Gene fusions
The use of ultra-dense array CGH analysis for the discovery of micro-copy number alterations and gene fusions in the cancer genome
... eral gene fusions present in the MCF-7 cell line were Table 2 Genes involved in chromosomal rearrangements in MCF-7 cells, as identified by Hampton et ...
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Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples
... finding gene fusion ...finding gene fusions, rather than having a specific procedure for finding ...identifying gene fusions involves an initial step to identify candidate fusion ...
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Landscape of gene fusions in epithelial cancers: seq and ye shall find
... involving gene fusions in epithelial ...ALK gene fusion amplification, KIT amplification or increased auto-phosphorylation of EGFR ...family gene fusions described ...FGFR ...
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Gene Fusions derived by transcriptional readthrough are Driven by Segmental Duplication in Human
... Gene Fusions Derived by Transcriptional Readthrough Are Driven by Segmental Duplication in Human Epigenomic Marker Analysis Using 127-Epigenomes To determine whether the histone markers [r] ...
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GeneFuse: detection and visualization of target gene fusions from DNA sequencing data
... distinct gene-gene groups, and finally finds the breakpoints to locate gene ...discover gene fusions from BAM ...mapping-based gene fusion detectors have several ...
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NTRK gene fusions as novel targets of cancer therapy across multiple tumour types
... ed gene fusions involv- ing the NTRK gene enhanced the interest of the scien- ti fi c community in the development of drugs with inhibitory capacity for the TK domain of ...’ gene ...
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Use of Plasmid pVMG to Make Transcriptional ß-Glucuronidase Reporter Gene Fusions in the Rhizobium Genome for Monitoring the Expression of Rhizobial Genes In Vivo
... uidA gene in a pUC-based replicon, distinguishes pVMG as an effective vector to make chromosomal uidA transcriptional fusions in ...construction gene fusions of ...
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Evolution of gene fusions: horizontal transfer versus independent events
... of gene fusions was studied by phylogenetic analysis of the domains in the fused proteins and the orthologous domains that form stand-alone ...examined gene fusions that are represented in at ...
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Adenoid cystic carcinoma: emerging role of translocations and gene fusions
... MYB-NFIB fusions provide insight into the ACC pathogenesis and represent attractive diagnostic and therapeutic targets, their clinical significance is unclear, and a substantial subset of ACCs do not harbor the ...
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Interkingdom gene fusions
... interkingdom gene fusions (IKFs); that is, genes coding for proteins that apparently consist of domains originating from different primary ...a gene coding for the alien domain (or a larger protein ...
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Functional associations of proteins in entire genomes by means of exhaustive detection of gene fusions
... that gene fusion is widespread in evolution but forms a finite ...in gene fusion and that there is an upper limit for the predictive power of this approach obtainable from (currently available) 621 ...in ...
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Evolutionary Analyses of the Small Subunit of Glutamate Synthase: Gene Order Conservation, Gene Fusions, and Prokaryote-to- Eukaryote Lateral Gene Transfers
... dehydrogenase gene in ...a gene with greater similarities to prokaryotic genes encoding sulfide dehydrogenase than to any eukaryotic homologues, suggesting an LGT event from prokaryotes to an ancestor of ...
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FGFR3–TACC3 cancer gene fusions cause mitotic defects by removal of endogenous TACC3 from the mitotic spindle
... Figure 2. FT3 causes mitotic defects by reducing the level of endogenous TACC3 on the mitotic spindle. (a) Representative images of HeLa cells expressing GFP or FT3-GFP(649 – 838) and stained for TACC3 using an ...
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MYB-NFIB gene fusions identified in archival adenoid cystic carcinoma tissue employing NanoString analysis: an exploratory study
... A significant benefit of NanoString technology is the capability to produce highly sensitive and specific target molecule counts. In the context of ACC genomics, this level of gene expression quantification can ...
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Genetic and molecular analysis of vgU and vgW: two dominant vg alleles associated with gene fusions in Drosophila.
... nant. Both vg" and vgw cause severe dominant wing and haltere reductions, but are recessive or nearly so for erect postscutellar bristles and female sterility. T[r] ...
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Retrovirus promoter-trap vector to induce lacZ gene fusions in mammalian cells.
... Furthermore, by differential sorting of neomycin-resistant cell populations, clones were isolated in which lacZ expression was induced and repressed in growth-arrested and log phase cell[r] ...
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Evolutionary Origins of the Eukaryotic Shikimate Pathway: Gene Fusions, Horizontal Gene Transfer, and Endosymbiotic Replacements
... phylogenies of the arom domains, the relationship between the fungi and chromalveolates, within the arom clade, was weakly supported. However, in the three phylogenies with a mono- phyletic arom clade (Fig. 4A, 5, and ...
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An Epstein-Barr virus nuclear protein 2 domain essential for transformation is a direct transcriptional activator.
... To determine whether EBNA-2 has a direct transcriptional activating domain, gene fusions between the DNA-binding domain of GAL4 and EBNA-2 were tested in CHO and B-lymphoma cells for the[r] ...
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The neoepitope landscape in pediatric cancers
... exploring gene fusions, which are a major class of oncogenic drivers in pediatric ...and gene fusions using whole-genome sequencing ...
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Oncogenic HER2 fusions in gastric cancer
... HER3; and trastuzumab emtansine (T-DM1), which is tras- tuzumab conjugated with the antimitotic agent emtansine (DM1). The clinical application of these targeted agents dramatically changed the landscape of BC therapy ...
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