G-quadruplex DNA
Electrochemical and Spectroscopic Study on the Interaction Between G-Quadruplex DNA and (R)-/(S)-2-(5-Fluorouracil-1-Acetyl) Amido-1, 5-Dimethyl Glutarate
... duplex DNA [8–10]. Ideal G-quadruplex DNA ligands, therefore, should bind selectively to their target and have few interactions with duplex ...regarding G-quadruplex DNA ...
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← Return to Article Details INDUCTION OF C-MYC G-QUADRUPLEX DNA AND CYTOTOXICITY OF A CALIX[4]ARENE-CONTAINING BINUCLEAR RUTHENIUM(II) COMPLEX
... c-myc G-quadruplex has been firstly investigated by the electronic spectra, as shown in ...Pu27 DNA but also c-myc Pu22 DNA, obvious hypochromism and red shift were ...[c-myc ...
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Selective interactions with various G-quadruplex DNA forming sequences by berberine and palmatine analogues
... stabilize G-quadruplex DNA which significantly improves their inhibitory activity on telomerase [28]; the second one is that the specific presence of amino acid chains on quinolidine structures ...
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Does G-quadruplex DNA have a functional role in regulation of the transcriptome?
... identify DNA segments that actually adopt non-B DNA conformations in vivo, I have identified sequences with a high probability of secondary structure ...in G-Quadruplex has been ...of ...
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Mirror image dependence : targeting enantiomeric G quadruplex DNA using triplex metallohelices
... Abstract: DNA chirality is the fundamental issue for design of DNA- targeted chiral drugs and DNA-based chiral ...of DNA, it is still not clear how enantiomeric compounds to recognize ...
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Chiral metallohelices enantioselectively target hybrid human telomeric G quadruplex DNA
... different DNA structures and showed admirable chiral selectivity ...telomeric G-quadruplex the right-handed helix selectively stabilized antiparallel G-quadruplex, whilst the ...
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Development of a series of bis triazoles as G quadruplex ligands
... standard G-quadruplex DNA ...parallel G-quadruplex DNA template, and the set of ligands 44–53 bound to the 3 0 -side of G4-DNA in the best pose for their common ...of ...
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Qualitative SERS analysis of G-quadruplex DNAs using selective stabilising ligands
... rich DNA sequences can spontaneously fold into G-quadruplex DNA structures in vitro and more recent studies have shown that quadruplexes have certain functions in ...2 G-quadruplexes ...
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Quinazoline derivative QPB-15e stabilizes the c-myc promoter G-quadruplex and inhibits tumor growth in vivo
... FRET-melting was performed on a real-time PCR apparatus (Roche LigntCycler) as previously described [20]. Briefly, the fluorescent-labeled oligonucleotide FPu18T (5ʹ - FAM–AGGGTGGGGAGGGTGGGG–TAMRA - 3ʹ) was denatured. ...
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Development of g-quadruplex stabilizers as anticancer drug therapy and selective agonists of the human oxytocin receptor as a therapeutic tool for neuropsychiatric disorders
... Small-molecule G-quadruplex-binding ligands have been explored as an approach towards telomerase ...stabilizing G-quadruplexes, G-quadruplex-binding ligands have the potential to affect ...
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A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region
... the G-quadruplex in the telomeric region may result in the dissociation of telomere binding protein and telomere uncapping [36], we next investigated the effects of Ber8 on the dissociation of ...
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QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs
... where G-quadruplexes may be formed, rather than specific ...proximate G-quadruplexes, are called regions with ‘G4 potential, ’ or G4P ...of G-tracts, the higher predicted stability [54], or other ...
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RHPS4 G quadruplex ligand induces anti proliferative effects in brain tumor cells
... To assess the effects of G4 stabilization directly at the telomere substrate, we introduced RHPS4 directly into cell-free TRAP assays using drug-treated protein/RNA lysates in order to discriminate whether RHPS4-mediated ...
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An Aptamer-Based Biosensor for the Azole Class of Antifungal Drugs
... a DNA aptamer recognizing azole class antifungal ...unique G-quadruplex structure that was essential and specific for binding to the azole antifungal ...
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Telomere damage induced by the G quadruplex ligand RHPS4 has an antitumor effect
... G4 DNA is perceived as damage because it prevents t-loop formation and/or blocks the progression of the replication fork through telomeric ...G4 DNA by RHPS4 through several means, including the formation ...
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Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
... duplex DNA typically produce their cytotoxic effect by interfering with transcription or with the correct function of DNA topoisomer- ases or other enzymes involved in DNA ...duplex DNA ...
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Structural transformation induced by locked nucleic acid or 2′–O-methyl nucleic acid site-specific modifications on thrombin binding aptamer
... guanine-rich DNA and RNA sequences may fold into G-quadruplex structures through Hoogsteen hydrogen bonds [5-7], which may be involved in human biology and diseases ...or quadruplex structures ...
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Abolishing HIV 1 infectivity using a polypurine tract specific G quadruplex forming oligonucleotide
... ODN G, is identical to ODN A in the passenger strand with some nucleotide exchanges in the antisense strand to avoid binding to the viral RNA genome (see ...
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“Synthesis of New Poly Amide linked Heterocyclesas G-quadruplex Stabilizing Agents” by Kawkab Saour, Dunya Lafta, Iraq.
... the G-quadruplex interaction of Compounds (6–11) was initially carried out using a FRET- based melting assay 18 using fluorescence tagged Seq-3 obtained from (Eurogentec, UK, see practical section for ...
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Synapsable quadruplex mediated fibers
... synapsable DNA was heated to 90°C, which should not affect the G-quadruplex structure but should affect the duplex re- ...synapsable DNA fiber formation was improved or resulted in ...
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