gene delivery
Dendrimers in gene delivery
... non-viral delivery systems, which all have distinct advantages and disadvantages ...any gene delivery system will always have to be matched with the clinical situation, the specific disease and the ...
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Recent advances in the development of gene delivery systems
... The gene delivery system based on polysacchar- ide indicates that the structure of the cationic polysac- charide has a significant role in the transfection activity for gene ...mucosal ...
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Comparison of two kinds of nanomedicine for targeted gene therapy: premodified or postmodified gene delivery systems
... vivo gene delivery and expression assays were used in an animal model to compare the gene-delivering ability of premodified and postmodified gene ...
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The development of polycationic materials for gene delivery applications
... DNA resulting in charge neutralization. PEG then orients itself to the periphery forming a micelle and internally shields the polycation/DNA complex from premature clearance via macrophage or the reticuloendothelial ...
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Supramolecular Assemblies of Peptides or Nucleopeptides for Gene Delivery
... for gene delivery should always consider reproducibility, stability, and scalability [17, ...for delivery of nucleic acids: i) Balancing of hydrophobic and hydrophilic segments in designed ...the ...
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Polyethylenimine-mediated gene delivery to the lung and therapeutic applications
... mediating delivery of plasmid DNA and ...for gene transfer ranges between 5 and 25 kDa, as assessed on L929 murine fi ...as gene delivery ...DNA delivery in COS-1 and Calu-3 cells ...
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Processing and characterisation of liposomes for use in gene delivery
... For gene therapy and DNA vaccination to become a reality the development of vectors capable of the delivery of the therapeutic gene to the required cells in an effective and safe manner is ...
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Biophysical studies of synthetic gene delivery systems
... viral gene delivery systems are regarded as attractive alternatives owing mainly to their safety, decreased immunogenicity, ability to package large-size DNA fragments, and relatively simple manufacturing ...
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Cationic lipids and investigations into non-viral gene delivery systems
... The interaction of cationic liposomes with negatively charged vesicles and biological membranes was investigated by Stamatatos et al}^ The fusion of liposomes, comprised of PE lipids and DOTAP, with negatively charged ...
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Noninvasive gene delivery to foveal cones for vision restoration
... driving gene expression in cones (4, 18, 19, 42, 43) and tested them for specificity and strength of cone transduction side by ...intravitreal delivery, only ...nonspecific gene expression in inner ...
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A sight on the current nanoparticle based gene delivery vectors
... acid delivery to ...therefore gene transfer efficiency), (3) a spacer between two mentioned sections that influences the determination of chemical stability, biodegradability and gene transfection ...
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ENCAPSULATION OF ? DNA IN CHITOSAN MICROSPHERES AS A GENE DELIVERY VEHICLE
... The results of this study suggest that a complex coacervation system is an excellent choice for sustained gene delivery and that it can potentially be utilized for delivery of multiple genes. In ...
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A promising gene delivery system developed from PEGylated MoS2 nanosheets for gene therapy
... (PEI). The amino end of positively charged nanomaterials can bind to the negatively charged small interfering RNA (siRNA). After detection of physical and chemical characteristics of the nanomaterial, cell toxicity was ...
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Multiple Immediate-Early Gene-Deficient Herpes Simplex Virus Vectors Allowing Efficient Gene Delivery to Neurons in Culture and Widespread Gene Delivery to the Central Nervous System In Vivo
... effective gene delivery both to neurons in culture and to the central nervous system in ...vivo. Gene delivery in vivo is further enhanced by the retrograde transport capabilities of ...by ...
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Electrospun nanofibers as versatile interfaces for efficient gene delivery
... of gene vectors incorporated in the core layers and can also extend the duration of gene delivery (Figure ...of gene vectors in the core layers to the outer ...dual gene vectors that ...
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Mannosylated liposomes for targeted gene delivery
... this study, a novel conjugated ligand, ie, mannose-PEG-PE (M-PEG-PE), was synthesized, and M-PEG-PE-modified Lipofectamine™ 2000 (Lipo) liposomes were investigated as an active targeting gene delivery ...
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Engineering biodegradable and multifunctional peptide-based polymers for gene delivery
... The delivery of therapeutic genes to the CNS can be bene- ficial for the treatment of neurological disorders ...However, gene delivery to the CNS using nonviral vectors has not been successful due to ...
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Biocleavable Polycationic Micelles as Highly Efficient Gene Delivery Vectors
... To evaluate the potential application of cationic micelles in gene delivery, the in vitro gene transfection experiments were conducted on human embryonic kidney (293T) cell line using pEGFP-C1 ...
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Cardiac adenoviral S100A1 gene delivery rescues failing myocardium
... mediated gene delivery to nonfailing cultured ventricular cardio- myocytes or engineered heart tissue rather than in the context of ...S100A1 gene delivery to an experimental rat HF ...S100A1 ...
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Gene delivery with organic electronic biomaterials
... and delivery, with metallic SWNTs delivering siRNA into the nucleus of keratinocytes, whereas semiconducting SWNTs transported siRNA only to the cytoplasm ...for gene delivery [68, 69], their ...
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