finger domain
The RING Finger Domain of Varicella-Zoster Virus ORF61p Has E3 Ubiquitin Ligase Activity That Is Essential for Efficient Autoubiquitination and Dispersion of Sp100-Containing Nuclear Bodies
... asterisk identifies the Cys19Gly mutation that disrupts the RING finger domain to generate ORF61RFp. (B) 293A cells were mock transformed or transformed with pCK-flag-ORF61 or pCK-flag-ORF61RF. After 48 h, ...
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COMPUTATIONAL ANALYSIS OF MUTATIONS IN REALLY INTERESTING NEW GENE FINGER DOMAIN AND BRCA1 C TERMINUS DOMAIN OF BREAST CANCER SUSCEPTIBILITY GENE
... As the majority of disease-causing mutations affect protein stability and affinity, we analyzed the BRCA1 protein mutations and compared them with the native protein to evaluate stability changes. A total of 10 SNPs were ...
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Zinc Finger Domain of Murine Leukemia Virus Nucleocapsid Protein Enhances the Rate of Viral DNA Synthesis in Vivo
... zinc finger domain or CCHC motif) and numerous basic amino acids and is tightly associated with the genomic RNA dimer in the virion core ...zinc finger is indispensable for specific RNA recognition ...
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The N terminus zinc finger domain of Xenopus SIP1 is important for neural induction, but not for suppression of Xbra expression
... 4 domain-deletion mutants of XSIP1. Deletion of the N-terminus zinc finger domain suppressed neural induction and BMP inhibition, but these were not affected by deletion of the other domains (the ...
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The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain
... The MDM2 protein was initially tested to deter- mine if it was capable of binding to RNA because of the presence of the central zinc finger and C-terminal RING finger domains in the prot[r] ...
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PHD-finger domain protein 5A functions as a novel oncoprotein in lung adenocarcinoma
... Moreover, functional studies demonstrated that PHF5A knockdown not only resulted in reduced cell proliferation, increased cell apoptosis, and cell cycle arrest, but also suppressed migra[r] ...
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C-Cbl negatively regulates TRAF6-mediated NF-κB activation by promoting K48-linked polyubiquitination of TRAF6
... RING finger-dependent manner ...SH2 domain, RING finger domain, proline-rich domain, and a leucine zipper [13, ...RING finger domain is the ability to mediate ...
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A novel RING finger in the C-terminal domain of the coatomer protein α-COP
... a Domain diagram of S. cerevisiae α -COP. Domain boundaries were obtained by referring to CDD (Additional file ...RING finger domain is indicated in ...RING domain from α -COP homologs. ...
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Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain
... p1 domain, which gives rise to V1 ...p1 domain and animals lacking prdm12 function demonstrate a defective touch-evoked escape response [22, 23], suggesting that the V1 interneurons are ...p1 domain ...
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The Drosophila melanogaster suppressor of Hairy-wing zinc finger protein has minimal effects on gene expression in Saccharomyces cerevisiae.
... SETT, unpublished results). In all experiments both the full-length SUHW and zinc finger domain shifted the topoisomer distribution peak to the same direction and extent as [r] ...
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ZNF300 tight self-regulation and functioning through DNA methylation and histone acetylation
... zinc finger domain-encoding regions in regulating the expression of KRAB-ZFP ...zinc finger domain-encoding regions from different KRAB-ZFP genes acted as repres- sive cis-elements ...zinc ...
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Original Article Low nuclear zinc finger and BTB domain containing 7A expression is an independent prognostic factor for recurrence-free survival in invasive ductal carcinoma of the breast
... Zinc finger and BTB domain containing 7A (ZBTB7A; also known as factor that binds to inducer of short transcripts protein 1, Pokemon, leukemia/lymphoma-related factor, and osteo- clast-derived zinc ...
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Diastereomeric Recognition of 5',8-cyclo-2'-deoxyadenosine Lesions by Human poly(ADP-ribose) Polymerase 1 in Biomimetic Model
... zinc finger domain of PARP1 in mediating its binding to the undamaged and damaged substrates with cdA lesions, we examined the binding of mouse PARP2 to the ...zinc finger, the difference of the ...
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RING Finger Z Protein of Lymphocytic Choriomeningitis Virus (LCMV) Inhibits Transcription and RNA Replication of an LCMV S-Segment Minigenome
... RING finger domain of the type RING HC (C1-X2- C2-X9-C3-X2-H1-X2-C4-X2-C5-X10-C6-X2-C7) ...RING finger domain have been shown to unfold the RING and to affect the function of these proteins ...
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Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea
... wHTH domain, whereas the C-terminal domain is a distinct Zn-finger domain shared with most eukaryotic RPC34 ...wHTH domain (with all structural elements of wHTH, namely, three α-helices ...
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IRF3 Inhibition by Rotavirus NSP1 Is Host Cell and Virus Strain Dependent but Independent of NSP1 Proteasomal Degradation
... RING finger domain of NSP1 reportedly result in increased NSP1 expression and a reduced IRF3 degradation function ...RING finger, a structurally important domain, also caused disruption of ...
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A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation
... cDNAs from a pooled age-matched control brains as a "driver" [10]. BLAST searches revealed that this fragment showed a significant sequence identity with human genomic clone RP11-127P7 on chromosome 6 (GenBank ...
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A Selective Screen Reveals Discrete Functional Domains in Drosophila Nanos
... zinc finger domain for all aspects of nanos quence, nanos mutant females produce very few ...nor domain constitutes a separate domain required for the targets for Nanos during germ-line ...
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Glasmacher, Elke (2010): Roquin binds to ICOS mRNA for P body-dependent and miRNA-independent posttranscriptional gene silencing. Dissertation, LMU München: Fakultät für Biologie
... the full length Roquin and MNAB proteins from our adenoviral vectors. Interestingly, cDNA-based MNAB expression not only resulted in the full-length protein, but also in a shortened version, which was detected by ...
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Structure of Arabidopsis HISTONE DEACETYLASE15
... The zinc finger domain enhances HDA15HD dimerization and enzymatic. 796[r] ...
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