GDF-15
NF κB regulates GDF 15 to suppress macrophage surveillance during early tumor development
... higher GDF-15 expression (Supple- mental Figure ...elevated GDF-15 expres- sion have a poorer ...ed GDF-15 have a worse outcome compared with those with lower expression of ...
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Original Article GDF-15 promotes proliferation of vascular smooth muscle cells through MAPK-activated protein kinase pathways
... factor 15 (GDF-15) is a multifunctional member of the TGF-b ...whether GDF-15 also participates into the VSMCs proliferation is still lack of systemic ...ox-LDL-induced ...
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EFFECT OF THE TRIAZOLE ANALOG TAN ON GDF-15 EXPRESSION IN HUMAN COLORECTAL CANCER HCT116 CELL LINE
... GDF_ 15 is engaged in controlling apoptosis & inflammatory response during disease & tissue injury ...Normally, GDF-15 expressed in significant amounts by the placenta only ; although it is ...
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GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease
... by GDF-15 tertiles, using t -test or ...between GDF-15 ter- tiles and CAC burden categories by two ...with GDF tertiles, then adjusting for baseline HEART score, then further adjusting ...
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Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood
... vasculature. GDF-15 is a divergent TGF-beta superfamily member, first cloned from acti- vated macrophages [41] and named Macrophage inhibi- tory cytokine-1 ...[42–45]. GDF-15 plays key ...
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GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells
... for GDF-15 in human normal lung tissue with almost no expression in the airways like bronchial and alveolar epithelial ...[18], GDF-15 was strongly expressed in alveolar macrophages which ...
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The Effect of Resistance Training on Serum Levels of NT-proBNP, GDF-15, and Markers of Cardiac Damage in the Elderly Males
... Totally, 15%-25% of CK in heart cells is as MB (CK-MB), while it is about 3% in skeletal ...and GDF-15 should be considered in order to more accurately assess AMI and provide effective therapeutic ...
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GDF -15 and Severity Scores in Sickle Cell Disease Patients Attending Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria
... of GDF-15, which is an anti-inflammatory cytokine, to be increased in SCD compared to controls and to correlate negatively with disease ...Natural GDF-15 mimetic substances such as polyphenols ...
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GDF-15 protects from macrophage accumulation in a mousemodel of advanced atherosclerosis
... There are several limitations to our study. Investigat- ing atherosclerotic lesions in LDLr −/− mice is mostly done in the aortic root, which is not a typical lesion lo- cation. It is known as a model of early stages in ...
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Identification of novel host biomarkers in plasma as candidates for the immunodiagnosis of tuberculosis disease and monitoring of tuberculosis treatment response
... III, GDF-15, NCAM, HCC1, MIP-4 and recently identified markers I-309, MIG, Apo A-1, transthyretin and CFH, showed potential in the diagnosis of TB disease, regardless of HIV infection status as determined ...
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Plasma levels of heart failure biomarkers are primarily a reflection of extracardiac production
... Figure 3. Cardiac function, remodeling and biomarker expression 4 and 8 weeks after TAC. (A) Representative MRI images of short axis in systole and diastole (upper panel). EF (%) 8 weeks after tLAD and pLAD, as ...
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Growth differentiation factor 15 and early prognosis after out-of-hospital cardiac arrest
... superfamily. GDF- 15 is weakly expressed in tissues, including the central nervous system [21], under normal ...of GDF-15 have been identified as an inflammatory biomarker with prognostic ...
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Potential relation between soluble growth differentiation factor-15 and testosterone deficiency in male patients with coronary artery disease
... between GDF-15 and C-reaction protein in a molecular level, which facilitated improved understanding of the pivotal inflammatory pathways important in CAD ...higher GDF-15 concentration with ...
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Original Article Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer
... of GDF-15 in gastric cancer and adjacent normal tissues was detected by ...microscopy. GDF-15 gene expression and protein level were significantly reduced in the TSA treated group (75 ng/mL ...
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Determinants of growth differentiation factor 15 in patients with stable and acute coronary artery disease. A prospective observational study
... admission GDF-15 for future spon- taneous MI and death ...for GDF-15 in patients with ASC undergoing, but not in those without invasive management ...therapy, GDF-15 levels were ...
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Preoperative plasma growth differentiation factor 15 for prediction of acute kidney injury in patients undergoing cardiac surgery
... of GDF-15. In logistic regression, preoperative GDF-15, additive Euroscore, age, plasma creatinine, diabetes mellitus, and duration of cardiopulmonary bypass were independently associated with ...
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A comparison of current serum biomarkers as diagnostic indicators of mitochondrial diseases
... We used Mann-Whitney U and Kruskal-Wallis nonparametric testing to determine statistical differences between groups. We calculated the diagnostic sensitivity and the corresponding 95% confidence intervals. An unadjusted ...
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Serum Growth Differentiation Factor 15 in Patients with Ulcerative Colitis
... of GDF-15 as an erythroid regulator of hepcidin, both in humans and ...serum GDF-15 was not observed in human volunteers who received erythropoietin or in volunteers who underwent ...serum ...
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Growth differentiation factor-15 is associated with cardiovascular outcomes in patients with coronary artery disease
... that GDF-15 concentra- tions higher than 1800 ng/L were associated with an increased risk of all-cause death and MACEs in patients with established ...biomarkers, GDF-15 remained an ...
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Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo
... However, GDF-15 expression was not associated with fi bre type within the muscle nor was there an association of serum GDF-15 with fi bre ...in GDF-15 expression observed and that ...
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