Gene-environment interactions
ARTICLE Gene-Gene and Gene-Environment Interactions Involving HLA-DRB1, PTPN22, and Smoking in Two Subsets of Rheumatoid Arthritis
... and gene-environment interactions are key features in the development of rheumatoid arthritis (RA) and other complex ...analyze interactions between smoking and the two ...multiplicative ...
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Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium
... investigated gene- environment interplay in relation to breast cancer ...of gene-environment interactions in relation to breast cancer could provide insight into the biological ...
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A novel approach to simulate gene environment interactions in complex diseases
... Background: Complex diseases are multifactorial traits caused by both genetic and environmental factors. They represent the major part of human diseases and include those with largest prevalence and mortality (cancer, ...
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Original Article Association of HLA-DMA rs1063478 polymorphism and gene-environment interactions with glioma
... the interactions between environmental and genetic ...(HLA-DMA) gene polymorphism and gene-environment interactions with the glioma ...glioma. Gene-environment ...
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Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies
... complex interactions between genetic polymorphisms and/or environmental factors, such as age, weight, and drug exposure can provide more accurate models for the prediction of complex pheno- types ...of ...
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Combinatory approaches prevent preterm birth profoundly exacerbated by gene environment interactions
... There are currently more than 15 million preterm births each year. We propose that gene-environment inter- action is a major contributor to preterm birth. To address this experimentally, we generated a ...
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Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease
... the environment might be even more pronounced in patients whose phenotypes are caused by the aggregation of small contributions from many genetic and non-genetic ...replicated gene-gene and ...
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Toward a 3D model of human brain development for studying gene/environment interactions
... This project is supported by the NCATS grant ‘A 3D Model of Human Brain Development for Studying Gene/Environment Interactions’ (1U18TR000547). Additional work by the group referred to in the article ...
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Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium.
... investigated gene- environment interplay in relation to breast cancer ...of gene-environment interactions in relation to breast cancer could provide insight into the biological ...
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Original Article Methylenetetrahydrofolate reductase gene A1298C polymorphism and gene-environment interactions are associated with carotid plaque in a south Chinese population
... (MTHFR) gene polymorphisms with the risk of carotid plaque in a south Chinese ...explore gene-environment interactions and potential relationship with carotid ...MTHFR gene ...
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A methodology to establish a database to study gene environment interactions for childhood asthma
... and gene-environment interactions can be studied, but cross-sectional and longitudinal stu- dies of asthmatic populations in Europe [18,35], United States[36] and Australia[2] have provided important ...
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Gene Environment Interactions in Asthma: Genetic and Epigenetic Effects
... candidate gene polymorphism studies, and genome-wide association studies ...a gene and the environment is a candidate interaction of both a well known gene and envi- ronmental factor in a ...
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Epigenetic understanding of gene-environment interactions in psychiatric disorders: a new concept of clinical genetics
... The transgenerational epigenetic inheritance of meta- stable epialleles was first demonstrated in a mouse strain, in which the methylation status of the Axin (Fu) allele, which is linked to the shape of the tail in the ...
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Assessing Gene-Environment Interactions for Common and Rare Variants with Binary Traits Using Gene-Trait Similarity Regression
... of gene–environment (G3E) interactions can facilitate our understanding of ge- netic heterogeneity under different environmental expo- sures (Kraft et ...G3E interactions is not an easy ...
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Power comparison of different methods to detect genetic effects and gene environment interactions
... Although this study argues in favor of the use of the case- only design to detect a G × E interaction, it shows that if one is interested in detecting gene effect, accounting for the exposure is not necessary. Of ...
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Non Random Distribution of Human Orofacial Clefts in Ghana: Gene Environment Interactions
... A questionnaire was administered to case families. After identification of case fami- lies, any congenital abnormalities, apart from clefts, if they occurred, were noted. All generations of each case pedigree was ...
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Gene × gene and gene × environment interactions for complex disorders
... p-values (after correction for the increased number of tests), and by the structure of the resultant multivariate model. We do not currently have a formal test for interac- tions. In part, this is because the main goal ...
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From 'omics' to complex disease: a systems biology approach to gene-environment interactions in cancer
... a gene, receptor or signaling pathway to a specific substance, what we are observing is how that molecule behaves when exposed to that specific sub- stance in that particular context ...rodent gene is very ...
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Parallel Genetic Changes and Nonparallel Gene–Environment Interactions Characterize the Evolution of Drug Resistance in Yeast
... any environment where large-effect loss-of-function mu- tations are available, many different nonsynonymous SNPs or indels could be selected, and we might expect these mu- tations to skew the distribution of ...
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Study design: Evaluating gene–environment interactions in the etiology of breast cancer – the WECARE study
... a gene, or genes, such as BRCA1 and/or BRCA2, and an environ- mental exposure, such as radiation, will constitute an important scientific and practical finding that will help to elucidate the mechanism through ...
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