Gap Junction
Pore-Lining Residues and Intracellular Magnesium Concentration Influence Connexin50 Gap Junction Unitary Channel Conductance
... Gap junction (GJ) channels are fundamental to synchronizing physiological activities in multicellular organisms. These intercellular channels form a communication network by directly linking cytoplasm ...
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Transverse propagation in an expanded PSpice model for cardiac muscle with gap-junction ion channels
... Transverse propagation was previously found to occur in a two-dimensional model of cardiac muscle using the PSpice software program for electronic circuit design and analysis [16-19]. Longitudinal propagation within each ...
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Intracerebroventricular Injection of Lipopolysaccharide Increases Gene Expression of Connexin32 Gap Junction in Rat Hippocampus
... 2008). Gap junctions facilitate ionic homeostasis and synchro- nization of action potential in the nervous system (Sohl et ...that gap-junctional communication is associ- ated with the spread of cell death ...
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Carbenoxolone, a Gap Junction Blocker, Enhances Antinociceptive Effects of Morphine in Formalin Test In Mice
... a gap junction blocker, using the formalin test as a model of ...if gap junction channels are important in pain facilitation and/or propagation, carbenoxolone will reduce nociception, which ...
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Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein
... containing conserved transmembrane and extracellular domains, but unique cytoplasmic regions that may confer connexin-specific physiological properties. We used polymerase chain reaction amplification and cDNA library ...
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smedinx 11 is a planarian stem cell gap junction gene required for regeneration and homeostasis
... Gap junction-permeable signals have been implicated in embryonic morphogenesis and neoplasm (Bruzzone et ...Invertebrate gap junctions are composed of proteins from the innexin family, whereas ...
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Simvastatin sodium salt and fluvastatin interact with human gap junction gamma 3 protein
... gap junction channels comprising connexins are known to undergo remodeling in disease [116] and hetero-oligomerisation of connexins is a recognized phenomenon [117,118] raising the possibility that ...
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7-Ketocholesterol modulates intercellular communication through gap-junction in bovine lens epithelial cells
... through gap junctions formed by Cx46/ ...into gap junction [16-18] it is conceivable that the effect of 7-keto on GJIC may be caused by a mechanism involv- ing cytoskeleton ...
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Slow conduction and gap junction remodeling in murine ventricle after chronic alcohol ingestion
... disturbed gap junction distribution in the left myocardium of mice with long-term alcohol ...Cx43 gap junctions, as shown in the below histograms, each of which represents more than 80 randomly ...
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Emerging roles of gap junction proteins connexins in cancer metastasis, chemoresistance and clinical application
... with gap junction inhibitor 18-α-gly- cyrrhetinic acid (18αGA) reduced multiple myeloma cell adhesion to BMSCs, and partially abrogated their migration ability enhanced by co-culturing with BMSCs ...
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Structure and function of gap junction proteins: role of gap junction proteins in embryonic heart development
... between gap junction intercellular commu- nication and teratogenicity - effects on embryogenesis The effect of GJs in embryonic development is quite well un- derstood and studied, though the mechanisms ...
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Continuous Time Markov Chain Models of Voltage Gating of Gap Junction Channels
... Connexins (Cxs) is large family of integral membrane proteins that provide a direct pathway for electrical and metabolic signaling between cells [2]. 21 Cx isoforms in humans [14] form gap junction (GJ) ...
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Macrophages facilitate post myocardial infarction arrhythmias: roles of gap junction and KCa3.1
... monocytes is significantly higher in patients with post-MI arrhythmias than healthy controls and MI patients without arrhythmias (p<0.001, Figure 1). The pro-inflammatory monocyte subsets are the direct precursors of ...
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MicroRNA-23a Participates in Estrogen Deficiency Induced Gap Junction Remodeling of Rats by Targeting GJA1
... that gap junctions in NC group displayed very close cell-to-cell appositions, and however, overexpression of miR-23a prevented gap junction development in NRVCs indicated by enlarged cell-to-cell ...
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Nitric oxide, PKC-ε, and connexin43 are crucial for ischemic preconditioning-induced chemical gap junction uncoupling
... Gap junctions (GJs), which are composed of two hexameric connexins, are specialized membrane domains in adjacent cells that allow direct exchange of molecules smaller than 1kDa (chemical coupling) and fast ...
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Visfatin reduces gap junction mediated cell to cell communication in proximal tubule derived epithelial cells
... suggesting gap junction-mediated intercellular communication (Fig ...of gap junction-mediated intercellular communication in response to visfatin is TGF-β1 dependent (Fig ...
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Mouse Hepatitis Virus Infection Remodels Connexin43-Mediated Gap Junction Intercellular Communication In Vitro and In Vivo
... Results of the current studies provide important insights into the virus-induced alteration of GJIC between astrocytes. Cx43 not only is involved in maintaining homeostasis among astrocytes but also is equally important ...
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Effect of transverse gap-junction channels on transverse propagation in an enlarged PSpice model of cardiac muscle
... transverse gap junctions were positioned at the ends of each chain, so that propagation occurred in a zigzag ...one gap junction each, whereas chains B-I had two transverse junc- tions, one at each ...
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Cell cycle dependent regulation of gap junction coupling and apoptosis in GFSHR 17 granulosa cells
... inhibits gap junc- tion coupling [10] (Figure ...the gap junc- tion coupling in the system is also shown by the experi- ments with HeLa cells which do not express gap juncti- ...on gap junc- ...
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Engineered connexin40 variants increased docking and function of heterotypic connexin40/connexin43 gap junction channels
... Gap junction (GJ) channels provide low resistance passage for rapid action potential propagation in the heart. Both connexin40 (Cx40) and Cx43 are abundantly expressed in and frequently co-localized between ...
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