Gene by Environment Interactions
Original Article Methylenetetrahydrofolate reductase gene A1298C polymorphism and gene-environment interactions are associated with carotid plaque in a south Chinese population
... MTHFR gene A1298C polymorphism in combi- nation with certain conventional risk factors and CP risk could explain the observed gene- environment ...order interactions, but cannot explain the ...
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A novel approach to simulate gene environment interactions in complex diseases
... Background: Complex diseases are multifactorial traits caused by both genetic and environmental factors. They represent the major part of human diseases and include those with largest prevalence and mortality (cancer, ...
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Toward a 3D model of human brain development for studying gene/environment interactions
... This project is supported by the NCATS grant ‘A 3D Model of Human Brain Development for Studying Gene/Environment Interactions’ (1U18TR000547). Additional work by the group referred to in the article ...
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Combinatory approaches prevent preterm birth profoundly exacerbated by gene environment interactions
... experimentally, we generated a mouse model with uterine deletion of Trp53, which exhibits approximately 50% incidence of spontaneous preterm birth due to premature decidual senescence with increased mTORC1 activity and ...
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Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease
... the environment might be even more pronounced in patients whose phenotypes are caused by the aggregation of small contributions from many genetic and non-genetic ...replicated gene-gene and ...
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Gene Environment Interactions in Asthma: Genetic and Epigenetic Effects
... candidate gene polymorphism studies, and genome-wide association studies ...a gene and the environment is a candidate interaction of both a well known gene and envi- ronmental factor in a ...
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A methodology to establish a database to study gene environment interactions for childhood asthma
... study gene-environment interactions in the context of asthma ...of gene-environment interactions to asthma heterogeneity will require a relatively large study population of ...
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Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies
... complex interactions [7]. MDR has a good sensitivity to detect gene-gene and gene- environment interactions; however, the algorithm faces two ...
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Genetic polymorphisms in PTPN22, PADI 4, and CTLA 4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene environment interactions with heavy cigarette smoking
... additive interactions between smoking, categorized as ever/never smoking and then dichotomized as ≤10 or ≥10 pack-years of smoking, for each of the ...multiplicative gene-environment ...
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Gene-by-Environment Interactions Associated with Inter-Individual Variation in Response to Chemical Exposure.
... 1.6.3 Analytical Challenges and Outlook for Environmental Health and Toxicology Current challenges faced in systems-level proteomic analysis involve seemingly mundane issues such as the mapping of identified proteins to ...
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Interpreting Coronary Artery Disease Risk Through Gene–Environment Interactions in Gene Regulation
... of gene expression in many different tissues, including three types of ...that interactions with latent environments represented by our four in vitro treatments (retinoic acid, caffeine, selenium, and ...
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Gene × gene and gene × environment interactions for complex disorders
... p-values (after correction for the increased number of tests), and by the structure of the resultant multivariate model. We do not currently have a formal test for interac- tions. In part, this is because the main goal ...
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Effect of gene environment interactions on lung function and cardiovascular disease in COPD
... investigate gene × smoking interactions on lung function, the effects of polymorphisms on serum levels of their respective proteins, and the influence of genetic variants on cardiovas- cular ...
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Gene–Environment Interactions Between Depressive Symptoms and Smoking Quantity
... Our analysis could not reveal what might be the mecha- nism underlying the GxE between the traits under investi- gation here. One could hypothesize that both smoking and depression could lead to changes in gene ...
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Gene-environment interactions and obesity: recent developments and future directions
... The 2-step approach incorporates a preliminary screening step to efficiently use all available information in the data [28]. In the first step (screening test), for each of the SNPs, a likelihood ratio test of ...
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The impact of imprecisely measured covariates on estimating gene-environment interactions
... the gene-environment ...of gene- environment interaction that can be investigated is the gene-diet interaction, where the environmental exposure is a particular dietary ...
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Assessing Gene-Environment Interactions for Common and Rare Variants with Binary Traits Using Gene-Trait Similarity Regression
... the interactions be- tween PLA2G7 and physical activity on obesity, using Cohorte Lausannoise (CoLaus) sequencing data, and a second assesses the effect modifier role of body mass index (BMI) on the as- sociation ...
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<p>Gene–Environment Interactions in Major Mental Disorders in the Czech Republic</p>
... and/or gene function sites of selected genes, the NimbleGen SeqCap Target Enrichment method enabling the speci fi c enrichment of gene regions of up to 96 samples will be ...
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Non Random Distribution of Human Orofacial Clefts in Ghana: Gene Environment Interactions
... A questionnaire was administered to case families. After identification of case fami- lies, any congenital abnormalities, apart from clefts, if they occurred, were noted. All generations of each case pedigree was ...
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Power comparison of different methods to detect genetic effects and gene environment interactions
... Although this study argues in favor of the use of the case- only design to detect a G × E interaction, it shows that if one is interested in detecting gene effect, accounting for the exposure is not necessary. Of ...
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