first-pass metabolism
“Formulation and Evaluation of Thermoreversible In-Situ Nasal Gel of Rizatriptan Benzoate and Caffiene” by Amit Jadhav, Abhishek Sagade, Sudarshan Jagtap, Gaurav Shinde, Dr.G.Chhabra, Mahesh Shinde, India.
... Rizatriptan benzoate undergo hepatic first pass metabolism. Aim of present research work is to overcome hepatic first pass metabolism by formulating in-situ nasal gel along with ...
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Parenteral systems for statin delivery: a review
... the first time in 1947 as a buccal drug delivery ...extensive first-pass metabolism, possess short half-lives of elimination, require continuous and controlled deliv- ery, and have low aqueous ...
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Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation
... The investigated drug (NF) was successfully incorporated into the core of the developed vesicles. The formulated niosomes significantly improved NF permeation across nasal mucosa and prolonged the drug release rate. ...
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Formulation, characterization and Evaluation of Transdermal Film Containing Naproxen
... ability to avoid first-pass metabolism and also to circumvent the hostile environment of the gastrointestinal tract. 5 In the present study an attempt was made to design the Transdermal patches of ...
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LUNG TARGETING OF ANTITUBERCULAR DRUGS BY MICROSPHERE: A REVIEW
... of first-pass metabolism, direct delivery to the site of action for the treatment of respiratory diseases, and the availability of a huge surface area for local drug action and systemic absorption of ...
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“Transdermal Drug Delivery System for Controlled Drug Administration - A Review” by Shilpa Sivashankar, Diksha Gupta, Minika Chetry, Nilakshi Mazumder, India.
... Transdermal drug delivery system serves to be an efficient way for drug administration to the target site in a very controlled manner. Recent advances in technology have proved transdermal drug delivery as one the most ...
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ADVANTAGEOUS NASAL DRUG DELIVERY SYSTEM: A REVIEW
... by first pass effect in the ...hepatic first pass metabolism is absent, Rapid drug absorption and quick onset of action can be achieved, bioavailability of larger drug molecules can be ...
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EXPLORING THE TASTE MASKING EFFECT OF ION EXCHANGE RESINS IN ORODISPERSIBLE TABLETS OF LEVOCETIRIZINE HYDROCHLORIDE
... The concept of formulating Orodispersible tablets containing Levocetirizine hydrochloride offers a suitable, practical approach to achieve fast release of the drug. Absorption of these tablets takes place direct into the ...
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FORMULATION AND CHARACTERIZATION OF TOPICAL NANO EMULGEL OF TERBINAFINE
... The principle object of the present experimental work was to make a most effective topical preparation for avoid the first pass metabolism of terbinafine in the treatment of antifungal infections ...
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MODELING THE ORAL CAVITY WITH MUCOADHESIVE DRUG DELIVERY SYSTEMS - A POTENTIAL ALTERNATIVE TO CONVENTIONAL THERAPY
... Over the last few decades, research in Mucoadhesive drug delivery becoming more popular because it does have significant advantages like avoidance of first pass metabolism, pre-systemic elimination ...
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Formulation of Buccal Strips using PEG 400 and Honey as a Plasticizers
... Buccal films show rapid dissolution along with it also used to avoid first pass metabolism of the drug entrapped in the buccal film formulation because they get absorbed through buccal mucosa .The ...
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Liposomal delivery systems for intestinal lymphatic drug transport
... the first-pass metabolism in the liver ...drugs pass through the small in- testine and enter the portal vein or intestinal lymphatic system ...
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Gastrointestinal delivery of propofol from fospropofol: its bioavailability and activity in rodents and human volunteers
... liver metabolism likely limits oral bioavailability of propofol as oil in emul- ...escaping first pass metabolism by the gut wall (fa), liver (fh) and lung (fl) were calculated using propofol ...
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The Effect of the Dynamic Interplay of P-glycoprotein and Cytochrome P450 3A on the Portal Bioavailability of Dual Substrates
... must first be absorbed across the intestinal ...intestinal first-pass metabolism (Benet, 1996; Paine et ...and metabolism, or interactions of these two barrier mechanisms during the ...
207
BUCCAL PATCHES- A Review
... Buccal drug delivery is useful for the drugs that undergo first pass metabolism and GI degradation. In this drug delivery system the formulation keeps in contact with the mucosal surface resulting in ...
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“FORMULATION AND EVALUATION ASPECTS OF TRANSDERMAL DRUG DELIVERY SYSTEM – A REVIEW” by Dipen M. Patel*, Kavitha K, India.
... hepatic first pass metabolism and tendency to produce rapid blood level spikes (Both high and low), leading to a need for high and/or frequent dosing, which can be both cost prohibitive and ...
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“Design and Evaluation of Mucoadhesive Buccal Patch of Ramipril” by Anjana Anil, Preethi Sudheer, India.
... hepatic first pass metabolism and improve the bioavailability of ...hepatic first pass metabolism and to release the drug in a sustained ...
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Formulation and evaluation of dabigatran fast dissolving tablets by using polyplasdone xl-10 and primellose
... Dabigatran is an oral anticoagulant drug requiring rapid onset of action to exert desired pharmacological effect. It is a lipophilic (BCS Class-II) with little/no aqueous solubility, its absorption is dissolution rate ...
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First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates
... low first-pass metabolism was observed with 92% of midazolam entering the systemic circulation in a typical preterm neonate of ...the first 4 hours post- dose compared to the 30-minute ...
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Increasing Contrast Agent Concentration Improves Enhancement in First Pass CT Perfusion
... terial bolus remains in the intravascular space resulting in tis- sue enhancement proportional to the amount of iodine in the vessel. The signal intensity has to rise reliably above the base- line noise to perform a ...
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