focal adhesions
Focal Adhesions, Contractility, and Signaling.pdf
... Csk is an important regulator of the src family kinases. It inhibits their activity by phosphorylating the C-terminal tyrosine residue. This C-terminal phospho- tyrosine then participates in an intramolecular association ...
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PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus Localize to Focal Adhesions and Are Antiphagocytic in Insect Immune Cells
... Viruses in the family Polydnaviridae are symbiotically associated with parasitoid wasps. Wasps inject polydnaviruses (PDVs) when laying an egg into their insect host, and expression of viral gene products causes several ...
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A novel non-sulphamoylated 2-methoxyestradiol derivative causes detachment of breast cancer cells by rapid disassembly of focal adhesions
... of focal adhesions and the actin cytoskeleton by confocal microscopy shows that focal adhesions rapidly disassemble after EE-15-one exposure while the actin stress fibres become severed and ...
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Focal Adhesions Transmembrane junctions between the extracellular matrix and the cytoskeleton.pdf
... affect focal adhesions in receptive ...as focal adhesions, as judged by staining for a-actinin (Schlessinger & Geiger ...offocal adhesions (Herman & Pledger 1985). Surprisingly, ...
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Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration
... Previous studies provide some insights into how Synpo2 could affect cancer cell migration responses. We recently determined that all five isoforms of Synpo2 induce formation of, and co-localize with, morphologically and ...
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Interleukin-8 Regulates Endothelial Permeability by Down-regulation of Tight Junction but not Dependent on Integrins Induced Focal Adhesions
... Interleukin-8 (IL-8) is a common inflammatory factor, which involves in various non-specific pathological processes of inflammation. It has been found that increased endothelial permeability accompanied with high ...
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Loss of focal adhesions in glia disrupts both glial and photoreceptor axon migration in the Drosophila visual system
... The PG migrate between the CG and the basal ECM (Silies et al., 2007), and loss of focal adhesions led to a disruption in PG migration, suggesting that integrin complexes on one or both surfaces play a role ...
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GFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions
... Focal adhesions are tightly regulated during cell migration, and GFAP has been linked to in vitro migration by others [4, 43]. To check for changes in cell motility, we analyzed single cell motility and ...
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Cytomegalovirus Destruction of Focal Adhesions Revealed in a High-Throughput Western Blot Analysis of Cellular Protein Expression
... lator of muscle differentiation (27). However, Hic-5 also local- izes to focal adhesions, is subject to tyrosine phosphorylation, and is similar to paxillin in its primary structure (22, 38, 51). Hic-5 ...
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Focal adhesions A Nexus for intracellular signaling.pdf
... some focal adhesion proteins are actively targeted to and from focal adhe- sions via a vesicle trafficking ...affects focal adhesion ...to focal adhesions ...to focal ...
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Agonist stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c Src
... of focal adhesion proteins and the role of c-Src in VSMC cytoskeletal ...to focal adhesions upon integrin-mediated cell ...regulating focal adhe- sions in ...
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Automatic segmentation of focal adhesions from mouse embryonic fibroblasts
... of focal adhesions is initiated by the anchoring of F-actin to the intracellular domain of integrins via protein adaptors paxillin, talin, and ...site. Focal adhesion formation and disassembly was ...
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C3G forms complexes with Bcr-Abl and p38α MAPK at the focal adhesions in chronic myeloid leukemia cells: implication in the regulation of leukemic cell adhesion
... Our data indicate that C3G plays a relevant role in the regulation of adhesion in CML cells by interacting with Bcr-Abl, p38αMAPK, Cbl, p130Cas, Abi1, FAK and paxillin at the focal adhesions. It is likely ...
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Lipid rafts remain stable even after ionizing radiation induced disintegration of β1 integrin containing focal adhesions
... Taken together the data show that not only the mem- brane mobility but also the organization of lipids into rafts are remarkably affected by the cell culture condi- tion. This suggests even more that PM located signaling ...
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Biomimetic Poly(ester amide) Biomaterials for Vascular Tissue Engineering
... formed focal adhesions on all 2D PEA surfaces as illustrated by vinculin immunofluorescence, yet smooth muscle α -actin (SMαA) expression was not abundant, suggesting that the HCASMCs had adopted a ...
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Control of cAMP signalling in the cellular migration of pancreatic ductal adenocarcinoma
... to focal adhesions occurs through the C-terminal focal-adhesion targeting (FAT) domain (Mitra et ...Another focal adhesion associated kinase, Src, binds to and phosphorylates FAK resulting in ...
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Hippo signaling: growth control and beyond
... Although there is evidence that the Fat1 cadherin plays a role in regulating focal adhesions and actin dynamics Ishiuchi et al., 2009; Moeller et al., 2004; Tanoue and Takeichi, 2004, an[r] ...
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HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures
... Hectd1 Gt(RRC200) ) mouse of the E3 ubiquitin ligase for inhibin B receptor (Hectd1). Detailed examination of cell motion on MEF cells demonstrated that loss of Hectd1 resulted in accelerated cell spreading and migration ...
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Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells
... and focal adhesion expres- sion are correlated with the progression to an invasive cell phenotype ...of focal adhesions in highly metastatic cells is likely to be located in the lamellipodia, which ...
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β2 adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion
... from focal adhesions [5, 6], resulting in a shift to invadopodia-mediated invasion, which favors tumor cell movement through the sur- rounding three-dimensional extracellular matrix and leads to tumor cell ...
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