GABAA receptor
The influence of membrane cholesterol on the rat GABAA receptor
... the GABAa receptor subunits by analogy to that of the M2 domain in the AChR is tliought to line the ion channel ...the GABAa receptor and the and Pz subunits of the nAChR have an invariant ...
165
Influence of membrane cholesterol on neurosteroid modulation of BNZ/GABAA receptor
... The GABAa receptor contains sites of action for several distinct classes of drugs, including G ABA agonists, benzodiazepines, barbiturates and neurosteroids (Olsen, ...GABA^ receptor is derived from ...
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Cyfip1 haploinsufficiency does not alter GABAA receptor δ subunit expression and tonic inhibition in dentate gyrus PV+ interneurons and granule cells
... Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor ␦-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV⫹ Interneurons and Granule Cells Simon Trent,1 Jeremy Hall,1.. Neuros[r] ...
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Structure and function of the GabaA receptor
... nACh receptor family (Figure ...nACh receptor from muscle in which the L9' residue in the y subunit was changed to serine (L9'S) report changes in channel open time but no change in conductance (Filatov and ...
178
Structure Guided Modeling and Binding Studies of GABAA Receptor Subunit Beta 3
... distinct receptor subtypes are preferentially expressed in specific regions and neuronal populations and they exhibit different sensitivities to modulators including neurosteroids, benzodiazepines, ethanol and ...
5
Effects of Nourishing “Yin” Removing “Fire” Chinese Herb Mixture on the Differential Expression of GABAA Receptor α Subunits in Hypothalamus of Precocious Puberty Female Rats
... lating precocious puberty. It was reported that Chinese herb mixture might regulate the abnormal function of HPGA in precocious puberty through down-regulate the hypothalamus kiss-1/PGR54 expression, and inhibit GnRH ...
10
Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation
... study tended to increase as hydrocarbon chains length- ened within any functional group. This is consistent with the Meyer-Overton prediction of increased anesthetic po- tency as a function of increasing hydrophobicity ...
13
Effects of common anesthetic agents on [18F]flumazenil binding to the GABAA receptor
... While uptake in the ket/dex anesthetized mice was very similar between the ex vivo and in vivo experiments, the uptake under isoflurane anesthesia was much lower when mea- sured ex vivo [r] ...
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GABAA Receptor Modulation by Compounds Isolated from Salvia triloba L
... GABA/benzodiazepine receptor but it had no effect on the binding of muscimol, diazepam or flunitrazepam, suggesting that the site of action of carnosol to be directly on the chloride channel ...
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Differential Effect of Unilateral Amygdalar GABAA Receptor Agonist Injection on Low and High Anxiety Rats
... In the work, we find that statistically significant differences in the behavior of high-anxiety rats are observed only upon left-side administration of the agent. There are literature data stating that right-side, but ...
10
High and Low Rearing Rats Differ in the Brain Excitability Controlled by the Allosteric Benzodiazepine Site in the GABAA Receptor
... Of all the convulsant drugs tested only DMCM, a ben- zodiazepine inverse agonist [15,19,36,37], induced dif- ferential clonic convulsions between the HR and LR groups. The lower convulsant dose 50% obtained in the LR ...
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IN SILICO MOLECULAR DOCKING ANALYSIS OF ISOLATED HOMOISOFLAVANONES FROM BULBS OF LEDABOURIA REVOLUTA AS GABAA RECEPTOR INHIBITORS
... involving GABA can be a better mechanism for identification of novel antiepileptic drugs. In this report, screening of novel isolated homoisoflavanones from bulbs of Ledabouria revoluta against human GABRB3 active site ...
7
Taurine activates glycine and GABAA receptor currents in anoxia tolerant painted turtle pyramidal neurons
... glutamatergic receptor currents are arrested: whole-cell α -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptor currents are reduced by about 50% after 40 min ...
14
Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents
... A , Representative traces showing the tonic GABAAR currents in the projection neurons (PNs) of lateral amygdala (LA) from control mice (upper) and mice experiencing 10 days of recovery f[r] ...
14
The vertebrate neuronal gamma aminobutyric acid (GABAa) receptor and its modulation: a patch clamp study
... Recently two subtypes of the central BZ receptor have been proposed. The trlazolopyrldazlne anxiolytics CL 218872 and some ;0-carbollne~3-carboxylate esters Inhibit benzodiazepine binding In a blphaslc manner ...
348
Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal
... glycation end products [AGEs]), generation of reactive oxygen spe- cies, and cell death (8, 12). Despite the well-known cellular effects of MG, there is no known mechanism linking MG to anxiety. In this study, we used ...
11
Photo antagonism of the GABAA receptor
... modified receptor structure to incorporate an epitope that is either recognized by selective antisera 48 , or is an inherent fluorophore 49 ...the receptor to be coupled to a quantum dot 50,51 or carry a ...
14
Studies on the phosphorylation of GABAA receptor β subunits
... receptors. Receptor intracellular domains have been expressed as soluble glutathione-S-transferase (GST) fusion proteins in Escherichia coli which allows their purification in large quantities (Smith and Johnson, ...
198
Molecular mechanisms of GABAA receptor anchoring and trafficking
... I w ould like to thank M oss for his supervision during my tim e as a graduate student. He has provided a w onderful environm ent to w ork in and balanced su pervision that have fo stered my en th u siasm for N eu ro ...
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Antibodies to GABAA receptor α1 and γ2 subunitsClinical and serologic characterization
... manuscript. A. Jacob has received honoraria as a speaker on neuromy- elitis optica from Biogen Idec and Chugai and is on clinical trial advi- sory boards for Chugai and Alexion Pharmaceuticals. S. Irani is a coapplicant ...
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