic individuals [3]. However ...
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Competitive Fitness of Oseltamivir-Sensitive and -Resistant Highly Pathogenic H5N1 Influenza Viruses in a Ferret Model
... virus-ferret model were affected by high virus virulence, and studies with A/Turkey/15/06 (H5N1) virus were undertaken to obtain ex- perimental evidence on the fitness of oseltamivir-resistant vari- ants ...
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In Vivo Selection of H1N2 Influenza Virus Reassortants in the Ferret Model
... the ferret model has been extensively used to study pathogenesis and transmission of influenza viruses, little has been done to determine whether ferrets are a good surrogate animal model to study ...
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A ferret model of COPD-related chronic bronchitis
... Airway obstruction in cigarette smoke–exposed ferrets. Airway obstruction is associated with COPD morbid- ity and mortality, even in patients who do not chronically expectorate mucus (12, 16). To assess for the pres- ...
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Alternative Reassortment Events Leading to Transmissible H9N1 Influenza Viruses in the Ferret Model
... methods use directed reassortment to create all or a select few of the total possible combinations, respectively (16, 17). The first of the two methods is time intensive, and although it may yield de- tailed information ...
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Progress toward generating a ferret model of cystic fibrosis by somatic cell nuclear transfer
... the ferret, efficient strategies for introducing mutations into the ferret CFTR gene must be developed in order to gener- ate appropriate somatic cell donors for NT ...
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Assessment of Influenza Virus Hemagglutinin Stalk-Based Immunity in Ferrets
... In recent years, broadly neutralizing antibodies against the con- served stalk domain of the influenza virus HA have been isolated (30, 32, 36, 37, 43, 51, 52, 53–56). These antibodies can be used for prophylactic and ...
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Severe Acute Respiratory Syndrome Coronavirus Infection of Golden Syrian Hamsters
... possible model for SARS ...the ferret model differs from that used in our study, the mean peak titer of SARS CoV observed in the upper respiratory tracts of hamsters is 10 ...
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Disease phenotype of a ferret CFTR knockout model of cystic fibrosis
... emergence of disease pathology. Here, we report the phenotype of a CFTR-knockout ferret model of CF. Neonatal CFTR-knockout ferrets demonstrated many of the characteristics of human CF disease, including ...
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Moving Forward: Recent Developments for the Ferret Biomedical Research Model
... the ferret model will allow correlates of protection to be established after vaccination and infection in conjunction with transmission studies, which are not available in the mouse ...the ferret ...
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Course of seasonal influenza A/Brisbane/59/07 H1N1 infection in the ferret
... Every year, influenza viruses infect approximately 5-20% of the population in the United States leading to over 200,000 hospitalizations and 36,000 deaths from flu-related complications. In this study, we characterized ...
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Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets
... C urrently licensed influenza virus vaccines are proven to reduce the burden of influenza virus infections. However, epidemics of influenza still occur every year, resulting in significant morbid- ity (1) and mortality ...
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In Vitro Assessment of Attachment Pattern and Replication Efficiency of H5N1 Influenza A Viruses with Altered Receptor Specificity
... a ferret model, since it has been shown that ferrets have one of the most similar attachment patterns to humans with respect to both avian and human influenza A viruses ...
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The Effect of Irradiation with Different Wave lengths on the Oestrous Cycle of the Ferret, with Remarks on the Factors Controlling Sexual Periodicity
... It is concluded that in the ferret and so probably in many other animals light radiations of particular wave-length and sufficient intensity are an efficient cause of reproductive activi[r] ...
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Validation of the 3-steps complete in vitro method for ruminant feedstuffs intestinal digestibility
... Hvelplund, T., Digestibility of rumen microbial protein and undegraded dietary protein estimated in the small intestine of sheep and by in sacco procedure, Acta Agric. Ferret, A., [r] ...
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Sequencing, Annotation, and Characterization of the Influenza Ferret Infectome
... biphasic model of immune responses in ferrets in- fected with pdmH1N1 that featured an early activation of the in- nate immune response that is superseded upon activation of the adaptive immune response in a later ...
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Productive Replication and Evolution of HIV-1 in Ferret Cells
... animal model for HIV-1 has not been forthcoming, with the principal obstacles being species-specific restriction mechanisms and deficits in HIV-1 dependency ...(domesticated ferret) primary cells and cell ...
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Remodeling of inhibitory synaptic connections in developing ferret visual cortex
... in ferret visual cortex indicate that they are present throughout the period examined in our studies [31,32], and anatomical studies of nonpyramidal neurons in the cat indicate that extensive axonal arbors are ...
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Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle
... Drug-induced triggered arrhythmias in heart muscle involve oscillations of membrane potential known as delayed or early afterdepolarizations DADs or EADs.. We examined the mechanism of D[r] ...
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