Gene expression and candidate genes
Gene expression variation in Down's syndrome mice allows prioritization of candidate genes
... trisomic genes are over-expressed by a factor of 1.5, speculations on candidate genes were initially based on the molecular function of the ...lated gene products that exert trans effects, ...
14
Orthologous gene expression profiling in multi species models: search for candidate genes
... normalizing gene-expression values across spe- cies, we next identified orthologous genes with statistically significant changes in response to ...in gene-expression level was ...
13
Microarray study of gene expression profile to identify new candidate genes involved in the molecular mechanism of leptin-induced knee joint osteoarthritis in rat
... IGFBP6) was significantly up-regulated by leptin induc- tion. This suggests that leptin indeed played important roles in the pathogenesis of OA by adjusting these protein levels, which is consistent with previous ...
9
Investigation of candidate genes for osteoarthritis based on gene expression profiles
... of gene expression pro fi les is now providing new opportunities to uncover potential disease-related genes of SM associated with progression of ...the gene expression pro fi les of SM ...
5
Identification of potential candidate genes for hypertensive nephropathy based on gene expression profile
... REN expression in HTN [11]. Using a mRNA expression profil- ing dataset GSE37460, Berthier et ...more genes and pathways associated with HTN have not been ...
8
Candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profile
... mRNA expression profile used in this study was extracted from blood leukocytes, and another important cells in ARDS, such as epithelial and endothelial cells of the lung had not been ...
9
Candidate pathways and genes for prostate cancer: a meta-analysis of gene expression data
... and expression patterns [72]. The gene expres- sion data used in this analysis provide an integrative measure of gene expression; a more detailed assessment of gene expression is ...
11
Ranking candidate disease genes from gene expression and protein interaction: A katz-centrality based approach
... disease genes is important to understand the mechanistic and evolutionary aspects of pathogenesis, improve diagnosis and treatment of the disease, and aid in drug ...disease gene from hundreds of candidates ...
9
Evaluating gene × gene and gene × smoking interaction in rheumatoid arthritis using candidate genes in GAW15
... 15: Gene Expression Analysis and Approaches to Detecting Multiple Functional Loci Heather J Cordell, Mariza de Andrade, Marie-Claude Babron, Christopher W Bartlett, Joseph Beyene, Heike ...
5
An Expression QTL of Closely Linked Candidate Genes Affects pH of Meat in Chickens
... Targeted region and more hypotheses Characterization of genetic architecture of complex traits is very challenging, and so far it has been done for a few QTL of major effect and more specifically in model animals. Little ...
14
Expression analysis of asthma candidate genes during human and murine lung development
... analysed expression patterns from early gestational to postnatal stages of lung development in three different murine ...human gene expression pattern in the later stages of the developing ...
10
Amplified and Homozygously Deleted Genes in Glioblastoma: Impact on Gene Expression Levels
... and gene expression levels Out of 12,445 genes present in common in both the SNP and GEP arrays (including 259/305 amplified or homozygously deleted genes), 46 genes showed a high ...
11
Evaluation of Reference Genes for Differential Gene Expression Study of Bovine Tuberculosis
... reference gene, across the infection status (bTB positive or negative) and across experimental conditions (4 hours or overnight antigen stimulation), and is thus the reference gene of choice for use under ...
8
Characterization of IQ Domain Gene Homologs as Common Candidate Genes for Elongated Fruit Shape in Cucurbits
... highest expression of ClSUN8 occurred at -4 days after fertilization and gradually decreased; however, there was no direct relationship between the gene expression level and fruit ...
13
Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks
... global expression of genes and SNPs affecting the level of gene ...analysed genes, all SNPs localized in the region of the eQTL were taken from the ...the expression of the analysed ...
17
Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks
... global expression of genes and SNPs affecting the level of gene ...analysed genes, all SNPs localized in the region of the eQTL were taken from the ...the expression of the analysed ...
16
GeneTIER: prioritization of candidate disease genes using tissue-specific gene expression profiles.
... prioritize genes under the assumption that a disease gene will exist in a local net- work of genes which are highly differentially expressed between af- fected and unaffected ...differential ...
8
Identification of breast cancer candidate genes using gene co-expression and protein-protein interaction information
... BC candidate genes based on known BC related genes retrieved from BCGD (the Breast Cancer Gene Database, ...with gene co-expression and protein-protein interaction (PPI) data, we ...
9
Characterizing gene-gene interactions in a statistical epistasis network of twelve candidate genes for obesity
... the gene-gene interactions within the SEN. We identified three genes with significant heterophilicity (SH2B1, KCTD15 and TMEM18), and one gene with significant dyadicity ...Heterophilic ...
16
Expression analysis of candidate breast tumour suppressor genes on chromosome 16q
... GGCACGCT-3'; PFKP, 5'-ACCCCTTCGGCATTCGAC-3', 5'-AGCAAGGCGATGACTGCC-3'; TERF2IP, 5'-AAGCT- CAAGCGGAAGGCG-3', 5'-TCTGGAGTTCTCTTATTCT- GTGGTTC-3'; TAF1C, 5'-GACCGCACCGGAGTGAAG-3', 5'-AACGAAAAAGCAACAGACCACA-3'; and TERF2, ...
7